DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BHD and bhd1

DIOPT Version :9

Sequence 1:	NP_648090.1	Gene:	BHD / 38793	FlyBaseID:	FBgn0261111	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_595962.1	Gene:	bhd1 / 2540297	PomBaseID:	SPBC24C6.08c	Length:	367	Species:	Schizosaccharomyces pombe

Alignment Length:	364	Identity:	70/364 - (19%)
Similarity:	115/364 - (31%)	Gaps:	150/364 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNAVIALCHFCEAHGPCAIFCTQTL----------RDTKLEDLSLEQQTQKTCSACNYSMGKNNN 55
            |:.|.||.|||||.||..|||||.|          ..|....:.:.:....:..|....:...||
pombe     1 MDVVFALGHFCEAEGPSIIFCTQKLHRSTVSKFFEHPTSKRSIGVTENGNDSPEAFKNELDNRNN 65

  Fly    56 A-----------IYSRDTESGATFVSTKVAVLPE--------------------VASLVKQAAVL 89
            |           ::..|:|.   ::..||:..||                    .:|.|..:.||
pombe    66 ADSQSLQSSTESLFKADSED---YLCKKVSKGPESPRVNSFHNSYSRNQSPISRKSSCVTCSTVL 127

  Fly    90 -----------------------------------------------------SLSNGTDASKDG 101
                                                                 :||..:|:..:.
pombe   128 PLEFSVPDVQPRLYTNSSTNPDVLYMSSQHPHTQQRYSTLKRLMVRCLSCEYSTLSEASDSMSNP 192

  Fly   102 EFVFFGDSSRGHILSHTFRVSDLQARGYSQLFSIIVLMKDKYFLLNIKPFLAEHLKKVSSELQAA 166
              :||||...|:::|.:|.:.|..|||..:.::||....::..|:....|::|....:...|:.:
pombe   193 --LFFGDQDNGYVISQSFSLRDPSARGGLRRYAIIATCPNQLDLILRYSFISEKFLHIVQFLRIS 255

  Fly   167 AKKTKETEEQTYSERQRRLSGAQFLMPT------------------------------------- 194
            :..||.....:.|:.....|...|..|:
pombe   256 SFNTKNDYSSSRSKTTASSSNGTFASPSFNISSLSGSSNIGTAPSYEISSSIGANVSSLAHTQRL 320

  Fly   195 --------------SRALLELTGEEHIFAQLHSHFSWLL 219
                          .|:|:::|..:.||..|||.|||:|
pombe   321 PSFSFLRRRDDIGEGRSLVDITCWDGIFVGLHSSFSWIL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHD	NP_648090.1	Folliculin	67..221	CDD:288541	46/277 (17%)
BHD	NP_648090.1	Folliculin_C	275..459	CDD:293297
bhd1	NP_595962.1	Folliculin	152..359	CDD:288541	37/208 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	43	1.000	Domainoid score	I3653
eggNOG	1	0.900	-	-		E1_KOG3715
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005615
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106566
Panther	1	1.100	-	-	LDO	PTHR31441
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R140
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840