DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc27 and nuc2

DIOPT Version :9

Sequence 1:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_594604.2	Gene:	nuc2 / 2542438	PomBaseID:	SPAC17C9.01c	Length:	665	Species:	Schizosaccharomyces pombe

Alignment Length:	871	Identity:	218/871 - (25%)
Similarity:	360/871 - (41%)	Gaps:	241/871 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VQAAIWHCLNYYDFKDAVFLSERLCSEVESDETIFLLATSYFRSNQVHQAYWLLKEKARRSPQCR 71
            ::..||:|::..::.:::|.||||.:..:|:|:::|||.|:|.:...:..|.||.......| |.
pombe     5 LKCLIWYCIDNQNYDNSIFYSERLHAIEDSNESLYLLAYSHFLNLDYNIVYDLLDRVISHVP-CT 68

  Fly    72 FLQAKCAYELKKYAEAESAL---------ISTGFADAKNCDELQRDFGDLACFAYQLMAQICMRT 127
            :|.|:.:..|.:|.:..||:         |.....|:.:    .|...|.:|. ..::..:..:.
pombe    69 YLFARTSLILGRYKQGISAVEACRSNWRSIQPNINDSIS----SRGHPDASCM-LDVLGTMYKKA 128

  Fly   128 ERNKLAVSALRRALKLNPFMWHAFADLCLLGQDTDAAAIFQIHSTDVFNTCQG---SSVNANAMV 189
            ...|.|......|:.:||:.:.||.:|..:|...||..:|.|  .......:|   |..||.|.|
pombe   129 GFLKKATDCFVEAVSINPYNFSAFQNLTAIGVPLDANNVFVI--PPYLTAMKGFEKSQTNATASV 191

  Fly   190 LFGAEQQGQQHQERQSLITNLSNVSNYILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNNNNL 254
               .|....:..:..|..:|..:||..|.                                |:..
pombe   192 ---PEPSFLKKSKESSSSSNKFSVSESIA--------------------------------NSYS 221

  Fly   255 NSSISMLRGGLVQNSSMLAMLEDTPMGAPQDPAGQYQQNQQLYDMSSGTPFRKQFKYLSAISPPT 319
            |||||                                            .|.|.|..:.|
pombe   222 NSSIS--------------------------------------------AFTKWFDRVDA----- 237

  Fly   320 PSFGIMPLTSPCTGNDGSFIGNHTPVMNISYSPMPQMLVEVNQEPKMMGKKLKTHVGGLINRKEG 384
                                           |.:|....|.:|..|:.            ::.:.
pombe   238 -------------------------------SELPGSEKERHQSLKLQ------------SQSQT 259

  Fly   385 SLNKPAVFTQAGNITPRTPNNNNVGNNGNMNVPPNPNAAVRRSSRLFSNSYSVKENNKSPNIANK 449
            |.|..|                                        |:::.....||:..::.:.
pombe   260 SKNLLA----------------------------------------FNDAQKADSNNRDTSLKSH 284

  Fly   450 FVQPRSPPRKAKSRMTKICLNNELIEDKSHHLSEKRKEKVETITSSGANNNSGGRSAAEEAKVLL 514
            ||:||:...:..:|:|             :.|.|.|..|         ...|..:|..||.
pombe   285 FVEPRTQALRPGARLT-------------YKLREARSSK---------RGESTPQSFREED---- 323

  Fly   515 NNSLNNAQTMAHQLMGLKKQSADGLMALLRGLAEAYQLLSNFQCKAAIKQLETTIPKHHLNSSWV 579
                ||                  ||.||:...:...||:.::.:.|:...: ::|....|:.:|
pombe   324 ----NN------------------LMELLKLFGKGVYLLAQYKLREALNCFQ-SLPIEQQNTPFV 365

  Fly   580 QSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQREVELSALAQDLINQDKTS 644
            .:.:|:..:|:.:||.:..:|:.:....|.|:..||::|::|||||:.|.||.||.:.:..:..|
pombe   366 LAKLGITYFELVDYEKSEEVFQKLRDLSPSRVKDMEVFSTALWHLQKSVPLSYLAHETLETNPYS 430

