Protein Alignment unc-13-4A and unc13d

DIOPT Version :10

• Sequence 1: NP_648096.4
• Gene: unc-13-4A / 38801
• FlyBaseID: FBgn0035756
• Length: 1371
• Species: Drosophila melanogaster
• Sequence 2: NP_001120507.1
• Gene: unc13d / 100145635
• XenbaseID: XB-GENE-1008072
• Length: 1105
• Species: Xenopus tropicalis
• Alignment Length: 1204
• Identity: 343/1204 - (28%)
• Similarity: 593/1204 - (49%)
• Gaps: 162/1204 - (13%)

  Fly   221 VDPRSNSGVQETDGSYFEN-------------FTSLGWKRE--NRRMSATRAAEARAEANPENER 270
            ::|..|.|    |....||             ||    :||  .|:....|..:.::...|:.|.
 Frog     1 MEPHENDG----DSPPSENKDLEMEPQPVRRGFT----RREAKYRKKGTVRTQQGQSVKEPDIES 57

  Fly   271 DPPAGEESIDRQDEKEKLYAEVLHTIANTVGAPAPGGQFAHYKDEMYLHAQRAFGVNPDRHYRLL 335
            .|      :.:..::..||.|.|:||.:.:|.|.|  :..:.::::|.:.|:||.::|..|..:|
 Frog    58 KP------LSQSAQRNLLYGEALYTIIHRMGMPEP--EHIYNEEQLYDYLQKAFNMDPGEHEAIL 114

  Fly   336 HASAEDKPKIIVLSAVVIEADGLEAKDANGFSDPYCMLGIQPDENGGPPVSPLPLPPTPRALSAD 400
            ......:..|..|...|.||.|:..||.:|||||||:|||....:|
 Frog   115 QRVRGLEAPIRCLKVTVKEAKGILGKDVSGFSDPYCLLGIDHRSSG------------------- 160

  Fly   401 MSGGFDNSATDSPPHRKHSFRLSFKRREAGRREQRDSLGGPVPAKLIKATSIKPHTLTPKWNEKF 465
                   .:.||.|.||              ::|:..:...:|...:..|.|...||.|.|||.|
 Frog   161 -------RSRDSSPDRK--------------QKQKAVVRNTIPEDRMHRTQIIGQTLNPVWNETF 204

  Fly   466 KFDIDDINTDTFHLDIWDHDDESCVMDAVSRLNEVRGVRGLGRFFKQVCQSARQGSQDDFLGSVN 530
            ..:|:|:...:|.:|:||.||...|.   ::|.::..:.||.|.||   ::.:...||||||:|.
 Frog   205 ILEIEDMEKASFQMDMWDSDDVETVR---TKLGDLTDLHGLKRIFK---EARKDKGQDDFLGNVV 263

  Fly   531 IPLSEIPSTGL----DAWFKLEARSHRSTVQGRIRLKLWLSTREDRNTVSEENHEQQIHKVEQLQ 591
            :.|     .||    |.|:.||.|:.....:||..|: :|.|.:.|.|:..:.....:|:  ||.
 Frog   264 LQL-----RGLKCKEDCWYNLEPRTETYPERGRCHLQ-FLLTHKKRGTMLTKTPSYIVHR--QLL 320

  Fly   592 RVFMQHEVTTHE-PSWTWCGDLPGPALTILHQLAVQSDLSDLHCAMARYVAAAKLNRSTPLDPKF 655
            :.|::||:|.|| .:.||.|::.....|||:..|.|.|||:.|..:|:::|.:||.:|.......
 Frog   321 QQFVRHEITRHEATNITWNGEISPHGATILYLHATQKDLSEFHQGLAQWLAYSKLYQSMEFSSSC 385

  Fly   656 LHRLLSDVEKQWNQPNQEALSRDLEQWLADAMNGFVERSLNQIRRHRDIFPALNPPSLIRLEFLL 720
            |...::.:|..|.|..   |..:.:..||::....:...::.::|:|.:||...|.|:.||:.||
 Frog   386 LLHHITSIEYLWVQGR---LQDEQKAELAESFESLLVYGVSLLQRYRIVFPLSAPRSVERLQSLL 447

  Fly   721 RCLGLLGSMRAFRAVCPFNKGVRGEVVNALRKGSVMWG-------QTVMRESQSMPNPLSNFVTT 778
            |.|..:...:|||.:|.....::..|..|::.|:..|.       |.:::..:.....|...|:.
 Frog   448 RVLIQMCKTKAFRELCSLTPDLQERVTEAIKAGTHEWFDLKRQHLQPMIQNQEENLKSLVRLVSD 512

