DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc27 and Cdc27

DIOPT Version :9

Sequence 1:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_006247595.2	Gene:	Cdc27 / 360643	RGDID:	1304921	Length:	827	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	363/915 - (39%)
Similarity:	509/915 - (55%)	Gaps:	131/915 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VQAAIWHCLNYYDFKDAVFLSERLCSEVESDETIFLLATSYFRSNQVHQAYWLLKEKARRSPQCR 71
            :|||||..||:|.::|||||:|||.:||.|:|.:|||||.|:||.:.::||.|||..:..:|||:
  Rat    10 LQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCK 74

  Fly    72 FLQAKCAYELKKYAEAESALISTGFADAKNCDELQRDFGDLACFAYQLMAQICMRTERNKLAVSA 136
            :|.|||..:|.|.||.|..|....|...|:.|:|..:|||.|||...|:..:..:|:|.......
  Rat    75 YLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSEC 139

  Fly   137 LRRALKLNPFMWHAFADLCLLGQDTDAAAIFQIHSTDVFNTCQGSSVNANAMVLFGAEQQGQQHQ 201
            .:::|.||||:|..|..||.:|:..|....|::.|...|::|..::  ..|:|    ......|:
  Rat   140 YQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNT--CTALV----SNHSLSHR 198

  Fly   202 ERQSLITNLSNVSNYILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNNNNLNSSISMLRGGLV 266
            :.::::|.          ||    |..|..|:....:|       |:..:.|.:||:|.:...::
  Rat   199 QPETVLTE----------TP----QDTIELNRLNLESS-------NSKYSLNTDSSVSYIDSAVI 242

  Fly   267 QNSSMLAMLEDTPMG-APQDPAGQYQQNQQLYDMSSGTPFRKQFKYLSAISPPTPSFGIMPLTSP 330
            ..       ::.|:| .|...:.|.|...:......|.|        :|:||.||||||:||.:|
  Rat   243 SP-------DNVPLGTGPSILSKQVQNKPKTGRSLLGGP--------TALSPLTPSFGILPLETP 292

  Fly   331 CTGNDGSFIGNHTPVMNISYSPMPQMLVEVNQEPKMMGKKLKTHVGGLINRKEGSLNKPAVFTQA 395
            ..| |||::.|:|...::  ..:|.......:....||     |.|.           .:||:|:
  Rat   293 SPG-DGSYLQNYTNTPSV--IDVPSTGAPTKKSVARMG-----HTGA-----------KSVFSQS 338

  Fly   396 GNITPRTP----NNNNVGNNGNM-------NVPPNPNAAVRRSSRLF-SNSYSVKENNKSPNIAN 448
            ||....||    ...:.|...:.       .:...|||..||||||| |:|.:.|||:|  .:..
  Rat   339 GNSREATPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSK--KLKM 401

  Fly   449 KFVQPRSPPRKAKSRMTKICLNNELIEDK-------SHHLSEKRKEKVETITSSGANNNSGGRSA 506
            || .|:.|.||.||:..|..:....|.|.       |..:||   .|:.|||..
  Rat   402 KF-PPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISE---GKISTITPQ----------- 451

  Fly   507 AEEAKVLLNNSLNNAQTMAHQLMGLKKQSADGLMALLRGLAEAYQLLSNFQCKAAIKQLETTIPK 571
                               .|...|:|.:|:|||:|||.:.:.|..|.::.||.||..| :.:|.
  Rat   452 -------------------IQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINIL-SHLPS 496

  Fly   572 HHLNSSWVQSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQREVELSALAQD 636
            ||.::.||...||.|.:|:.||..|..||..:.:.|..|::.|||||::|||||::|.||.|::|
  Rat   497 HHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKD 561

  Fly   637 LINQDKTSPVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELVLTEEFDKAMDY 701
            |.:.||.||..||.:|||||||:||:.|||||:||:||||::.|:|||||||.|||||.|||:..
  Rat   562 LTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALAC 626

  Fly   702 FRAAVVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHIGAMQFYMKKKDLS 766
            ||.|:..:|||||||||:|.||.||||:.|||:|:.|||.||||:||:|.|||.:|..:||.:.:
  Rat   627 FRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 691

  Fly   767 LQTLNTAATLDPKNPLTRFHRGSIYFSLGKYQEALRELEELKEVVPKESVVFYLIGKIHKTLGNM 831
            |.|||.|..:||||||.:|||.|:.|:..||:.||:||||||::|||||:|::||||::|.||..
  Rat   692 LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 756

  Fly   832 DLALMHFSWATDLDPKGANNQIKDAFDSMAHPSCCPANTTALDVDLEP-TSERSDDSTQAQQDGS 895
            .||||:||||.||||||||||||:|.|....|.           |.|| |.|.....|...|:.|
  Rat   757 HLALMNFSWAMDLDPKGANNQIKEAIDKRYLPD-----------DEEPITQEEQIMGTDESQESS 810

  Fly   896 Y-DSD 899
            . |:|
  Rat   811 MTDAD 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650	40/77 (52%)
		TPR_11	67..145	CDD:290150	28/77 (36%)
		TPR repeat	68..104	CDD:276809	15/35 (43%)
		TPR repeat	109..143	CDD:276809	10/33 (30%)
		TPR_12	539..601	CDD:290160	25/61 (41%)
		TPR repeat	582..605	CDD:276809	9/22 (41%)
		TPR	590..850	CDD:223533	157/259 (61%)
		TPR_1	645..678	CDD:278916	23/32 (72%)
		TPR repeat	678..708	CDD:276809	19/29 (66%)
		TPR_1	713..746	CDD:278916	23/32 (72%)
		TPR repeat	713..741	CDD:276809	19/27 (70%)
		TPR repeat	747..773	CDD:276809	13/25 (52%)
		TPR repeat	781..809	CDD:276809	16/27 (59%)
		TPR repeat	815..838	CDD:276809	13/22 (59%)
Cdc27	XP_006247595.2	ANAPC3	19..94	CDD:403946	39/74 (53%)
		TPR	504..765	CDD:223533	128/260 (49%)
		TPR repeat	504..530	CDD:276809	0/25 (0%)
		TPR repeat	570..598	CDD:276809	11/27 (41%)
		TPR repeat	603..633	CDD:276809	14/29 (48%)
		TPR repeat	638..666	CDD:276809	17/27 (63%)
		TPR repeat	672..699	CDD:276809	19/26 (73%)
		TPR repeat	706..734	CDD:276809	18/27 (67%)
		TPR repeat	740..768	CDD:276809	16/27 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340949
Domainoid	1	1.000	157	1.000	Domainoid score	I4075
eggNOG	1	0.900	-	-		E2759_KOG1126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H960
Inparanoid	1	1.050	589	1.000	Inparanoid score	I955
OMA	1	1.010	-	-		QHG57830
OrthoDB	1	1.010	-	-		D146255at33208
OrthoFinder	1	1.000	-	-		FOG0004432
OrthoInspector	1	1.000	-	-		oto98587
orthoMCL	1	0.900	-	-		OOG6_101939
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770