Protein Alignment BHD and flcn-1

DIOPT Version :9

• Sequence 1: NP_648090.1
• Gene: BHD / 38793
• FlyBaseID: FBgn0261111
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_001293480.1
• Gene: flcn-1 / 174134
• WormBaseID: WBGene00017699
• Length: 626
• Species: Caenorhabditis elegans
• Alignment Length: 640
• Identity: 140/640 - (21%)
• Similarity: 228/640 - (35%)
• Gaps: 216/640 - (33%)

  Fly     1 MNAVIALCHFCEAHGPCAIFCTQTLRD-------------------------------------- 27
            |.||||||||||.|||..:...|.:||
 Worm     1 MQAVIALCHFCENHGPRVVMTCQPMRDVDDKGASCTASTSLGPSTSSSPPGIIVPLIKFDGECVV 65

  Fly    28 ---TKLED----------LSLEQQTQKTCSACNYSMGKNNNAIYSRDTESGATFVSTKVAVLPEV 79
               |..||          ......|:..||||  |..:|...:.|.|.::..:::|::||:...|
 Worm    66 KEKTNTEDGTSYPHYGNCTKFTIDTEDRCSAC--SSFRNGPCLLSNDHQTKTSYISSEVALQDRV 128

  Fly    80 ASLVKQAAVLSLS-----------------------------------------NGT-------- 95
            ...||.|.:.|||                                         :||
 Worm   129 YERVKNACLRSLSCEVSAASKKNPVQPPPPPLSRSTTPRKIHPYVIHEEPLHDFSGTRIPPSSTV 193

  Fly    96 --DASKDGEF-----------VFFGDSSRGHILSHTFRVSDLQARGYSQLFSIIVLMKDKYFLLN 147
              :..:||.|           |.|||:..|...::.||::|.:|||:.:|||:||:..|..||.|
 Worm   194 LQEPIEDGAFEQPAAEEADGYVIFGDTDNGFCFAYIFRLADAKARGFYRLFSLIVVSNDLTFLTN 258

  Fly   148 IKPFLAEHLKKVSSELQAAAKKT---------KETEEQTYSERQRRLSG-------AQFLMPTSR 196
            ...:....|..:.::||..|:..         |.:|:..:....::|.|       .:..:.|.|
 Worm   259 NFEYFKTTLGGIKNDLQKLAQDVFSREIDTGEKLSEDDIHKPEFQKLVGKMPSWYRRKIAIDTDR 323

  Fly   197 ALLELTGEEHIFAQLHSHFSWLLLAGSRFLTEHVTFGNLPWLPPQSSGRPPAQRLTYNSSTLPMI 261
            .|..:|....|:.|||.|..|.|.:.:           |..|.....|:|     |.:...|..:
 Worm   324 NLTVVTANNDIWVQLHRHMMWTLRSPT-----------LACLDQVMEGKP-----TQDMMVLLEL 372

  Fly   262 ESIDDPDLEEFFSLRH-----------LKSVVRKEEFAT-VCYCA------------LTGVKIVV 302
            |.....:||    |||           :..:...:..|| :..|:            :||.::||
 Worm   373 EESQIVELE----LRHPNQHLFGFQVSMAQLANLKIIATQLNTCSEPGDLDLLIRHIVTGGQVVV 433

  Fly   303 RGDPRKTFR-FMVCLKKLLPEPMHNLMRIDAQHQHSISSEYKIISVSNDIAVPMASSSVYRIDFL 366
            ....::..| |::.:..|||.....|.....|:....||.:.:|...:::.:|:..|     |.:
 Worm   434 ESREKEYCRQFLLAISNLLPIGCIKLATYKEQYLPEYSSRFNLIGGPHNMDIPLEVS-----DVM 493

  Fly   367 DKHVNGHEVSV----------------KWP------GELPR---KLPDLMVKLLKAVEEKNFTEL 406
            ...|:..:||:                :.|      |.|||   :..||::       :.:.|:.
 Worm   494 VFRVSPRDVSIVDIEQMSLVNCVIEVRRRPENDGSNGPLPRIVNRYRDLLL-------DSDVTDT 551

  Fly   407 VLNKQTKVLIEEW--KNKVTCLNHAKSTSVQGKLKKVLGVQPHDQPIINYWSTHL 459
            :|....:...|.|  |.|: |....|..|.....:.:.|....||.:::||:..|
 Worm   552 ILETALRTTREGWMLKAKI-CYQMTKQLSHPQVFEHITGCGVEDQQVVSYWTAGL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BHD	NP_648090.1	Folliculin	67..221	CDD:288541	54/231 (23%)
		Folliculin_C	275..459	CDD:293297	47/235 (20%)
flcn-1	NP_001293480.1	Folliculin	116..348	CDD:371680	54/231 (23%)
		Folliculin_C	408..614	CDD:374731	43/211 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166806
Domainoid	1	1.000	64	1.000	Domainoid score	I6707
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14583
Inparanoid	1	1.050	126	1.000	Inparanoid score	I3266
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56199
OrthoDB	1	1.010	-	-		D593097at33208
OrthoFinder	1	1.000	-	-		FOG0005615
OrthoInspector	1	1.000	-	-		oto20077
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31441
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R140
SonicParanoid	1	1.000	-	-		X5257
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.040