DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and CNTN2

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_024305154.1 Gene:CNTN2 / 6900 HGNCID:2172 Length:1200 Species:Homo sapiens


Alignment Length:1386 Identity:324/1386 - (23%)
Similarity:497/1386 - (35%) Gaps:347/1386 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 GPGFVMEPPGRV--EFSNSSGGWLDCSASGSPQPTVDWVHADGSAVTEIHGVRRVLRNGTLVLM- 91
            ||.|..:|...:  |.|......|.|.|..||..|..| ..:|:.:....|.|..|..|.||:| 
Human    49 GPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRW-KMNGTEMKLEPGSRHQLVGGNLVIMN 112

  Fly    92 PFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVAQAY-KVDVEVLSAARGCTAILRCVVP 155
            |..|    ||.  .:|:|:|||.||.:|||:..:|....|.: |.:.:.:.|..|...:|.|..|
Human   113 PTKA----QDA--GVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPP 171

  Fly   156 TFVKELVRVVSWVHEPAIYI------YPS-LQGDGK-FHLLPTGELLIHNLQESDESQSFRCRSM 212
                        .|.|.:..      :|: :..||: |....||.|.|.....||.. ::.|.: 
Human   172 ------------AHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLA- 222

  Fly   213 HRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWFTHNGA 277
                             .||....:.||....|.:.::.::                        
Human   223 -----------------TSHMDFSTKSVFSKFAQLNLAAED------------------------ 246

  Fly   278 GPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRLTVATPIQVEISPNVLSV 342
                      .||..|                    ::.....||....|...:.:|        
Human   247 ----------TRLFAP--------------------SIKARFPAETYALVGQQVTLE-------- 273

  Fly   343 HMGGTAEFRCLVTSNGSPVGMQNILWYK-DGRQLPSSGRVEDTLVVPRVSRENRGMYQCVVRRPE 406
                     |....|..|    .|.|.| ||...|.....|.||.:|.||.|:.|.|:|.....:
Human   274 ---------CFAFGNPVP----RIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSK 325

  Fly   407 G-DTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFM 470
            | ||.|....:|   |.|..|....:.....|..:...|:|||.|.|.:.|..:|.||.|..|..
Human   326 GRDTVQGRIIVQ---AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVE 387

  Fly   471 IGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGL-------PYIRLIPK 528
            :     :.||    :..|.:.:||.|.|.|:|||:.|.:..:|.|.:..|       |..|||| 
Human   388 V-----LAGD----LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIP- 442

  Fly   529 VTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWAR 593
             .|..||.| :.|.....|...:.|.:|...|.:..|..|.|||:|.|..:.: ||.|.|||:|.
Human   443 -AARGGEIL-IPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISR-SDEGKYTCFAE 504

  Fly   594 NKQGHSARRSGEVTVIVPPK--LSPFQTNILQLNMGDRASLTCSVVKG-DLPLTINWRKDGRPID 655
            |..| .|..:|.::|....|  |:|...:|   |:||..:|.|..... .:.||..|..|..|||
Human   505 NFMG-KANSTGILSVRDATKITLAPSSADI---NLGDNLTLQCHASHDPTMDLTFTWTLDDFPID 565

  Fly   656 ---PTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDA 717
               |..|.....|.:....|.|.|....|.|.|:|:.:...........:||..||    .|...
Human   566 FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPP----GPPGG 626

  Fly   718 NVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFY 782
            .|.|:         .|..|..:.|.:...:.|         |..|                   |
Human   627 VVVRD---------IGDTTIQLSWSRGFDNHS---------PIAK-------------------Y 654

  Fly   783 LCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTL 847
            ..||..   ...||..|::.|.:..           :|:....|  |.|..|    ||       
Human   655 TLQART---PPAGKWKQVRTNPANI-----------EGNAETAQ--VLGLTP----WM------- 692

  Fly   848 NPSTNYKI-----SVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPL 907
                :|:.     ::.....|.|.|:  :|||.:|.                          |.:
Human   693 ----DYEFRVIASNILGTGEPSGPSS--KIRTREAA--------------------------PSV 725

