DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdc27 and cdc27

DIOPT Version :10

Sequence 1:NP_648093.2 Gene:Cdc27 / 38798 FlyBaseID:FBgn0012058 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_001072470.1 Gene:cdc27 / 779925 XenbaseID:XB-GENE-972658 Length:832 Species:Xenopus tropicalis


Alignment Length:925 Identity:368/925 - (39%)
Similarity:526/925 - (56%) Gaps:144/925 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MIQEPVQAAIWHCLNYYDFKDAVFLSERLCSEVESDETIFLLATSYFRSNQVHQAYWLLKEKARR 66
            ::|||||||||..||:|.::|||||:|||.:||.|:|.:|||||.|:||.:.::||.|||..:..
 Frog     3 VLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKAHSCA 67

  Fly    67 SPQCRFLQAKCAYELKKYAEAESALISTGFADAKNCDELQRDFGDLACFAYQLMAQICMRTERNK 131
            :|||::|.|||..:|.|.||.|..|........|:.:|:..:|||.|||...|:..:..:|:|..
 Frog    68 TPQCKYLLAKCCVDLSKLAEGEQILSGGVLNKQKSQEEIVTEFGDSACFTLSLLGHVYCKTDRLA 132

  Fly   132 LAVSALRRALKLNPFMWHAFADLCLLGQDTDAAAIFQIHSTDVF-----NTCQGSSVNANAMVLF 191
            ......:::|.||||:|..|..||.:|:..|....|::.|...|     |||. .:||.:::|  
 Frog   133 KGAECYQKSLSLNPFLWSPFESLCEIGEKPDPEQTFKLTSLQNFSNCLPNTCT-MTVNTHSVV-- 194

  Fly   192 GAEQQGQQHQERQSLITNLSNVSNYILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNNNNLNS 256
                   ||::..::          ::.||    |..|..|:....:|||..|:|:       :|
 Frog   195 -------QHRQPDTV----------LMETP----QDTIELNRLNLESSNMKYPLNS-------DS 231

  Fly   257 SISMLRGGLVQNSSMLAMLEDTPMGAPQDPAGQYQQNQQLYDMS-SGTPFRKQFKYLSAISPPTP 320
            |||.:..|::...|:       |:|.......:..||:.....| .|.|        :|:||.||
 Frog   232 SISYIDPGVISPDSL-------PLGTGTSILSKQAQNKPKTGRSLLGGP--------AALSPLTP 281

  Fly   321 SFGIMPLTSPCTGNDGSFIGNHTP-VMNI--SYSPMPQMLVEVNQEPKMMGKKLKTHVGGLINRK 382
            ||||:||.:|..| |||::..::. |:::  |.:|..:.:..::|    .|.|            
 Frog   282 SFGILPLETPSPG-DGSYLQTYSSCVLDVPSSGAPTKKSVARISQ----AGTK------------ 329

  Fly   383 EGSLNKPAVFTQAGN---ITP--------RTPNNNNVGNNGNMNVPPNPNAAVRRSSRLF-SNSY 435
                   :||:|:||   :||        ..|..:......:..:...|||..||||||| |:|.
 Frog   330 -------SVFSQSGNSRDVTPVLLVQTQGSGPQTSTTPQVLSPTIAAPPNALPRRSSRLFTSDSS 387

  Fly   436 SVKENNKSPNIANKFVQPRSPPRKAKSRMTKICLNNELIEDKSHHLSEKRKEKVETITSSGANNN 500
            :.|||:|  .:..|| .|:.|.||.||:                             ||.|....
 Frog   388 TTKENSK--KLKMKF-PPKMPNRKTKSK-----------------------------TSKGGVTQ 420

  Fly   501 SGGRSAAEEAKVLLNNSL---NNAQTMAHQLMGL--KKQSADGLMALLRGLAEAYQLLSNFQCKA 560
            :....:.|.:|  |::|:   ....::|.|:..|  :|.:|:|||:|||.:.:.|..|.::.||.
 Frog   421 ANMNDSLEISK--LDSSIISEGKISSVAPQIQALTIQKAAAEGLMSLLRDMGKGYVALCSYNCKE 483

  Fly   561 AIKQLETTIPKHHLNSSWVQSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQ 625
            ||..| :.:|.||.|:.||...||.|.:|:.||..|..:|..:.:.|..|::.|||||::|||||
 Frog   484 AINIL-SHLPSHHYNTGWVLCQIGRAYFELAEYLQAERVFSEVRRIESYRVEGMEIYSTTLWHLQ 547

  Fly   626 REVELSALAQDLINQDKTSPVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELV 690
            ::|.||.|::||.:.||.||..||.:|||||||:||:.|||||:||:||||.:.|::||||||.|
 Frog   548 KDVTLSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPGYAYAFTLLGHEFV 612

  Fly   691 LTEEFDKAMDYFRAAVVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHIGA 755
            ||||.|||:..||.|:..:|||||||||:|.||.||||:.|||:|:.|||.||||:||:|.|||.
 Frog   613 LTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGV 677

  Fly   756 MQFYMKKKDLSLQTLNTAATLDPKNPLTRFHRGSIYFSLGKYQEALRELEELKEVVPKESVVFYL 820
            :|..:||.|.:|.|||.|.::||||||.:|||.||.|:..||:.||:||||||::|||||:|::|
 Frog   678 VQHALKKSDKALDTLNKAISIDPKNPLCKFHRASILFANEKYKLALQELEELKQIVPKESLVYFL 742

  Fly   821 IGKIHKTLGNMDLALMHFSWATDLDPKGANNQIKDAFDSMAHP-------------SCCPANTTA 872
            |||::|.||...||||:||||.||||||||||||:|.|....|             .|.|..:.|
 Frog   743 IGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEAVTQEEQISECYPYESVA 807

  Fly   873 LDVDLEPTSERSDDS 887
            .|...|.:...:||:
 Frog   808 TDESQESSMTDADDT 822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdc27NP_648093.2 ANAPC3 16..94 CDD:463743 40/77 (52%)
BepA 38..168 CDD:443813 49/129 (38%)
TPR repeat 68..104 CDD:276809 14/35 (40%)
TPR repeat 109..143 CDD:276809 10/33 (30%)
Spy 540..>753 CDD:443119 117/212 (55%)
TPR repeat 582..605 CDD:276809 8/22 (36%)
TPR 652..>809 CDD:440225 101/156 (65%)
TPR repeat 678..708 CDD:276809 18/29 (62%)
TPR repeat 713..741 CDD:276809 19/27 (70%)
TPR repeat 747..773 CDD:276809 14/25 (56%)
TPR 776..>850 CDD:440225 49/73 (67%)
TPR repeat 781..809 CDD:276809 17/27 (63%)
TPR repeat 815..838 CDD:276809 13/22 (59%)
cdc27NP_001072470.1 ANAPC3 17..92 CDD:463743 39/74 (53%)
Spy 446..>671 CDD:443119 122/225 (54%)
TPR repeat 501..527 CDD:276809 9/25 (36%)
TPR 561..>731 CDD:440225 107/169 (63%)
TPR repeat 567..595 CDD:276809 19/27 (70%)
TPR repeat 600..630 CDD:276809 18/29 (62%)
TPR repeat 635..663 CDD:276809 19/27 (70%)
TPR repeat 669..697 CDD:276809 15/27 (56%)
NrfG 687..799 CDD:443378 63/111 (57%)
TPR repeat 703..731 CDD:276809 17/27 (63%)
TPR repeat 737..765 CDD:276809 17/27 (63%)

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