DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neos and nup98

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_956979.2	Gene:	nup98 / 777756	ZFINID:	ZDB-GENE-040426-1180	Length:	1814	Species:	Danio rerio

Alignment Length:	242	Identity:	54/242 - (22%)
Similarity:	90/242 - (37%)	Gaps:	66/242 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 QVTVQGGLVMSAAA-----AAAGQPLINDCEIIVQNRENTKYAEY----------IEERLKNSSL 156
            |..|...|:...|:     :.||:|.|.   .::||:..:....:          |.::| |.||
Zfish  1020 QEHVSSKLIQDVASTKLLLSGAGRPSIG---ALLQNKFTSGGGLFSQLPEVPFSGISQKL-NKSL 1080

  Fly   157 RVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNI-LYGVPAEHRNMPLEDAITL 220
            ..:..:|:    ||.            :.|:.|...|....||.. ..|.|     :|||.:|||
Zfish  1081 ASEAAWPS----LGP------------SFLLPPPPPEPTLRTVGARRLGGP-----VPLEASITL 1124

  Fly   221 ----ISTDFRLKKQRDAVV--LPPSTSIHKGQR---RHPQEMQ-------GLLERLADNHPLTAS 269
                :..|..|.:.|...|  .|..|.:|.|.:   .||.:..       |.|.:.....|:|.|
Zfish  1125 GKGRLLMDAALFRGRSFRVGWGPNWTLVHSGDQLSVTHPVKEPAAENLGFGFLPKPTKTKPITES 1189

  Fly   270 QYEVILKYLEGEREEQLKR---------EVGEANALAKLKAPDPEIE 307
            .::|.::.:.|...:|...         |:|..::....:.|.|.|:
Zfish  1190 PFKVRVEQVVGLEPKQSSESLSLYLRPLEIGLKHSTINTEEPCPFIQ 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	11/56 (20%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407
nup98	NP_956979.2	Nucleoporin_FG	39..133	CDD:290362
		Nucleoporin_FG	217..357	CDD:290362
		Nucleoporin_FG	324..>400	CDD:290362
		Nucleoporin2	741..881	CDD:282016
		Nup96	1333..1626	CDD:288926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900