  Fly   908 PPSVLEAAMISSRSVNIKWQP--KTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEV--KDPP 968
            .||.|.....:...:.:.|.|  :....||...|::.||....:        .||...|  .|..
Human   726 APSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGST--------HWQTARVPGADAQ 782

  Fly   969 HFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWV 1033
            :|....|:::|.|.:..::.:....|....|...:|.:..:.|...|..:.|:.:||:|:.::| 
Human   783 YFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTW- 846

  Fly  1034 APLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQV 1098
            .|:.:..:|.:.||.:.|..:.....|.:....:|......    :|||....:|.|.|:|:|:.
Human   847 EPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSAR----VSGLHPNTKYHVTVRAYNRA 907

  Fly  1099 GPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDI 1163
            |.||.|....|.||:..|.|||.::.. ..||.||.:.|.|...:.....:.|||::::   :|:
Human   908 GTGPASPSANATTMKPPPRRPPGNISW-TFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ---NDL 968

  Fly  1164 QPSKDEVESRKTTALTMVLTGLRKYTNYSI-QVLAHTRM--------GDGVVSKPLFCHSEEDVP 1219
            ..:.           |:.||| :.:....: :.:.|..:        |||:.::.....:....|
Human   969 HLTP-----------TLHLTG-KNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGAAP 1021

  Fly  1220 EAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGL 1284
            ..|...:.:....:.|..|:  |..|..:.|:...:..   ||.::.:..|: .|...:|.|...
Human  1022 PLPLSPREIQDPPRYLRGSF--PPRPTPISTRKGKWKA---GRNQVQSSLRT-ASPPPFYPAPRT 1080

  Fly  1285 HPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVG---KP 1346
            .|            |..||:  ||..:....  ||        :....:|||     .||   .|
Human  1081 SP------------RAREGR--RVQGEAEDQ--PA--------IANGLQSTV-----GVGLRRPP 1116

  Fly  1347 KREWFKSDVALRQ--GGLHNS 1365
            .|......:||.:  ||.|.|
Human  1117 SRPLPGLQLALHKHDGGEHGS 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 29/76 (38%)
Ig 138..>203 CDD:299845 16/72 (22%)
I-set 238..327 CDD:254352 8/88 (9%)
Ig 247..327 CDD:299845 5/79 (6%)
I-set 332..418 CDD:254352 24/87 (28%)
IGc2 344..407 CDD:197706 19/63 (30%)
IG_like 432..517 CDD:214653 27/84 (32%)
IGc2 436..507 CDD:197706 24/70 (34%)
I-set 521..610 CDD:254352 33/88 (38%)
IGc2 533..597 CDD:197706 23/63 (37%)
Ig 630..699 CDD:143165 19/72 (26%)
IG_like 714..802 CDD:214653 15/87 (17%)
Ig 725..802 CDD:299845 12/76 (16%)
Ig 823..894 CDD:143165 14/75 (19%)
FN3 906..1006 CDD:238020 21/103 (20%)
FN3 1013..1111 CDD:238020 26/97 (27%)
FN3 1119..1209 CDD:238020 20/98 (20%)
FN3 1219..1313 CDD:238020 19/93 (20%)
Ig 1336..1402 CDD:143165 11/35 (31%)
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
CNTN2XP_024305154.1 Ig 49..142 CDD:325142 35/99 (35%)
Ig2_Contactin-2-like 144..241 CDD:143204 25/127 (20%)
Ig 252..337 CDD:325142 28/125 (22%)
Ig4_Contactin-2-like 341..425 CDD:143205 28/92 (30%)
Ig5_Contactin 446..518 CDD:319278 26/74 (35%)
Ig6_Contactin-2 537..616 CDD:143262 20/78 (26%)
FN3 631..718 CDD:238020 25/156 (16%)
FN3 739..813 CDD:238020 16/81 (20%)
FN3 828..920 CDD:238020 26/96 (27%)
Atrophin-1 <1002..1197 CDD:331285 37/171 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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