DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	777	Identity:	180/777 - (23%)
Similarity:	283/777 - (36%)	Gaps:	192/777 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 GRQLPSSGRVEDTLVVPRVSRENRGMYQ---CVV----------RRPEGDTFQATAELQLGDAPP 423
            |..|..||.....|   |:.:...|:.:   |:|          |..||..:..:.:.|
Human     6 GAGLRCSGIASSPL---RMQQNELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQ------ 61

  Fly   424 VLLYSFIEQTLQPGPAVSLKCSAAGNPTPQ----ISWTLDGFPLPSNGRFMIG--QYITVHGDVI 482
                   :|.:..|..|:|.|:     .|:    :.|..||..| ..||.:..  ||:.| |:.:
Human    62 -------DQVVVSGQPVTLLCA-----IPEYDGFVLWIKDGLAL-GVGRDLSSYPQYLVV-GNHL 112

  Fly   483 S---HVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLI---PKVTAVSGETLNLKC 541
            |   |:.|....::|...|.|.|...|.| ...|||.:...|...:|   |.::..:|:.|||.|
Human   113 SGEHHLKILRAELQDDAVYECQAIQAAIR-SRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTC 176

  Fly   542 PV-AGYPIEEIHWERGGRE----------LPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNK 595
            .. ...|...|.|.|.|..          |.|..|:.:.  .:|.|||....:...: .|.|.||
Human   177 HADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV--STLFISPGDVENGQSI-VCRATNK 238

  Fly   596 QGHSARRSGEVTVIV--PP--KLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDP 656
            .....:.: .||:.:  ||  .||.....:|:.|:   .:..||...........|.|.|:.|..
Human   239 AIPGGKET-SVTIDIQHPPLVNLSVEPQPVLEDNV---VTFHCSAKANPAVTQYRWAKRGQIIKE 299

  Fly   657 TQHMSVKQVDQYNSILVIENLGSDHTGNY-----SCVVRNSAAEVENSQALLVNVPPRWIVEPVD 716
            ...      :.|.:.:       |:|  |     ||.|.|:......|:.:.|...||...||..
Human   300 ASG------EVYRTTV-------DYT--YFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQS 349

  Fly   717 ANVERNRHIMLHCQAQGVPTPSIVW-KKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREG 780
            ..|:.....:..|...|.|:.:||| |:.:|              ..|....:|.|:.|:::..|
Human   350 LLVDLGSDAIFSCAWTGNPSLTIVWMKRGSG--------------VVLSNEKTLTLKSVRQEDAG 400

  Fly   781 FYLCQA-NNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAV-SGDKPINIVWMRSG 843
            .|:|:| ...:|.| .:.:.|.||..|..||| ::.....|:...::|.: |...|..|.|...
Human   401 KYVCRAVVPRVGAG-EREVTLTVNGPPIISST-QTQHALHGEKGQIKCFIRSTPPPDRIAWSWK- 462

  Fly   844 KNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATD-SGPYFCRASNLYGNDQQLVQLQVQEPPL 907
            :|.|...|:.:.:|:..:|.:||.:.|.|..:...| ...|.|.|.|.:|:|.::::|:.|...:
Human   463 ENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEM 527

  Fly   908 PPS-------------------------VLEAAMI------SSRSVNIKWQPKTLGT-------- 933
            ...                         ||.|.::      |.||...:......||
Human   528 KSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRL 592

  Fly   934 -------------GDVTKYIVEFREA------DHSLPPALFVDQWQ--------QIEV--KDPPH 969
                         .|:...||....|      :||....|.:|:.:        |:||  ::...
Human   593 PRRANLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKE 657

  Fly   970 FNAMIENLKPATR--YAFRVIAEGSAGRSAPSQELIVRTEPQRPAGP---PLSLSARPLSST 1026
            |    :|||..|.  |:.....|   ..|.|:..|.......||||.   |..:|...:.||
Human   658 F----QNLKDPTNGYYSVNTFKE---HHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYST 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	12/58 (21%)
		IGc2	344..407	CDD:197706	10/47 (21%)
		IG_like	432..517	CDD:214653	28/93 (30%)
		IGc2	436..507	CDD:197706	22/79 (28%)
		I-set	521..610	CDD:254352	26/102 (25%)
		IGc2	533..597	CDD:197706	21/74 (28%)
		Ig	630..699	CDD:143165	14/73 (19%)
		IG_like	714..802	CDD:214653	21/89 (24%)
		Ig	725..802	CDD:299845	19/78 (24%)
		Ig	823..894	CDD:143165	20/72 (28%)
		FN3	906..1006	CDD:238020	29/169 (17%)
		FN3	1013..1111	CDD:238020	5/17 (29%)
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	29/111 (26%)
		IG_like	60..149	CDD:214653	29/109 (27%)
		I-set	156..249	CDD:254352	23/96 (24%)
		Ig2_KIRREL3-like	171..252	CDD:143236	22/84 (26%)
		Ig_2	260..337	CDD:290606	19/94 (20%)
		I-set	341..422	CDD:254352	24/95 (25%)
		IGc2	355..406	CDD:197706	15/64 (23%)
		Ig5_KIRREL3	424..521	CDD:143306	26/98 (27%)
		IG_like	432..521	CDD:214653	22/89 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810