DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED4 and MMACHC

DIOPT Version :9

Sequence 1:	NP_648094.1	Gene:	MED4 / 38799	FlyBaseID:	FBgn0035754	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	NP_056321.2	Gene:	MMACHC / 25974	HGNCID:	24525	Length:	282	Species:	Homo sapiens

Alignment Length:	99	Identity:	20/99 - (20%)
Similarity:	39/99 - (39%)	Gaps:	22/99 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KELIEQAHQKISSTELVDLLDLLVAKDEEFRKMLELAEEQAKVEEAMDQLRAKV----EVHDREI 83
            |..::..|.::    |.|.:|..|            |....:|.|::.:|:.::    |||....
Human    64 KPFLQSCHLRM----LTDPVDQCV------------AYHLGRVRESLPELQIEIIADYEVHPNRR 112

  Fly    84 QKLQKSLKDAELILSTAIFQARQKLASINQANKR 117
            .|:  ..:.|..:...|.:..||.:.:....|:|
Human   113 PKI--LAQTAAHVAGAAYYYQRQDVEADPWGNQR 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED4	NP_648094.1	Med4	47..189	CDD:287038	14/75 (19%)
MMACHC	NP_056321.2	MMACHC	20..234	CDD:406971	20/99 (20%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:21697092, ECO:0000269\|PubMed:22642810, ECO:0007744\|PDB:3SC0, ECO:0007744\|PDB:3SOM	115..118		0/4 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:21697092, ECO:0000269\|PubMed:22642810, ECO:0007744\|PDB:3SC0, ECO:0007744\|PDB:3SOM	129..131		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4552
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900