DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED4 and MED4

DIOPT Version :9

Sequence 1:	NP_648094.1	Gene:	MED4 / 38799	FlyBaseID:	FBgn0035754	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	NP_054885.1	Gene:	MED4 / 29079	HGNCID:	17903	Length:	270	Species:	Homo sapiens

Alignment Length:	261	Identity:	113/261 - (43%)
Similarity:	165/261 - (63%)	Gaps:	30/261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 STKERLLLLIDDIEMIAKELIE----QAHQK-ISSTELVDLLDLLVAKDEEFRKMLELAEEQAKV 65
            ||:||||..::|:|::::||||    ..:|| :.:.|...:|:||:.:|.||:::::||..|.|:
Human    25 STRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKI 89

  Fly    66 EEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAHR 130
            ...|..|..:||..|.:||:|||.||:||.||:||::||::||.||.:|.|..:||||:||||||
Human    90 HHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHR 154

  Fly   131 ISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSAG 195
            ||::|||.|||||..||.|||||||:|||:||||:    :|..:....|..:|.:
Human   155 ISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQ----MNNPSTNGVNGHLPGD---------- 205

  Fly   196 SGSGSGAGGEVPNAFQNQFNWNLGELHMTMGASGNT--VALE-----TRAQDDVEVMSTDSSSSS 253
                :.|.|.:|:....|:.|...::.|.|....::  ..||     ...:||||:|||||||||
Human   206 ----ALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSS 266

  Fly   254 S 254
            |
Human   267 S 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED4	NP_648094.1	Med4	47..189	CDD:287038	72/141 (51%)
MED4	NP_054885.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Med4	64..>189	CDD:401849	70/124 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..270		16/50 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142479
Domainoid	1	1.000	150	1.000	Domainoid score	I4406
eggNOG	1	0.900	-	-		E1_KOG4552
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8568
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3885
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46272
OrthoDB	1	1.010	-	-		D1333917at2759
OrthoFinder	1	1.000	-	-		FOG0006646
OrthoInspector	1	1.000	-	-		oto89464
orthoMCL	1	0.900	-	-		OOG6_105627
Panther	1	1.100	-	-	LDO	PTHR13208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4874
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770