  Fly   645 PVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELVLTEEFDKAMDYFRAAVVRD 709
            |.:||:..||||||:||..|:|...||:|:||.|.|:|||.|||....||::|:...||.|:..:
pombe   431 PESWCILANCFSLQREHSQALKCINRAIQLDPTFEYAYTLQGHEHSANEEYEKSKTSFRKAIRVN 495

  Fly   710 PRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHIGAMQFYMKKKDL--SLQTLNT 772
            .||||||||:|.:|.|..:.:.|:.|:.:|.:|||.|||::..||  ..|.:.||.  :|...:.
pombe   496 VRHYNAWYGLGMVYLKTGRNDQADFHFQRAAEINPNNSVLITCIG--MIYERCKDYKKALDFYDR 558

  Fly   773 AATLDPKNPLTRFHRGSIYFSLGKYQEALRELEELKEVVPKESVVFYLIGKIHKTLGNMDLALMH 837
            |..||.|:.|.||.:..:...|..:.:||.|||:||.:.|.|:.|.:|:|||.|.:...:|||.|
pombe   559 ACKLDEKSSLARFKKAKVLILLHDHDKALVELEQLKAIAPDEANVHFLLGKIFKQMRKKNLALKH 623

  Fly   838 FSWATDLDPKGANNQIKDAFDSMAHP 863
            |:.|.:||.| |.:.||::.:::..|
pombe   624 FTIAWNLDGK-ATHIIKESIENLDIP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650	24/86 (28%)
		TPR_11	67..145	CDD:290150	16/86 (19%)
		TPR repeat	68..104	CDD:276809	10/44 (23%)
		TPR repeat	109..143	CDD:276809	5/33 (15%)
		TPR_12	539..601	CDD:290160	14/61 (23%)
		TPR repeat	582..605	CDD:276809	5/22 (23%)
		TPR	590..850	CDD:223533	109/261 (42%)
		TPR_1	645..678	CDD:278916	18/32 (56%)
		TPR repeat	678..708	CDD:276809	14/29 (48%)
		TPR_1	713..746	CDD:278916	15/32 (47%)
		TPR repeat	713..741	CDD:276809	12/27 (44%)
		TPR repeat	747..773	CDD:276809	8/27 (30%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR repeat	815..838	CDD:276809	9/22 (41%)
nuc2	NP_594604.2	ANAPC3	14..91	CDD:289650	23/77 (30%)
		TPR repeat	332..357	CDD:276809	3/25 (12%)
		TPR repeat	363..425	CDD:276809	21/61 (34%)
		TPR	376..652	CDD:223533	113/276 (41%)
		TPR_1	431..464	CDD:278916	18/32 (56%)
		TPR repeat	431..459	CDD:276809	15/27 (56%)
		SNAP	438..>597	CDD:305195	70/160 (44%)
		TPR repeat	463..512	CDD:276937	24/48 (50%)
		TPR repeat	466..493	CDD:276809	13/26 (50%)
		TPR repeat	498..528	CDD:276809	13/29 (45%)
		TPR_1	499..532	CDD:278916	15/32 (47%)
		TPR repeat	515..562	CDD:276937	16/48 (33%)
		TPR repeat	533..561	CDD:276809	9/29 (31%)
		TPR repeat	566..597	CDD:276937	11/30 (37%)
		TPR repeat	567..592	CDD:276809	8/24 (33%)
		TPR repeat	601..627	CDD:276809	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I597
OMA	1	1.010	-	-		QHG57830
OrthoFinder	1	1.000	-	-		FOG0004432
OrthoInspector	1	1.000	-	-		oto102022
orthoMCL	1	0.900	-	-		OOG6_101939
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R70
SonicParanoid	1	1.000	-	-		X3140
TreeFam	1	0.960	-	-
	12	11.860