DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neos and Ncoa5

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001100013.1	Gene:	Ncoa5 / 296372	RGDID:	1307702	Length:	578	Species:	Rattus norvegicus

Alignment Length:	255	Identity:	79/255 - (30%)
Similarity:	126/255 - (49%)	Gaps:	60/255 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 AGQPLINDCEIIVQNRENTKYAEYIEERLKNSSLRVDVLFPNEDVLLGKVLANISSRGCLYAVLV 187
            |.:|:  ||.:||.|::...|||.:..::::..:.||::|.|.:|.|.:.|.::|..|..:|:::
  Rat   193 AERPV--DCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVI 255

  Fly   188 TPQHEEHNSITVNILYGVPAEHRNMPLEDAITLISTDF-RLK-----KQRDAVVLPPSTSIHK-- 244
            |.||:.|.|.||||::|.|.||||||..||:.|::.:: |.|     |:|:.:....:...:.
  Rat   256 TQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAI 320

  Fly   245 ------------GQRRHPQEMQGLLERLADNHPLTASQYEVILKYLEGEREEQLKRE-------- 289
                        |:..||..:|.|:..||||..|||.:.:.|:.||. ||:|:|.|.
  Rat   321 LQERDRGGPEEGGRGGHPPAIQSLINLLADNRYLTAEETDKIINYLR-ERKERLLRSSADSLPGP 384

  Fly   290 -----VGEANALAKLKA-----------------------PDPEIELQKKILSIMNKPAV 321
                 :|.|:. :.||.                       |..:.|||.||||:.|..||
  Rat   385 ISRQPLGAASG-SSLKTQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGAV 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	10/25 (40%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407
Ncoa5	NP_001100013.1	HisS	<185..255	CDD:223202	20/63 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421126at33208
OrthoFinder	1	1.000	-	-		FOG0006056
OrthoInspector	1	1.000	-	-		oto96243
orthoMCL	1	0.900	-	-		OOG6_109699
Panther	1	1.100	-	-	LDO	PTHR23295
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5759
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710