DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc27 and mat-1

DIOPT Version :9

Sequence 1:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001364721.1	Gene:	mat-1 / 172145	WormBaseID:	WBGene00003132	Length:	790	Species:	Caenorhabditis elegans

Alignment Length:	899	Identity:	226/899 - (25%)
Similarity:	384/899 - (42%)	Gaps:	212/899 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VQAAIWHCLNYYDFKDAVFLSERLCSEVE---SDETIFLLATSYFRSNQVHQAYWLLKEKARRSP 68
            ::..|...:..|.|.||:||:| |..|.:   :.|::.|.|...:|:|:..:.|.||........
Worm    29 IEDEIHEMMKCYAFDDAIFLAE-LHYETDKSNNSESLLLYADCLYRANKKEECYGLLSSVKLSGA 92

  Fly    69 QCRFLQAKCAYELKKYAEAESALISTGFADAKNCDE--LQRDFGD---LACFAYQLMAQICMRTE 128
            :..:|.|:.:|:|.|..:...||...        |:  :::|..:   :|..|..|.||:.....
Worm    93 RLFYLLARVSYDLNKIDDCRGALFEH--------DDGVIRKDILEEPRVASHANLLHAQMLCDES 149

  Fly   129 RNKLAVSALRRALKLNPFMWHAFADLCLLGQDTDAAAIFQIHSTDVFNTCQGSSVNANAMVLFGA 193
            ...||:.:.:::|..|..:|.|.......| ..|.|..|:.|
Worm   150 YMDLALESCQKSLDENILLWSAIITYLRFG-GHDLAHTFEKH----------------------- 190

  Fly   194 EQQGQQHQERQSLITNLSNVSNYILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNN----NNL 254
                  |::...|..: |..|:....||                :.|:..|.:::..:    :.|
Worm   191 ------HRKSNGLYLD-SPASSLKSETP----------------SPNVPGPSSSSAASTAEPSRL 232

  Fly   255 NSSISMLRGGLV--------QNSSMLAMLEDTPMGAPQDPAGQYQQNQQLYDMSSGTPFRKQFKY 311
            .||:.....|.:        ..:|.:...:.||...|
Worm   233 ESSVRRSTRGTIASANRETRNTTSNITPRQSTPGSTP---------------------------- 269

  Fly   312 LSAISPPTP--SFGIMPLTSPCTGNDGSFIGNHTPVMNISYSPMPQMLVEVNQEPKMMGKKLKTH 374
             |.|:|..|  |..|..:|:..|  :.|..|:.:.:..               ||:....: .||
Worm   270 -SRINPTAPRKSSRISEMTTRRT--ESSVTGSRSSLFT---------------EPERPHTR-ATH 315

  Fly   375 VGGLINRKEGSLNKPAVFTQAGNITPRTPNNNNVGNNGNMNVPPNPNAAVRRSSRLFSNSYSVKE 439
            ...  ||...:||.....:.|.|...|: ...:|....:.:...||   ||.|.|:...:.:
Worm   316 SSR--NRANAALNSDTENSNASNTRTRS-GIASVTRGSSSSQRTNP---VRTSIRIADAAAA--- 371

  Fly   440 NNKSPNIANKFVQPRSPPRKAKSRMTKICLNNELIEDKSHHLSEKRKEKVETITS---------S 495
                   |||         .||:                  ||::|:.:.:.:.|         |
Worm   372 -------ANK---------TAKT------------------LSQRRRNEKQPLVSRNSNLARSLS 402

  Fly   496 GANNN------SGGRSAAEEAKVL------LNNSLNNAQTMAHQLMGLKKQSADG--------LM 540
            |:.|:      :..|.:.:|...:      :.:||||.:.|         ...||        |.
Worm   403 GSTNSLQVASTASERPSEDEVSQINPPLPSVASSLNNDEPM---------DIVDGVYDPEYKKLF 458

