DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and ROBO3

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_071765.2	Gene:	ROBO3 / 64221	HGNCID:	13433	Length:	1386	Species:	Homo sapiens

Alignment Length:	1662	Identity:	348/1662 - (20%)
Similarity:	519/1662 - (31%)	Gaps:	622/1662 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 PSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRV-RLLGPILAI---E 298
            |.:||....:.||:.|.|.|.|.|:|.|.|...|: .|||....|...||. |||.|..|:   .
Human    64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWY-KNGARVATVREDPRAHRLLLPSGALFFPR 127

  Fly   299 AVTGE----DSGVYKCTAGN-VGGEASAELRLTVATPIQVEI--SPNVLSVHMGGTAEFRCLVTS 356
            .|.|.    |.|||.|.|.| :|..||....|.||. ::.:.  ||..:.|.:|..|...| |..
Human   128 IVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV-LRDDFRQSPGNVVVAVGEPAVLEC-VPP 190

  Fly   357 NGSPVGMQNILWYKDGRQL-PSSGRVE---DTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQ 417
            .|.|  ..::.|.|||.:| ...||:.   ..|::....:.:.|||.||.....|:...|.||:.
Human   191 RGHP--EPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVM 253

  Fly   418 LGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVI 482
            :.:.|..|.....:..|...| |:..|...|:|.|::.|..:...||: ||:.|..
Human   254 VLERPSFLRRPVNQVVLADAP-VTFLCEVKGDPPPRLRWRKEDGELPT-GRYEIRS--------- 307

  Fly   483 SH-VNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPK-VTAVSGETLNLKCPVAG 545
            .| :.|.||..||.|.|.|:|||..||.:.:..|:::..|.:...|: ..|..||::..:|...|
Human   308 DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKG 372

  Fly   546 YPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIV 610
            .|...|.|::.|.::.....|.:||.|..::||                 :|
Human   373 NPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSP-----------------RG------------- 407

  Fly   611 PPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIE 675
                   |.||..:..||.....|                       |.:||.     .|||
Human   408 -------QLNITAVQRGDAGYYVC-----------------------QAVSVA-----GSIL--- 434

  Fly   676 NLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIV 740
                            :.|.:|...|.|..:||..:..|.:..:.....:.|.|:..|.|.||:.
Human   435 ----------------AKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVR 483

  Fly   741 WKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSS 805
            ||     |.|::.:..:..| |.:.||:|.:.:|:|...|||.|.|.:..|
Human   484 WK-----KDGQWLQGDDLQF-KTMANGTLYIANVQEMDMGFYSCVAKSSTG-------------- 528

  Fly   806 PYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAEL 870
                                :...||       |::..::.                  |||.:
Human   529 --------------------EATWSG-------WLKMREDW------------------GVSPD- 547

  Fly   871 QIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGD 935
                                       ...:...||..||......|:..|:.:.|:|.......
Human   548 ---------------------------PPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAA 585

  Fly   936 VTKYIVEFREADHSLPPALFVDQWQQIE--VKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAP 998
            ||.|::|      :..||. .:.|:.:.  |:...|   .:..|:|.|.|.|.|.|.|:.|.|.|
Human   586 VTSYVIE------AFSPAA-GNTWRTVADGVQLETH---TVSGLQPNTIYLFLVRAVGAWGLSEP 640

  Fly   999 SQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNF 1063
            |
Human   641 S---------------------------------------------------------------- 641

  Fly  1064 TSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPED------ 1122
                                                  |:|||  .:|.:..||||.||
Human   642 --------------------------------------PVSEP--VRTQDSSPSRPVEDPWRGQQ 666

  Fly  1123 ------VRC---AALSSQSLQVSWQ-PPPIYHTNGLLQGYKLIFE---------PIIDDIQPSKD 1168
                  ||.   ..|..::|||||. ..|:.    |:||:::.:.         .::|...||:.
Human   667 GLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQ----LVQGFRVSWRVAGPEGGSWTMLDLQSPSQQ 727

  Fly  1169 EVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPAD---IKVVSS 1230
                      :.||.||...|...|:|.|..:.|.|..|..:.....|:.|..|..   :.:...
Human   728 ----------STVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGD 782

  Fly  1231 SSQSLYISWLP--PNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHMEYQFW 1293
            .:.|:.:||.|  |::.|||||:|.::......|..||   ||..........:||.|.:.|:..
Human   783 GNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLN---RSAAGWARSAMLRGLVPGLLYRTL 844