  Fly   779 LTADIQLGQTYYHALFDNTNGIQYFSIIYKQYDAMVGEEVYSRMAAGQVPGVRMNLSQY--AVLE 841
            :|:|:|.....::..|.||..:..||:.:::.:.:|.:.:.|     |:|.::::.|.:  .:|
 Frog   513 VTSDLQSCHKTWNKCFINTIKVDIFSLTFQELEELVSQHLLS-----QLPSLKLSSSPHLSEIL- 571

  Fly   842 GDAEPVDTKPFELFLALQEFCQLKRHLSAQPQPPEKPLALSNSHEWFIPTLERWMMVSKAKALQR 906
                      ::|:|.|:|..:|..|::..    |..|.||..|.||..:|..|:..:...|.:|
 Frog   572 ----------YQLYLTLRELHKLHVHMAKS----ENDLPLSGFHRWFAESLPSWLQRAYTTAQER 622

  Fly   907 IRAAIRMDAICEGERIVRYSSSSVDTASTLLNIKEFWKVLNWPDEDTAIMMESQLIDVVCSAAMH 971
            ::.|:::|.:.....:.::|:|:||.::....|.:.|:.|:|||.:.|.|:..:..:.:|..|:.
 Frog   623 VQRAVQIDQLVPLSELQKHSASTVDLSTCYSQIGKTWQQLDWPDPEEAFMIMVKFTEDMCRIALT 687

  Fly   972 YCDLIHTALAD-SGYYEQQGPFRCSDDMCVTVNNVEYVRRTLAEF--RSDEQPLEESADNL---- 1029
            ||.||.....: ||   .:.....:..:|:.|||:|.:|..:...  :.|.:.||:...::
 Frog   688 YCSLIKRRAEEISG---NKDAAEAASKLCLVVNNIEQLRLVVRSLPTKLDWESLEQKTSHVISTD 749

  Fly  1030 ---------LESSLTHMENRCERILSKLAPLMQMSLQKAMFHLAWSPDSLPANQAIVPLLEYLDC 1085
                     |..::..::.....::..||..:...:.|.::.||...|....|.:|:||:::|:.
 Frog   750 QFQHTLHDQLRGAIVCLDREIRGVVQSLAQKLDAGIAKHLYSLASVNDFKDPNDSIIPLMKFLEN 814

  Fly  1086 HLAALNSALLTKNFNRSLRFIWK---TVLGEMSRQMETGDETDKPTHFHKRLYEALQLLIDFFHA 1147
            .|..:|..|:.:|||..|..:|.   .|:..:|.|:...      :.:::||:.||:.|...|||
 Frog   815 ELQYMNQNLVQENFNCLLSLLWSHILIVISGLSTQVTPS------SRYYQRLHAALKNLELCFHA 873

  Fly  1148 EGQGLLLECLHTEDFWRIEQRLQFHKTDTDRLIDMFYMQRLREQLMAVMPSPYGSLAVRAYF--N 1210
            ||.||.||.|||.:|..::|.|....:...:||:.:|..::::| .......||::.|:|.:  :
 Frog   874 EGCGLPLEDLHTAEFIALDQELGLSSSSIQKLIEHYYQDKIQQQ-NECTSEKYGAVTVKASYRSS 937

  Fly  1211 HDSLCVEVLHARDVVPLDPNGFSDPFVVIELLPRRVFLHCMEQQTNVHKRTLNPVFDECFEFSVT 1275
            ...|.||:|:|.:::|||.||.|||||.:.|.|:.:|.....:.|.:.|..|||::||.|:|.|.
 Frog   938 EQKLRVEILNAVNLLPLDSNGSSDPFVQLTLEPKHLFPAVEPRSTQIKKNELNPLYDETFDFLVA 1002

  Fly  1276 LEQCLTEGAMICFTVMDHDVLTANDFGGEAYLALGNIPGVADYSTS----VDNFHGLKQIELPLM 1336
            .|||...||.:..||.|:|.|.:|||.|||:|||.::||:.:..|.    |.|   :.|..|||:
 Frog  1003 AEQCKGAGACLLLTVFDYDTLRSNDFEGEAFLALSSLPGLQEKKTEEGGLVAN---IPQTRLPLI 1064

  Fly  1337 EQKDKCNPILQILEVRVNDKQAQDFV--RKQKSR 1368
            ..|...:.||||||.|.:|::|..||  |:|::|
 Frog  1065 HPKPNGDRILQILESRRSDREAVAFVKLRRQRAR 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-13-4A	NP_648096.4	C2A_Munc13-like	319..547	CDD:176058	68/231 (29%)
		MUN	<838..1153	CDD:461870	83/333 (25%)
		C2B_Munc13-like	1199..1330	CDD:175976	56/136 (41%)
unc13d	NP_001120507.1	C2A_Munc13-like	98..279	CDD:176058	68/231 (29%)
		MUN	<642..878	CDD:461870	62/244 (25%)
		C2B_Munc13-like	924..1058	CDD:175976	56/136 (41%)