  Fly   541 ALLRGLAEAYQLLSNFQCKAA---IKQLETTIPKHHLNSSWVQSLIGLARYEMREYEAAVAIFET 602
            .:.:.:|...:.:|.:..::|   ..:|:..|   .||:|.|:..:|.|.:|..||.....|.:.
Worm   459 DVYQHIALIEESISTYNWRSADALFAKLDRDI---ILNTSMVRLQLGRACFEQSEYRECRNILDD 520

  Fly   603 IHKTEPCRLDYMEIYSSSLWHLQREVELSALAQDLINQDKTSPVTWCVSGNCFSLQKEHETAIKF 667
            :||....::|..|:.|:|:||||....||||:|.|..:.:..|.:||.:|||||||::|..||:.
Worm   521 LHKRRKWKVDGTELLSTSMWHLQDTHALSALSQILTTESRERPQSWCAAGNCFSLQRQHTQAIEC 585

  Fly   668 FKRAVQVDPDFVYSYTLLGHELVLTEEFDKAMDYFRAAVVRDPRHYNAWYGIGTIYSKQEKYELA 732
            .:||:|:|..|.|:||||||||::.:|.|||...||:|::..||.|.||||:|.::.|:|:...|
Worm   586 MERAIQLDKRFAYAYTLLGHELIVQDELDKAAGSFRSALLLSPRDYRAWYGLGLVHLKKEQNLTA 650

  Fly   733 EIHYVKALKINPQNSVILVHIGAMQFYMKKKDLSLQTLNTAATLDPKNPLTRFHRGSIYFSLGKY 797
            ..:..||:.|||.|..:|..:..::....:.|.:|..::.|.||:|.:...||:|..:.|...:.
Worm   651 LTNIQKAVNINPTNRAMLCTLSQIEQQRGQIDTALVLIDRALTLNPLDVACRFNRSRLLFEANRN 715

  Fly   798 QEALRELEELKEVVPKESVVFYLIGKIHKTLGNMDLALMHFSWATDLDPKGANN 851
            :|.|.||::||...|.|:.:|:|:.::|:.:||..|||:::|||.:|||:|..|
Worm   716 EECLVELDKLKASSPDEAFIFHLLARVHRRMGNTHLALLNYSWAAELDPRGEQN 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650	24/80 (30%)
		TPR_11	67..145	CDD:290150	17/82 (21%)
		TPR repeat	68..104	CDD:276809	7/35 (20%)
		TPR repeat	109..143	CDD:276809	8/36 (22%)
		TPR_12	539..601	CDD:290160	16/64 (25%)
		TPR repeat	582..605	CDD:276809	6/22 (27%)
		TPR	590..850	CDD:223533	104/259 (40%)
		TPR_1	645..678	CDD:278916	17/32 (53%)
		TPR repeat	678..708	CDD:276809	17/29 (59%)
		TPR_1	713..746	CDD:278916	14/32 (44%)
		TPR repeat	713..741	CDD:276809	11/27 (41%)
		TPR repeat	747..773	CDD:276809	3/25 (12%)
		TPR repeat	781..809	CDD:276809	9/27 (33%)
		TPR repeat	815..838	CDD:276809	8/22 (36%)
mat-1	NP_001364721.1	ANAPC3	39..118	CDD:403946	24/79 (30%)
		TPR	<453..631	CDD:223533	68/180 (38%)
		TPR repeat	563..591	CDD:276809	15/27 (56%)
		PEP_TPR_lipo	574..>764	CDD:274350	75/189 (40%)
		TPR repeat	596..626	CDD:276809	17/29 (59%)
		TPR repeat	631..658	CDD:276809	10/26 (38%)
		TPR repeat	665..692	CDD:276809	3/26 (12%)
		TPR repeat	699..724	CDD:276809	8/24 (33%)
		TPR repeat	733..761	CDD:276809	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159413
Domainoid	1	1.000	56	1.000	Domainoid score	I7397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I1733
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57830
OrthoDB	1	1.010	-	-		D146255at33208
OrthoFinder	1	1.000	-	-		FOG0004432
OrthoInspector	1	1.000	-	-		oto20443
orthoMCL	1	0.900	-	-		OOG6_101939
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R70
SonicParanoid	1	1.000	-	-		X3140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940