DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BHD and FLCN

DIOPT Version :9

Sequence 1:	NP_648090.1	Gene:	BHD / 38793	FlyBaseID:	FBgn0261111	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001340158.1	Gene:	FLCN / 201163	HGNCID:	27310	Length:	597	Species:	Homo sapiens

Alignment Length:	593	Identity:	154/593 - (25%)
Similarity:	243/593 - (40%)	Gaps:	152/593 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNAVIALCHFCEAHGPCAIFCTQTLR----------------------------------DTKLE 31
            |||::|||||||.|||..:|||:.|.                                  .:..|
Human     1 MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGDGNEDSPGQGEQAEEEEGGIQMNSRMRAHSPAE 65

  Fly    32 DLSLEQQT-----QKTCSACNYSMGKNNNAIYSRDTESGATFVSTKVAVLPEVASLVKQAAVLSL 91
            ..|:|..:     ...|..|. |:...:....|.|.|:...:||.:....|::.|:|:||.|.||
Human    66 GASVESSSPGPKKSDMCEGCR-SLAAGHPGYISHDKETSIKYVSHQHPSHPQLFSIVRQACVRSL 129

  Fly    92 SNGTDAS------------------KDGEFVFFGDSSRGHILSHTFRVSDLQARGYSQLFSIIVL 138
            |.....|                  ::|. :||||...|.:.||||.:.|..|||:.:.:|||.:
Human   130 SCECRESAVAALTCWFFCMLQVCPGREGP-IFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIITI 193

  Fly   139 MKDKYFLLNIKPFLAEHLKKVSSELQAAAKKTKETEEQTYSERQRRLSGA--QFLMP----TSRA 197
            |.|:.:|:|..|||...::.:..|||..|.|..|.|:....:|.:|::.|  .||..    .:|:
Human   194 MMDRIYLINSWPFLLGKVRGIIDELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARS 258

  Fly   198 LLELTGEEHIFAQLHSHFSWLLLA-GSRFLTEHVTFG---------------------------- 233
            |..||.:::::|.||:.|:|||.| ||| |||.:..|
Human   259 LTSLTSDDNLWACLHTSFAWLLKACGSR-LTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEA 322

  Fly   234 ----NLPWLPPQSSGRP----PAQRLTYNSSTLPMIESIDDPDLEEFFSLRHLKSVVRKEEFATV 290
                ..|.||..:.||.    ||:     ||:|....|.....|..|.||||::.|:....|..:
Human   323 EEEEKAPVLPESTEGRELTQGPAE-----SSSLSGCGSWQPRKLPVFKSLRHMRQVLGAPSFRML 382

  Fly   291 CYCALTGVKIVVRG-DPRKTFRFMVCLKKLLPEPMHNLMRIDAQHQ------------------H 336
            .:..|.|.:::.:. |..........|:.:||.....::...:|::                  |
Human   383 AWHVLMGNQVIWKSRDVDLVQSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPHVQIPPH 447

  Fly   337 SISSEYKII----SVSNDIAVPMA---SSSVYRIDFLDKHVNGHEVSVKWPGELPRKLPDLMVKL 394
            .:|||:.:|    :.:.....|:.   ..|:.:.:|:        |:...|....|..|.::.|:
Human   448 VLSSEFAVIVEVHAAARSTLHPVGCEDDQSLSKYEFV--------VTSGSPVAADRVGPTILNKI 504

  Fly   395 LKAVEEKNFTELVLNKQTKVLIEEWKNKVTCLNHAKSTSVQG-------KLKKVLGVQPHDQ-PI 451
            ..|:..:|.:..|:::....|.|||.|||..|  .|.|.|..       ||..:||....|. .:
Human   505 EAALTNQNLSVDVVDQCLVCLKEEWMNKVKVL--FKFTKVDSRPKEDTQKLLSILGASEEDNVKL 567

  Fly   452 INYWSTHL 459
            :.:|.|.|
Human   568 LKFWMTGL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHD	NP_648090.1	Folliculin	67..221	CDD:288541	59/177 (33%)
BHD	NP_648090.1	Folliculin_C	275..459	CDD:293297	46/217 (21%)
FLCN	NP_001340158.1	Folliculin	106..283	CDD:314549	59/177 (33%)
FLCN	NP_001340158.1	Folliculin_C	367..581	CDD:318824	47/219 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159233
Domainoid	1	1.000	99	1.000	Domainoid score	I7118
eggNOG	1	0.900	-	-		E1_KOG3715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14583
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4320
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56199
OrthoDB	1	1.010	-	-		D593097at33208
OrthoFinder	1	1.000	-	-		FOG0005615
OrthoInspector	1	1.000	-	-		oto90886
orthoMCL	1	0.900	-	-		OOG6_106566
Panther	1	1.100	-	-	LDO	PTHR31441
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770