DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and fgd6

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:XP_017947731.2 Gene:fgd6 / 100379840 XenbaseID:XB-GENE-5824462 Length:1352 Species:Xenopus tropicalis


Alignment Length:597 Identity:136/597 - (22%)
Similarity:232/597 - (38%) Gaps:145/597 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 SNNSSPIGSPNPDAGKRLGFRRQA-----IQEIISSEKSYLEQLELL-MNF----------FVRP 99
            |::||.:...:|:..::....::.     .:||:||||.:::.|:|| ::|          |.:|
 Frog   771 SSDSSRVDLDHPEYKQKSRAAQKTKTYHIAKEIMSSEKVFVDALKLLHIDFRCAVAQAPRQFGKP 835

  Fly   100 LKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANM------ENVAHAFLKMAPFFKLYSVYAF 158
            :.|:.|:   |..|.:  :..::.||.:.|||||..|      :.:|..|:|..|:.|:||.|..
 Frog   836 VIEEKIL---NQILYY--LPQLYELNRDVLRELEERMSQWTEQQKIADIFVKKGPYLKMYSTYIR 895

  Fly   159 DYRGALFIIQDLISKNPVFRKFLEQTESRPE-VQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPA 222
            ::...:.::.|...|||.|...:...|..|. ....|...::.|:||:|:|:|||...|...|..
 Frog   896 EFDRNITLLDDQCKKNPGFAAVVRYFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLSED 960

  Fly   223 DADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKIT 287
            .:||...:.::..:...|:|.|..:::.:..|.||.:|.|| |....||:|.|..:|||.|.|::
 Frog   961 SSDYNDTQAALSVVIEVANHANDILKQGDNFQKLIQIQYSL-NGHHEIVQPGRVFLKEGTLMKLS 1024

  Fly   288 HKGTEIKRYCVLMSDIFMYCKMIKERAPNTVVENSL-ECCCIFPLKKCKV----YEMLPGNFKLT 347
            .|..: .|...|.:|..:|         .|.|::.: :...:..|...||    .|.......:.
 Frog  1025 RKVMQ-PRMFYLFNDALLY---------TTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELNIE 1079

  Fly   348 CQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTLR--KDSSKRTPIRKKDMKKFG------- 403
            ......|..:........|:..|..||:.:.:.:.|..  |...:..|..|:|. ..|       
 Frog  1080 SVERSFILSASSASERDDWLEAISLAIEEYAKKKITFNPTKSLEEADPGEKEDC-TLGSTAPIWI 1143

  Fly   404 ------------ADYVL------------------SPNKRKCEYDTVFRNKN---RSTDSEEETE 435
                        :::.|                  |.||...||     .||   |..|      
 Frog  1144 PDGRVTMCMICTSEFTLTWRRHHCRACGKIICQACSTNKHSLEY-----LKNHLARVCD------ 1197

  Fly   436 DSACFSRKRKVASGILRAPN-GNPMGKASSSSSSSVSMKRVAPPPPAPPPPPAVQMRHQPGRPGE 499
              .||...:|..|  |..|. |:|....|.|.:.|..:..:         |..   |.|...|..
 Frog  1198 --RCFQVLQKQES--LSTPKIGSPANHKSPSHALSTVLHSI---------PSG---RKQKKIPAA 1246

  Fly   500 LATASKENRISKLYKKIAAGDKVANVRGILKRSNVPAPNNDHDPSYGFASRYSDSKSYFRAHNVD 564
            |              |::|..:.:::.|.|:||.              ||:....:.:|...|  
 Frog  1247 L--------------KVSASTEDSSMSGYLQRSK--------------ASKKQWKQLWFVIKN-- 1281

  Fly   565 NTIPTFVKREDL 576
            ..:.|:...||:
 Frog  1282 KVLYTYAASEDI 1293

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 54/192 (28%)
PH-like 269..>311 CDD:302622 14/41 (34%)
PH 277..374 CDD:278594 19/101 (19%)
fgd6XP_017947731.2 RhoGEF 799..982 CDD:395496 54/187 (29%)
PH1_FGD6 1001..1123 CDD:275436 29/132 (22%)
FYVE_FGD6 1140..1200 CDD:277282 10/72 (14%)
PH2_FGD5_FGD6 1258..1346 CDD:270057 11/52 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm49235
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X316
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.000

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