DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc27 and Cdc27

DIOPT Version :9

Sequence 1:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_006533113.1	Gene:	Cdc27 / 217232	MGIID:	102685	Length:	831	Species:	Mus musculus

Alignment Length:	925	Identity:	365/925 - (39%)
Similarity:	515/925 - (55%)	Gaps:	135/925 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MIQEPVQAAIWHCLNYYDFKDAVFLSERLCSEVESDETIFLLATSYFRSNQVHQAYWLLKEKARR 66
            ::|||||||||..||:|.::|||||:|||.:||.|:|.:|||||.|:||.:.::||.|||..:..
Mouse     3 VLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCT 67

  Fly    67 SPQCRFLQAKCAYELKKYAEAESALISTGFADAKNCDELQRDFGDLACFAYQLMAQICMRTERNK 131
            :|||::|.|||..:|.|.||.|..|....|...|:.|:|..:|||.|||...|:..:..:|:|..
Mouse    68 TPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLA 132

  Fly   132 LAVSALRRALKLNPFMWHAFADLCLLGQDTDAAAIFQIHSTDVFNTCQGSSVNANAMVLFGAEQQ 196
            ......:::|.||||:|..|..||.:|:..|....|::.|...|::|..::  ...:|    ...
Mouse   133 KGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNT--CTTLV----SNH 191

  Fly   197 GQQHQERQSLITNLSNVSNYILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNNNNLNSSISML 261
            ...|::.::::|.          ||    |..|..|:....:|       |:..:.|.:||:|.:
Mouse   192 SLSHRQPETVLTE----------TP----QDTIELNRLNLESS-------NSKYSLNTDSSVSYI 235

  Fly   262 RGGLVQNSSMLAMLEDTPMGAPQDPAGQYQQNQQLYDMS-SGTPFRKQFKYLSAISPPTPSFGIM 325
                   .|.:...::.|:|.......:..||:.....| .|.|        :|:||.||||||:
Mouse   236 -------DSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGP--------TALSPLTPSFGIL 285

  Fly   326 PLTSPCTGNDGSFIGNHTPVMNI-----SYSPMPQMLVEVNQEPKMMGKKLKTHVGGLINRKEGS 385
            ||.:|..| |||::.|:|...::     :.:|..:....:....:|                 |.
Mouse   286 PLETPSPG-DGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARM-----------------GQ 332

  Fly   386 LNKPAVFTQAGN---ITP--------RTPNNNNVGNNGNMNVPPNPNAAVRRSSRLF-SNSYSVK 438
            ....:||:|:||   :||        ..|..:......:..:...|||..||||||| |:|.:.|
Mouse   333 TGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTK 397

  Fly   439 ENNKSPNIANKFVQPRSPPRKAKSRMTKICLNNELIEDK-------SHHLSEKRKEKVETITSSG 496
            ||:|  .:..|| .|:.|.||.||:..|..|....|.|.       |..:||   .|:.|:|..
Mouse   398 ENSK--KLKMKF-PPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISE---GKITTVTPQ- 455

  Fly   497 ANNNSGGRSAAEEAKVLLNNSLNNAQTMAHQLMGLKKQSADGLMALLRGLAEAYQLLSNFQCKAA 561
                                         .|...|:|.:|:|||:|||.:.:.|..|.::.||.|
Mouse   456 -----------------------------IQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEA 491

  Fly   562 IKQLETTIPKHHLNSSWVQSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQR 626
            |..| :.:|.||.::.||...||.|.:|:.||..|..||..:.:.|..|::.|||||::|||||:
Mouse   492 INIL-SHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQK 555

  Fly   627 EVELSALAQDLINQDKTSPVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELVL 691
            :|.||.|::||.:.||.||..||.:|||||||:||:.|||||:||:||||::.|:|||||||.||
Mouse   556 DVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 620

  Fly   692 TEEFDKAMDYFRAAVVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHIGAM 756
            |||.|||:..||.|:..:|||||||||:|.||.||||:.|||:|:.|||.||||:||:|.|||.:
Mouse   621 TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVV 685

  Fly   757 QFYMKKKDLSLQTLNTAATLDPKNPLTRFHRGSIYFSLGKYQEALRELEELKEVVPKESVVFYLI 821
            |..:||.:.:|.|||.|..:||||||.:|||.|:.|:..||:.||:||||||::|||||:|::||
Mouse   686 QHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLI 750

  Fly   822 GKIHKTLGNMDLALMHFSWATDLDPKGANNQIKDAFDSMAHPSCCPANTTALDVDLEP-TSERSD 885
            ||::|.||...||||:||||.||||||||||||:|.|....|.           |.|| |.|...
Mouse   751 GKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPD-----------DEEPITQEEQI 804

  Fly   886 DSTQAQQDGSY-DSD 899
            ..|...|:.|. |:|
Mouse   805 MGTDESQESSMTDAD 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650	40/77 (52%)
		TPR_11	67..145	CDD:290150	28/77 (36%)
		TPR repeat	68..104	CDD:276809	15/35 (43%)
		TPR repeat	109..143	CDD:276809	10/33 (30%)
		TPR_12	539..601	CDD:290160	25/61 (41%)
		TPR repeat	582..605	CDD:276809	9/22 (41%)
		TPR	590..850	CDD:223533	157/259 (61%)
		TPR_1	645..678	CDD:278916	23/32 (72%)
		TPR repeat	678..708	CDD:276809	19/29 (66%)
		TPR_1	713..746	CDD:278916	23/32 (72%)
		TPR repeat	713..741	CDD:276809	19/27 (70%)
		TPR repeat	747..773	CDD:276809	13/25 (52%)
		TPR repeat	781..809	CDD:276809	16/27 (59%)
		TPR repeat	815..838	CDD:276809	13/22 (59%)
Cdc27	XP_006533113.1	ANAPC3	17..92	CDD:372369	39/74 (53%)
		TPR	508..769	CDD:223533	130/260 (50%)
		TPR repeat	508..534	CDD:276809	2/25 (8%)
		TPR repeat	574..602	CDD:276809	11/27 (41%)
		TPR repeat	607..637	CDD:276809	16/29 (55%)
		TPR repeat	642..670	CDD:276809	19/27 (70%)
		TPR repeat	676..703	CDD:276809	18/26 (69%)
		TPR repeat	710..738	CDD:276809	20/27 (74%)
		TPR repeat	744..772	CDD:276809	14/27 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837230
Domainoid	1	1.000	161	1.000	Domainoid score	I4024
eggNOG	1	0.900	-	-		E2759_KOG1126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H960
Inparanoid	1	1.050	593	1.000	Inparanoid score	I969
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57830
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004432
OrthoInspector	1	1.000	-	-		oto95093
orthoMCL	1	0.900	-	-		OOG6_101939
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R70
SonicParanoid	1	1.000	-	-		X3140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790