DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED4 and med4

DIOPT Version :9

Sequence 1:	NP_648094.1	Gene:	MED4 / 38799	FlyBaseID:	FBgn0035754	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	XP_031751774.1	Gene:	med4 / 496653	XenbaseID:	XB-GENE-972352	Length:	267	Species:	Xenopus tropicalis

Alignment Length:	263	Identity:	114/263 - (43%)
Similarity:	157/263 - (59%)	Gaps:	39/263 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFHLSTKERLLLLIDDIEMIAKELIEQAHQKISST-ELVDLLDLLVAKDEEFRKMLELAEEQAK 64
            :|.||...|.       |||:|.    ..:||:|.. |...:|:||:.||.||::::::|..|.|
Frog    32 LSGHLKALEL-------IEMLAL----SRNQKLSQPGEENQILELLIQKDGEFQELMKVALSQGK 85

  Fly    65 VEEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAH 129
            :.:.|..|..:||..|.:||:|||.||:||.||:||::||::||.||::|.|..:||||||||||
Frog    86 IHQEMQVLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGAISSEELIKYAH 150

  Fly   130 RISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSA 194
            |||::|||.|||||..||.|||||||:|||:||||             |.|.:|:      :|..
Frog   151 RISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLG-------------QMSNLPT------NGVN 196

  Fly   195 GSGSGSG-AGGEVPNAFQNQFNWNLGELHMTM--GASGNTVALET-----RAQDDVEVMSTDSSS 251
            |...|.. |.|.:|:....|:.|...::.|.|  ....|...:|:     ..::|||||||||||
Frog   197 GHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSNEFLMESLGPNKENEEDVEVMSTDSSS 261

  Fly   252 SSS 254
            |||
Frog   262 SSS 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED4	NP_648094.1	Med4	47..189	CDD:287038	73/141 (52%)
med4	XP_031751774.1	Med4	61..>188	CDD:401849	74/139 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8568
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3691
OMA	1	1.010	-	-		QHG46272
OrthoDB	1	1.010	-	-		D1333917at2759
OrthoFinder	1	1.000	-	-		FOG0006646
OrthoInspector	1	1.000	-	-		otm48218
Panther	1	1.100	-	-	LDO	PTHR13208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2637
SonicParanoid	1	1.000	-	-		X4874
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110