DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT19 and LamC

DIOPT Version :9

Sequence 1:NP_002267.2 Gene:KRT19 / 3880 HGNCID:6436 Length:400 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:375 Identity:110/375 - (29%)
Similarity:178/375 - (47%) Gaps:79/375 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    80 EKLTMQNLNDRLASYLDKVRALEAANGELEVK--------------IRDWYQKQGPGPSR----- 125
            ||..:|:||||||.|:|::|.||..|..|..:              ::..|:|:.....:     
  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDET 110

Human   126 ---------DYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDF-------------RTK 168
                     |....:....||:.::...|.|   ..:..:||||..:.:             |.|
  Fly   111 AKEKAKLEIDIKRLWEENDDLKPRLDKKTKE---ATVAENNARLYENRYNEVNGKYNQSLADRKK 172

Human   169 FETEQALRMSVEADINGLRRVLDEL-------TLARTDLEMQIEGLKEELAYLKKNHEEEISTLR 226
            || :||..:::|.:  .|||.||:|       ||||.|||.|.:.|:||||:..:.|.:|::..|
  Fly   173 FE-DQAKELALENE--RLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETR 234

Human   227 -------GQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEEL----NR 280
                   .::.|::|.:.::    .|.:.|.::|.|||.....||::.|..:.:..:.|    ||
  Fly   235 SRRQIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANR 295

Human   281 EVAGH---TEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALI 342
            ...|.   ||::::.|:::..|...||.|| :..:.|:.:....:.|.:||.:     .|.| .|
  Fly   296 AAQGSALATEEVRLMRTKIDGLNAKLQNLE-DTNAGLNARIRELENLLDTERQ-----RHNQ-YI 353

Human   343 SGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYN 392
            :.:||:|..:|.:...|.||||.|||||..|:.|||.|..||.|:|...|
  Fly   354 ASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLN 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT19NP_002267.2 Head 1..79
Filament 79..390 CDD:278467 109/371 (29%)
Coil 1A 80..115 16/48 (33%)
Linker 1 116..133 3/30 (10%)
Coil 1B 134..225 36/110 (33%)
Linker 12 226..248 4/28 (14%)
Necessary for interaction with PNN. /evidence=ECO:0000269|PubMed:10809736 244..390 51/152 (34%)
Coil 2 249..387 48/144 (33%)
Rod-like helical tail 388..400 2/5 (40%)
LamCNP_001260974.1 Filament 45..401 CDD:278467 109/371 (29%)
ATP-synt_B <67..>142 CDD:304375 11/77 (14%)
MreC <178..>224 CDD:302802 20/47 (43%)
LTD 473..574 CDD:279300
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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