Protein Alignment BHD and Flcn

DIOPT Version :10

• Sequence 1: NP_648090.1
• Gene: BHD / 38793
• FlyBaseID: FBgn0261111
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_955422.1
• Gene: Flcn / 303185
• RGDID: 735088
• Length: 579
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 153/565 - (27%)
• Similarity: 244/565 - (43%)
• Gaps: 114/565 - (20%)

  Fly     1 MNAVIALCHFCEAHGPCAIFCTQTLR----------DT--KLEDLSLEQ---------------- 37
            |||::|||||||.|||..:|||:.|.          |:  ::|....|:
  Rat     1 MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAE 65

  Fly    38 -----------QTQKTCSACNYSMGKNNNAIYSRDTESGATFVSTKVAVLPEVASLVKQAAVLSL 91
                       :....|..|. |:...:....|.|.|:...:||.:....|::.|:|:||.|.||
  Rat    66 GASTDSSSPGPKKSDMCEGCR-SLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRSL 129

  Fly    92 SNGTDASKDGEFVFFGDSSRGHILSHTFRVSDLQARGYSQLFSIIVLMKDKYFLLNIKPFLAEHL 156
            |......::|. :||||...|.:.||||.:.|..|||:.:.:|||.:|.|:.:|:|..|||...:
  Rat   130 SCEVCPGREGP-IFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGKI 193

  Fly   157 KKVSSELQAAAKKTKETEEQTYSERQRRLSGA--QFLMP----TSRALLELTGEEHIFAQLHSHF 215
            :.:.||||..|.|..|.|:....:|.:|::.|  .||..    .:|:|..||.:::::|.||:.|
  Rat   194 RGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSF 258

  Fly   216 SWLLLA-GSRFLTEHVTFG--------------------------------NLPWLPPQSSGRPP 247
            :|||.| ||| |||.:..|                                ..|.....:.||..
  Rat   259 AWLLKACGSR-LTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGREL 322

  Fly   248 AQRLTYNSSTLPMIESIDDPDLEEFFSLRHLKSVVRKEEFATVCYCALTGVKIVVRG-DPRKTFR 311
            |...| .||.|....|...|.|..|.||||::.|:....|..:.:..|.|.:::.:. |......
  Rat   323 ASCPT-ESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHS 386

  Fly   312 FMVCLKKLLPEPMHNLMRIDAQHQHSISSEYKIISVSNDIAVP---MASSSVYRIDFL------- 366
            ....|:.:||.....::...:|::.:....:  :.:|..:.:|   :||..|..::..
  Rat   387 AFEVLRTMLPVGCVRIIPYSSQYEEAYRCNF--LGLSPPVPIPAHVLASEFVVVVEVHTATRSNP 449

  Fly   367 -------DKHVNGHE--VSVKWPGELPRKLPDLMVKLLKAVEEKNFTELVLNKQTKVLIEEWKNK 422
                   |:.::.:|  |:...|....|..|.::.|:..|:..:|.:..|:::....|.|||.||
  Rat   450 HPAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWMNK 514

  Fly   423 VTCLNHAKSTSVQG-------KLKKVLGVQPHDQ-PIINYWSTHL 459
            |..|  .|.|.|..       ||..|||....|. .::.:|.|.|
  Rat   515 VKVL--FKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGL 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BHD	NP_648090.1	Folliculin	68..222	CDD:463323	60/160 (38%)
		Folliculin_C	270..459	CDD:465236	48/216 (22%)
Flcn	NP_955422.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..82		3/49 (6%)
		Folliculin	106..265	CDD:463323	59/159 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..320		1/25 (4%)
		Folliculin_C	345..566	CDD:465236	49/217 (23%)