DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neos and NUP116

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_013762.1	Gene:	NUP116 / 855066	SGDID:	S000004650	Length:	1113	Species:	Saccharomyces cerevisiae

Alignment Length:	292	Identity:	60/292 - (20%)
Similarity:	109/292 - (37%)	Gaps:	78/292 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EELANKAASAL---HKSTFKQNMLTVRNASIKSKAANAIAKRN-----SNQGGQVTVQGGLVMSA 118
            :|...||:..|   .|.:|| |::..|...|.|:..|..::.|     |....|.|:.|...|..
Yeast   837 DESILKASELLFNPDKRSFK-NLINNRKMLIASEEKNNGSQNNDMNFKSKSEEQETILGKPKMDE 900

  Fly   119 AAAA-AGQPLI----NDCE----------IIVQNRENT---KYAEYIEERLKNSSLRV---DVLF 162
            ...| .|:.::    ||.|          :..:|:||.   :..||.|:..|.....|   |..|
Yeast   901 KETANGGERMVLSSKNDGEDSATKHHSRNMDEENKENVADLQKQEYSEDDKKAVFADVAEKDASF 965

  Fly   163 PNEDVLLGKVLANISSRGCLYAVL-------VTPQHEEHNSITVNILYGVPAEHRNMPLEDAITL 220
            .||:..:...|..:||    |::|       :...|:.:..|.    :..|.:...:||.....:
Yeast   966 INENYYISPSLDTLSS----YSLLQLRKVPHLVVGHKSYGKIE----FLEPVDLAGIPLTSLGGV 1022

  Fly   221 ISTDFRLKKQRDAVVLPPSTSIHKGQRRHPQEMQGLLERL------------ADNHPLTASQYEV 273
            |.| |.          |.:..|:......|:..:|:..|.            :...|:....:::
Yeast  1023 IIT-FE----------PKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQL 1076

  Fly   274 ILKYLEGEREEQLKREVGEANALAKLKAPDPE 305
            :.:::     |:||:     |..:|.::.|.:
Yeast  1077 VKRHI-----ERLKK-----NPNSKFESYDAD 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	28/112 (25%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407	5/18 (28%)
NUP116	NP_013762.1	Med15	358..>604	CDD:312941
		Nucleoporin_FG2	568..>720	CDD:406391
		Nucleoporin2	970..1108	CDD:397975	25/158 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900