DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neos and Nup98

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_112336.2	Gene:	Nup98 / 81738	RGDID:	71033	Length:	1816	Species:	Rattus norvegicus

Alignment Length:	186	Identity:	43/186 - (23%)
Similarity:	74/186 - (39%)	Gaps:	34/186 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 RNMPLEDAITLISTDFRLKKQRDAV--------VLP-PSTSIHKGQ----RRHPQEMQGLLERLA 261
            |...|::.:.|..|...||.:...|        ::| |..|:..|.    ::.|::   |||...
  Rat  1203 RQRKLDEDLQLYQTPLELKLKHSTVHVDELCPLIVPNPGVSVIHGYADWVKKSPRD---LLELPI 1264

  Fly   262 DNH-PLTASQYEVI---LKYLEGEREE------QLKREVGEANALAKLKAPDPEIELQKKILSIM 316
            ..| .||.:..|.:   ||.|:.:.:|      .|:|....:..|:...||..|.|:.   |:..
  Rat  1265 VKHWSLTWTLCEALWGHLKELDSQLDEPSEYIQTLERRRAFSRWLSHTAAPQIEEEVS---LTRR 1326

  Fly   317 NKPAVTDVTSELMYPTFEAVKEDRRLMELLADDRVLAALESVYNS-DLRQILAEYL 371
            :.|    :.:...|.|...:.|...|.:...|.|:...|..:..| .:|::|...|
  Rat  1327 DSP----IEAVFSYLTGSRISEACCLAQQSGDHRLALLLSQLVGSQSVRELLTMQL 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407
Nup98	NP_112336.2	FG repeats 1	1..156
		Nucleoporin_FG	25..149	CDD:290362
		NupH_GANP	26..336	CDD:293373
		GLEBS, interaction with RAE1. /evidence=ECO:0000250	157..213
		FG repeats 2	214..480
		Nucleoporin_FG	215..303	CDD:290362
		Nucleoporin_FG	261..392	CDD:290362
		Nucleoporin2	740..880	CDD:282016
		Nup96	1333..1624	CDD:288926	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900