DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KMT5A and set1

DIOPT Version :9

Sequence 1:	NP_065115.3	Gene:	KMT5A / 387893	HGNCID:	29489	Length:	352	Species:	Homo sapiens
Sequence 2:	NP_587812.1	Gene:	set1 / 2538762	PomBaseID:	SPCC306.04c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	403	Identity:	85/403 - (21%)
Similarity:	148/403 - (36%)	Gaps:	105/403 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    28 GPEMVERRGPGRPRT----DGENVFTGQS----KIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQ 84
            |.|.|||...|..::    :...||:..|    |.:.:.:.:|.|..::...|.:..:..|.:..
pombe   506 GDERVERGKIGSIKSVKSDEATPVFSDTSDENDKFHRFRTKSKISKKKYEKMEVDYTSSSETESD 570

Human    85 G---KPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKD----ARKGPLVPFPNQKS--EAAEPPKT 140
            .   .|.|.|.:       :|:|::..:.|.:::|.:    |.|..:..|....|  ..|.|...
pombe   571 ASILSPSAAIPK-------SGSAIKDELISPKKEIDEVLALAPKWRINEFDETGSVYYGALPYNY 628

Human   141 PPSSC------------DSTNAAIAKQALK-----------------KPIKGKQA---------- 166
            |....            :..:.:..::|||                 |..|.|..
pombe   629 PEDDVLLDLDGLQYLVKNDEDYSYLQEALKDEPLMDINDPNFWAYERKSCKFKNGDVKYGDTAIL 693

Human   167 --PRKKAQGKTQQNRKLTDFY-----------PVRRSS---------------------RKSKAE 197
              |:...:..|..:.|...:|           |:|..|                     |:..|.
pombe   694 PEPKGYFRSNTSGSAKSEGYYIIPTTEKSLYLPLRNRSTIDTISHSTSRITSRMNRVNNRRLAAG 758

Human   198 LQSEERKRIDELIESGKEEGMKIDLIDGKGR----GVIATKQFSRGDFVVEYHGDLIEITDAKKR 258
            ::..:.....:|:.....:..|..|..|..|    |:.|.:...:.|.|:||.|::|....|..|
pombe   759 VEKSQLPAEADLLRFNALKARKKQLHFGPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNR 823

Human   259 EALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIAS 323
            |..|.::.....|::   .:.:...||||::.| :.|.||||...||..::..::|...:::.|.
pombe   824 EKNYVREGIGDSYLF---RIDEDVIVDATKKGN-IARFINHSCAPNCIARIIRVEGKRKIVIYAD 884

Human   324 RDIAAGEELLYDY 336
            |||..||||.|||
pombe   885 RDIMHGEELTYDY 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT5A	NP_065115.3	SET_SETD8	200..339	CDD:380926	42/141 (30%)
set1	NP_587812.1	RRM	<90..>226	CDD:223796
		RRM_spSet1p_like	96..180	CDD:240749
		SET_assoc	279..342	CDD:288600
		SET	457..920	CDD:225491	85/403 (21%)
		N-SET	641..771	CDD:288597	15/129 (12%)
		SET	783..899	CDD:214614	40/119 (34%)
		PostSET	904..920	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910