DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neos and Nup98-96

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	70/411 - (17%)
Similarity:	131/411 - (31%)	Gaps:	123/411 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDPGSAGYNITKDPALAKSRIFLGNLPVCTREEL---VSICQPYGKVLGSMVQKNYGFVQFETEE 63
            :.||:.....::|....:|.:...||....:..:   :....|:...|..:|.:. ....:....
  Fly   746 NSPGATNGRESQDNGRRESWLHPNNLEKVRQHNIQTGMDQGSPHNSTLNELVPRK-PLDTYRPSS 809

  Fly    64 LANKAASALHKSTFKQNMLTV-RNASIKSKAAN--AIAKRNSNQGGQVTVQGGLVMSAAAAAAGQ 125
            ....:.|.:.::.|:....|: |..:..|:.||  .::.|::........|..|.:.||||.|..
  Fly   810 TVRLSVSTIPENPFEDQSSTIARRETFTSQQANESVLSNRSNEAEDSAANQSRLAIEAAAAEAAD 874

  Fly   126 P--------------------------LINDCEIIVQN----RENTKYAE-YIEERLKNSSLRVD 159
            .                          |..|...:|.|    ||.  |.. :..:.:..:.|.:|
  Fly   875 DESHPTGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREG--YGNVFFGKEMDVAGLNLD 937

  Fly   160 --VLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYGVPAEHRNMPL-----EDA 217
              |.|.|:::                                 |:|  |.:....|:     .||
  Fly   938 EIVHFRNKEI---------------------------------IIY--PDDENKPPIGQGLNRDA 967

  Fly   218 ITLISTDFRLKKQRDAVVLPPSTSIHKGQRRHPQEMQGLLERLADNH--------PLTAS---QY 271
            ...:...:.|.|.:...:..|       ||....:.:|.|.|:.|.:        |.|.|   :.
  Fly   968 QVTLDQVWPLDKTKHEAIKDP-------QRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRV 1025

  Fly   272 EVILKYLEGEREEQLKREVGEANALAKLKAPDPEIELQKKILSIMNKPAVTDVTSELMYPTFEAV 336
            :...||..|:.:|                  :.|:....|...|....|.....:|.|  |..::
  Fly  1026 KHFSKYGLGDSDE------------------EDELPTDPKKAKIATLEAQQRANAEKM--TLNSL 1070

  Fly   337 KEDRRLMELLA---DDRVLAA 354
            ::.:::.|..|   |.:.|.|
  Fly  1071 RQAQKISEDAARNLDPKALVA 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	28/166 (17%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407	7/60 (12%)
Nup98-96	NP_001262885.1	Nucleoporin_FG	395..481	CDD:316182
		Nucleoporin2	888..1027	CDD:309287	30/182 (16%)
		Nup96	1484..1762	CDD:314912
		Nucleoporin_FG	<1..74	CDD:316182
		Nucleoporin_FG	50..164	CDD:316182
		Nucleoporin_FG	254..318	CDD:316182
		NupH_GANP	316..>522	CDD:318883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900