DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and DSCAML1

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens


Alignment Length:2172 Identity:666/2172 - (30%)
Similarity:1023/2172 - (47%) Gaps:241/2172 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65
            ||:.:   .:|||.:|.....|.....|.   ||.:...:|.||:|.|..:.|.|:|||...:.|
Human     1 MWLVT---FLLLLDSLHKARPEDVGTSLY---FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRW 59

  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130
            ..|.|..:.::..:|.|..||||.|.||:.:|::..:|:..|.|.|.|:.|:|.|.:::|:||..
Human    60 YLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFR 124

  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195
            :.|.|.||...:.||..|:.:|::|:.|:|.|.|||| .:..:.|.|    :.:|.:...|.|.|
Human   125 EPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSW-EKDTVSIIP----EHRFFITYHGGLYI 184

  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIIS--------------PSVVEHTAH 246
            .::|:.|...::||.:.|:.:.:...|:..||.:.   |:..              |::::....
Human   185 SDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT---GLARAADPLCLPDPAESIPTILDGFHS 246

  Fly   247 VQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCT 311
            .:|.......|.|.|.|.|.|...|.  ....|||..|....|:.|  |.|..:..||||.|.|.
Human   247 QEVWAGHTVELPCTASGYPIPAIRWL--KDGRPLPADSRWTKRITG--LTISDLRTEDSGTYICE 307

  Fly   312 AGNVGGEASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGR-QL 375
            ..|..|.|.|...|.|..|:.|.::|..|...:|.|....|.:|  |||  ...|.||::.. .|
Human   308 VTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT--GSP--EFTIRWYRNTELVL 368

  Fly   376 PSS-----GRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQ 435
            |..     |...:||::....:.:.|.|||...| :..|.|..|.:.|.|..|.::.||.|:.:.
Human   369 PDEAISIRGLSNETLLITSAQKSHSGAYQCFATR-KAQTAQDFAIIALEDGTPRIVSSFSEKVVN 432

  Fly   436 PGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYAC 500
            ||...||.|:|.|.|.|.::|.||..|:..:|.....||....|..|||:|::...:.|||.|.|
Human   433 PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC 497

  Fly   501 IAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIR 565
            .|.|..|..::.||:|:.|.|.||.:..:|||:|....:.|.|.|||...|.|.:....|||:.|
Human   498 TARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR 562

  Fly   566 QRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRA 630
            |.|..:|:|.::.|||..|.|.|.|....:...|..:|..|.|.|||.:.||:  ....::|...
Human   563 QVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE--FPPASIGQLL 625

  Fly   631 SLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAE 695
            .:.|.|..||:|:.|.|||||:.|.....::::. .::.|.|.|.::...|.|||:|:..|:||.
Human   626 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIES-KEFMSSLQISSVSLKHNGNYTCIASNAAAT 689

  Fly   696 VENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPF 760
            |...:.|:|.||||::|:|.:.:....:..:|:|...|.|.|.::||.|.|  ||..::....|.
Human   690 VSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG--SGNPQQYHPVPL 752

  Fly   761 T---KLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDT 822
            |   ::|.|.|||::||.|:..|:|||||:||:||.|.|.:.|.|......:|...:.:..||..
Human   753 TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHA 817

  Fly   823 ALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRA 887
            ..|.|...|::||.|.| ..|...::|....:.::..:...|.|.:.|:::..|..||..:.|.|
Human   818 KELNCTARGERPIIIRW-EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 881

  Fly   888 SNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPP 952
            .|.||.|:.|:||.|||||.||. ||...:.:||:|::|..:..|...:|.:.:|::...     
Human   882 INSYGEDRGLIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKS----- 940

  Fly   953 ALFVDQW---QQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGP 1014
                |.|   |......|....|.|.:|.||:.|:.|:.:....|||.||:||.:.||...|.||
Human   941 ----DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGP 1001

