Protein Alignment Cdc27 and CDC23

DIOPT Version :10

• Sequence 1: NP_648093.2
• Gene: Cdc27 / 38798
• FlyBaseID: FBgn0012058
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: NP_012036.1
• Gene: CDC23 / 856571
• SGDID: S000001209
• Length: 626
• Species: Saccharomyces cerevisiae
• Alignment Length: 391
• Identity: 99/391 - (25%)
• Similarity: 174/391 - (44%)
• Gaps: 87/391 - (22%)

  Fly   512 VLLNNSL-NNAQTMAHQLMGLKKQSADGLMAL---------LRGLAEAY--------QLLSNFQC 558
            :||||.| .|.|....:.:|.::.....:|..         |.|..|.|        |:..||
Yeast   266 LLLNNYLYQNFQFKFSENLGSQRTIEFNIMIKFFKLKVFEELNGQLEDYFEDLEFLLQVFPNF-- 328

  Fly   559 KAAIKQLETTIPKHHLNSSWVQSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWH 623
             ..:|....||..::|                 :|..|.:.|:.|.|.:|.||:.:|.||:.|:.
Yeast   329 -TFLKAYNATISYNNL-----------------DYVTAESRFDDIVKQDPYRLNDLETYSNILYV 375

  Fly   624 LQREVELSALAQDLINQDKTSPVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHE 688
            :|:..:|:.|||.:...|:..|.|.|:..|.:|.::|||.:|.:|:||:.:|.....::||:|||
Yeast   376 MQKNSKLAYLAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHE 440

  Fly   689 LVLTEEFDKAMDYFRAAVVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHI 753
            .|.......|::.:|.||...||.:.||:|:|..|:..:.:..:..::.||..:.|.:..|...:
Yeast   441 FVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVL 505

  Fly   754 G-----------AMQFYMKKKDLSLQTLNTAATLDPKNPLTRFHRGSIYFSLGKYQEALRELEEL 807
            |           |::.|.:       ::..:.|:|...        |||:.|.:..|.|.:|:|.
Yeast   506 GECYSKTGNKVEAIKCYKR-------SIKASQTVDQNT--------SIYYRLAQLYEELEDLQEC 555

  Fly   808 KE--------------VVPKESV---VFYLIGKIHKTLGNMDLALMHFSWATDLDPKGANNQIKD 855
            |:              :|..|:|   ::..|.:|  ..||..||   :.:|..:. .|.:.:|::
Yeast   556 KKFMMKCVDVEELLEGIVTDETVKARLWLAIFEI--KAGNYQLA---YDYAMGVS-SGTSQEIEE 614

  Fly   856 A 856
            |
Yeast   615 A 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc27	NP_648093.2	ANAPC3	16..94	CDD:463743
		BepA	38..168	CDD:443813
		TPR repeat	68..104	CDD:276809
		TPR repeat	109..143	CDD:276809
		Spy	540..>753	CDD:443119	64/229 (28%)
		TPR repeat	582..605	CDD:276809	4/22 (18%)
		TPR	652..>809	CDD:440225	44/167 (26%)
		TPR repeat	678..708	CDD:276809	10/29 (34%)
		TPR repeat	713..741	CDD:276809	7/27 (26%)
		TPR repeat	747..773	CDD:276809	4/36 (11%)
		TPR	776..>850	CDD:440225	21/90 (23%)
		TPR repeat	781..809	CDD:276809	8/27 (30%)
		TPR repeat	815..838	CDD:276809	7/25 (28%)
CDC23	NP_012036.1	ANAPC8	12..144	CDD:427675
		BepA	306..427	CDD:443813	41/140 (29%)
		TPR	391..>554	CDD:440225	47/177 (27%)
		TPR repeat	397..425	CDD:276809	12/27 (44%)
		TPR repeat	433..459	CDD:276809	9/25 (36%)
		TPR repeat	464..494	CDD:276809	7/29 (24%)
		TPR repeat	499..527	CDD:276809	4/34 (12%)
		TPR repeat	536..564	CDD:276809	9/35 (26%)