DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neos and NUP100

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_012855.1	Gene:	NUP100 / 853796	SGDID:	S000001551	Length:	959	Species:	Saccharomyces cerevisiae

Alignment Length:	341	Identity:	65/341 - (19%)
Similarity:	116/341 - (34%)	Gaps:	110/341 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDPGSAGYNITKDPALAKSRIFLGNLPVCTREELVSICQPYGKVLGSMVQKNYGFVQFETEELAN 66
            ||.||:..|...||..:    :|.     :.:.|....:.|.|.|.....||...:....:|
Yeast   676 SDRGSSTSNSITDPESS----YLN-----SNDLLFDPDRRYLKHLVIKNNKNLNVINHNDDE--- 728

  Fly    67 KAASALHKSTFKQNMLTVRNASIKSKAANAIA------KRNSNQ-------------------GG 106
              ||.:...||     |..:||...:|:::||      |.:|.|                   .|
Yeast   729 --ASKVKLVTF-----TTESASKDDQASSSIAASKLTEKAHSPQTDLKDDHDESTPDPQSKSPNG 786

  Fly   107 QVTVQGGLVMSAAAAAAGQPLINDCEIIVQNRENTKYAEYIEERLKNSSLRVDVLFPNEDVLLGK 171
            ..::               |:|          ||.|.:..:...|.|     ||.|...:..:..
Yeast   787 STSI---------------PMI----------ENEKISSKVPGLLSN-----DVTFFKNNYYISP 821

  Fly   172 VLANISSRGCLYAVLVTPQHEEHNSITV------NILYGVPAEHRNMPLEDAITLISTDFRLKKQ 230
            .:..:.::..:       :..:.|::.:      .:.:..|.:..|.||:   ||..
Yeast   822 SIETLGNKSLI-------ELRKINNLVIGHRNYGKVEFLEPVDLLNTPLD---TLCG-------- 868

  Fly   231 RDAVVL-PPSTSIHKGQRRHPQEMQGLLER----LADNHPLTASQYEVILKYLEGEREEQLKREV 290
             |.|.. |.|.||::.....|::.:|:..|    |....|:.    :...|.::......|||.:
Yeast   869 -DLVTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPID----KETRKPIKNITHPLLKRSI 928

  Fly   291 G--EANALAKLKAPDP 304
            .  :.|.:.|.::.||
Yeast   929 AKLKENPVYKFESYDP 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	27/154 (18%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407	11/57 (19%)
NUP100	NP_012855.1	Nucleoporin_FG2	54..>246	CDD:406391
		ser_rich_anae_1	<290..>566	CDD:411418
		Nucleoporin_FG	429..509	CDD:404514
		Nucleoporin2	814..955	CDD:397975	26/154 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900