  Fly  1015 PLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSG-NTAYNFTSVSGDGDGGNGELL 1078
            |:.::.:|::|..:.::|.||..||::|.|:||.:||:.:|.| |..|:...:...||  :....
Human  1002 PMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD--SEVYT 1064

  Fly  1079 LSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIY 1143
            |..|.|||:|.|||||||:.|.||.|....|.|:|||||:|||:||..:::|....:||..||..
Human  1065 LDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRS 1129

  Fly  1144 HTNGLLQGYKLIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSK 1208
            ..||:|:||::||..:.  :.....|:::..||...:.|.|:.|:||||:||||:|:.||||.|.
Human  1130 TLNGVLKGYRVIFWSLY--VDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSS 1192

  Fly  1209 PLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLP 1273
            .|:..::||||..||.||.|.||:.|:.:|||||.:|||||.||:::.......:...:|..:.|
Human  1193 VLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP 1257

  Fly  1274 SQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTL 1338
             :|.:|....|:...:|..||.|.|..|.|.||...:.....:.||:||||||.|..||...|.|
Human  1258 -EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1321

  Fly  1339 PCTAVGKPKR--EWFK----SDVALRQGG---LHNSQLLDSGDLIISSLQLADGGNYSCQVDNGI 1394
            ||.:||.|..  :|.|    |.:.:...|   :|.     :|.|::.:::..|.|.|:|...|..
Human  1322 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-----NGTLLLRAVKAEDSGYYTCTATNTG 1381

  Fly  1395 GTDRLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQ--- 1456
            |.|.:...|:|||||..|.|.|:..::|||.:.|..|..|.:.|.|:.|.|  :..|::|.:   
Human  1382 GFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQY--SVDNSEEWKDVF 1444

  Fly  1457 LSRHASSHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLL 1520
            :|....|.:|..|.||:.|::.|:|:|.||:...|.|:..:|.|:.|.......|... |||...
Human  1445 ISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHAR 1509

  Fly  1521 VRLHSWPDNGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVA 1585
            :.|..|.:.|||:...||:||     |...|............:.:..|:.:|.|:|||.|.|.|
Human  1510 LNLQGWNNGGCPITAIVLEYR-----PKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSA 1569

  Fly  1586 GISQAEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYR- 1649
            |.......|.||..||...||....:|.......:|   .:..|.|.|..|:  .::.|:...| 
Human  1570 GCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLF---TIGCPVILATLGV--ALLFIVRKKRK 1629

  Fly  1650 ----HMLKNAPPLAEQSQIQKESLENRANSEAA----QRERYYATIHKVSMQNNDK--------- 1697
                ..|::|..|||. .|.|   .||:.....    |..|.:..|.:|.:...||         
Human  1630 EKRLKRLRDAKSLAEM-LISK---NNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDD 1690

  Fly  1698 ---IPETSEDISPYATFQLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPP---PAASK 1756
               ||.|..:.|.....|....|.::..|       ||:.|    ...|.:.....|   |.:.|
Human  1691 KATIPVTDAEFSQAVNPQSFCTGVSLHHP-------TLIQS----TGPLIDMSDIRPGTNPVSRK 1744

  Fly  1757 N-RRRHSRKTEPESE------ESESDQDQLTS-----------------SRTESSNQHEGKIKHS 1797
            | :..||.:....|:      ::.:....|||                 |.:.|.:|...|.::|
Human  1745 NVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNS 1809

  Fly  1798 IIYHGAQSSTSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTAT 1862
            ::...:.|||..:|:...|...|    ..:..|.:::. |.......:|::|...|  |.|..:.
Human  1810 MVSTESASSTYEELARAYEHAKL----EEQLQHAKFEI-TECFISDSSSDQMTTGT--NENADSM 1867

