DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHD and LST7

DIOPT Version :9

Sequence 1:	NP_648090.1	Gene:	BHD / 38793	FlyBaseID:	FBgn0261111	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_011571.4	Gene:	LST7 / 852948	SGDID:	S000003289	Length:	242	Species:	Saccharomyces cerevisiae

Alignment Length:	241	Identity:	59/241 - (24%)
Similarity:	106/241 - (43%)	Gaps:	34/241 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NAVIALCHFCEAHGPCAIFCTQTL-RDTKLEDLSL-EQQTQKTCSACNYSMGKNNNAIYSRDTES 64
            :.||:|.|||:.|||..|..||:. :.|..|:|.: :..|:..|.:|.....:.:........|.
Yeast     3 STVISLAHFCDKHGPRIISVTQSAEKGTLGEELLVPDYPTESYCESCLLQFPEESTRSMRCFIED 67

  Fly    65 GATFVSTKVAVL--PEVASLVKQAAVLSLSNGTDASKDGEFVFFGDSSRGHILSHTFRVSDLQAR 127
             ..|::|:.:.:  ..:.|::|:|    .|..|....:..|:|| |..||..|...|::.|..||
Yeast    68 -VPFITTQYSSIRYQLLNSIIKRA----FSEETMIYDNMPFIFF-DDLRGLNLVIGFKLYDENAR 126

  Fly   128 GYSQLFSIIVLMKDKYFLLNIKPFLAEH--------------LKKVSSELQAAAKKTKETEEQTY 178
            |..:.:..|:.:..:....::| .|:||              :|.:.........||.|...:|.
Yeast   127 GNERRYCFILTVDSRSHDDSMK-MLSEHWNFIIGGFDKMIAYIKNIHKSEFLGKNKTVENNLETL 190

  Fly   179 SER-----QRRLSGAQFLMPTSRALLELTGEEHIFAQLHSHFSWLL 219
            :..     ..|.:.::|    .|.|:.||.::.:|.::|...|:||
Yeast   191 NNNAFIGSYLRANKSKF----GRNLVSLTDDKFLFVRIHKWNSFLL 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHD	NP_648090.1	Folliculin	67..221	CDD:288541	40/174 (23%)
BHD	NP_648090.1	Folliculin_C	275..459	CDD:293297
LST7	NP_011571.4	Folliculin	70..235	CDD:403032	40/173 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3715
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005615
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106566
Panther	1	1.100	-	-	LDO	PTHR31441
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740