  Fly  1294 VTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKREWFKSDVALR 1358
            |.|:|..|.|             :|:      .||:      |.||.....:|
Human   845 VAAATSAGVG-------------VPS------APVL------VQLPSPPDLEP------------ 872

  Fly  1359 QGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPVLYVTSATSSS 1423
              ||                          :|..|:.. ||...|      ..|.....|..:..
Human   873 --GL--------------------------EVGAGLAV-RLARVL------REPAFLAGSGAACG 902

  Fly  1424 ILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCGSTYQIHLSAQNKVGTS 1488
            .|:...|.          .|::||    ....:||.:.:|.         .|...:|..:..|.|
Human   903 ALLLGLCA----------ALYWRR----KQRKELSHYTASF---------AYTPAVSFPHSEGLS 944

  Fly  1489 PTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPDNGCPLLYFVLQYRAVTDDPDAEWVL 1553
                       |.|...|..   |.|...|.|.  .|||.              .:..|.|:
Human   945 -----------GASSRPPMG---LGPAPYSWLA--DSWPH--------------PSRSPSAQ--- 976

  Fly  1554 VSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDPPPPEIMHRGRSGQTT 1618
                 :|:.....:|..|...|      :|.||||.    ::..|..|...|.|
Human   977 -----EPRGSCCPSNPDPDDRY------YNEAGISL----YLAQTARGTAAPGE----------- 1015

  Fly  1619 VIFANINLLIPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESLENRANSEAAQRERY 1683
                            ..::.||              .|..|:.|
Human  1016 ----------------GPVYSTI--------------DPAGEELQ-------------------- 1030

  Fly  1684 YATIHKVSMQNNDKIPETSEDISPYATFQLSE-AGGNMSQPHHGGPANTLLHSFMYHERALAEGC 1747
              |.|....|:      .|.|:.|::.:...| :.|:...  .||....|............|..
Human  1031 --TFHGGFPQH------PSGDLGPWSQYAPPEWSQGDSGA--KGGKVKLLGKPVQMPSLNWPEAL 1085

  Fly  1748 SSPPPAASKN-----RRRHSRKTEPE------------SEESESDQDQLTSSRTESSNQHEGKIK 1795
            ..|||:...:     .......:|||            :|.|.|....:|.||.|:.:....
Human  1086 PPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPS--- 1147

  Fly  1796 HSIIYHGAQSSTSSDLSP---------MSEQKSLPRR 1823
                 :|.||:.:...||         |.....:|||
Human  1148 -----YGQQSTATLTPSPPDPPQPPTDMPHLHQMPRR 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	38/97 (39%)
		Ig	247..327	CDD:299845	35/88 (40%)
		I-set	332..418	CDD:254352	26/91 (29%)
		IGc2	344..407	CDD:197706	19/66 (29%)
		IG_like	432..517	CDD:214653	28/85 (33%)
		IGc2	436..507	CDD:197706	24/71 (34%)
		I-set	521..610	CDD:254352	18/89 (20%)
		IGc2	533..597	CDD:197706	14/63 (22%)
		Ig	630..699	CDD:143165	9/68 (13%)
		IG_like	714..802	CDD:214653	24/87 (28%)
		Ig	725..802	CDD:299845	23/76 (30%)
		Ig	823..894	CDD:143165	6/70 (9%)
		FN3	906..1006	CDD:238020	28/101 (28%)
		FN3	1013..1111	CDD:238020	4/97 (4%)
		FN3	1119..1209	CDD:238020	29/114 (25%)
		FN3	1219..1313	CDD:238020	27/98 (28%)
		Ig	1336..1402	CDD:143165	10/65 (15%)
		FN3	1409..1498	CDD:238020	14/88 (16%)
		FN3	1515..1588	CDD:238020	14/72 (19%)
ROBO3	NP_071765.2	Ig	64..162	CDD:299845	38/98 (39%)
		I-set	64..161	CDD:254352	38/97 (39%)
		I-set	168..249	CDD:254352	23/83 (28%)
		Ig	170..254	CDD:299845	26/86 (30%)
		I-set	258..343	CDD:254352	30/95 (32%)
		Ig	275..343	CDD:299845	26/77 (34%)
		I-set	347..441	CDD:254352	31/177 (18%)
		Ig	361..450	CDD:299845	31/172 (18%)
		I-set	451..531	CDD:254352	25/119 (21%)
		IGc2	465..528	CDD:197706	22/68 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..563		7/67 (10%)
		FN3	556..649	CDD:238020	32/206 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..662		13/126 (10%)
		FN3	680..760	CDD:238020	24/93 (26%)
		FN3	770..863	CDD:238020	29/120 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..989		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1310		35/190 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1327..1386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010