  Fly  1863 NTTATPSTSSNSNKILSP-------RGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQ---- 1916
            .:.:|||.........||       ||.|: ::....::..|..|::|...||.:...:..    
Human  1868 TSMSTPSEPGICRFTASPPKPQDADRGKNV-AVPIPHRANKSDYCNLPLYAKSEAFFRKADGREP 1931

  Fly  1917 ------KQFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNS 1975
                  ::...:.|..:....::|.:.:|.|.||....|                     |...:
Human  1932 CPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHP---------------------GAPAA 1975

  Fly  1976 PLVACMPPSSQFRPIPHKSIMPAHEPPHHHNHSQQSHPHQQQQQQQHPG-TLLNPSTAMLSSKFF 2039
            ...|.:|..:...|.|     ||...|                  ..|| |...|.||..:    
Human  1976 ASTATLPQRTLAMPAP-----PAGTAP------------------PAPGPTPAEPPTAPSA---- 2013

  Fly  2040 TAPTLPKXDTANGGSEY--VGGAMEAM 2064
             ||..|. :....|..:  :||:.:::
Human  2014 -APPAPSTEPPRAGGPHTKMGGSRDSL 2039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 27/75 (36%)
Ig 138..>203 CDD:299845 20/64 (31%)
I-set 238..327 CDD:254352 28/88 (32%)
Ig 247..327 CDD:299845 27/79 (34%)
I-set 332..418 CDD:254352 26/91 (29%)
IGc2 344..407 CDD:197706 20/68 (29%)
IG_like 432..517 CDD:214653 31/84 (37%)
IGc2 436..507 CDD:197706 28/70 (40%)
I-set 521..610 CDD:254352 33/88 (38%)
IGc2 533..597 CDD:197706 23/63 (37%)
Ig 630..699 CDD:143165 24/68 (35%)
IG_like 714..802 CDD:214653 35/90 (39%)
Ig 725..802 CDD:299845 34/79 (43%)
Ig 823..894 CDD:143165 20/70 (29%)
FN3 906..1006 CDD:238020 30/102 (29%)
FN3 1013..1111 CDD:238020 40/98 (41%)
FN3 1119..1209 CDD:238020 37/89 (42%)
FN3 1219..1313 CDD:238020 35/93 (38%)
Ig 1336..1402 CDD:143165 21/74 (28%)
FN3 1409..1498 CDD:238020 30/91 (33%)
FN3 1515..1588 CDD:238020 24/72 (33%)
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653 26/75 (35%)
IGc2 43..110 CDD:197706 23/66 (35%)
Ig 125..218 CDD:299845 30/97 (31%)
IG_like 137..209 CDD:214653 23/76 (30%)
I-set 245..323 CDD:254352 27/81 (33%)
IGc2 252..313 CDD:197706 22/64 (34%)
IGc2 340..401 CDD:197706 19/64 (30%)
I-set 420..514 CDD:254352 35/93 (38%)
Ig 420..510 CDD:299845 33/89 (37%)
IGc2 531..589 CDD:197706 23/57 (40%)
IG_like 619..698 CDD:214653 26/79 (33%)
Ig 627..693 CDD:143165 24/66 (36%)
I-set 702..797 CDD:254352 38/96 (40%)
Ig7_DSCAM 719..797 CDD:143211 34/79 (43%)
I-set 803..896 CDD:254352 27/93 (29%)
Ig 815..903 CDD:299845 30/88 (34%)
FN3 899..993 CDD:238020 31/103 (30%)
FN3 1000..1097 CDD:238020 40/98 (41%)
fn3 1105..1191 CDD:278470 36/87 (41%)
FN3 1203..1294 CDD:238020 35/91 (38%)
IGc2 1318..1382 CDD:197706 19/68 (28%)
FN3 1396..1486 CDD:238020 30/91 (33%)
FN3 1500..1572 CDD:238020 24/76 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4888
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 968 1.000 Inparanoid score I322
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47134
OrthoDB 1 1.010 - - D10185at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8541
orthoMCL 1 0.900 - - OOG6_101656
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1391
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.980

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