DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and cntn3a.1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_697914.4	Gene:	cntn3a.1 / 569437	ZFINID:	ZDB-GENE-081030-10	Length:	1028	Species:	Danio rerio

Alignment Length:	1417	Identity:	296/1417 - (20%)
Similarity:	484/1417 - (34%)	Gaps:	470/1417 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWISSRFFVILLLLNLDNTCSEPFE-AHLRGPGFVM------EPPGRVEFSNSSGGWLDCSASGS 58
            |.:|.:..|:.|.:...:..|.|.. ...:.||.::      ||...|.||        |.|.|.
Zfish     1 MGLSWKLLVLQLFMGCLSDGSGPLRPVFTKQPGSIVFPLHLNEPSREVTFS--------CEAQGR 57

  Fly    59 PQPTVDWVHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDV 123
            |.|:..|...| |.::...|.|..:..|.|.:     :..:::....||:|:||||.|.|:||:.
Zfish    58 PPPSYRWKMND-SFISPQPGSRYSISGGNLRI-----SQLNKEEDAGIYQCLASNSFGTILSREA 116

  Fly   124 QVRAVVAQAYKVDV-EVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSL--QGDGKF 185
            .:.....:.:|..: ..:....|...:|.|..|.::.||  ..||:...    |||.  |...:|
Zfish   117 SLHIAYLEEFKTQMRSPVRVREGQGVVLLCGPPAYMGEL--TFSWIFNE----YPSFVEQDTRRF 175

  Fly   186 HLLPTGELLIHNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVS 250
            ....||.|.|..::.||.. ::.|         ||.::.|:.|:
Zfish   176 VSQKTGNLYIAKVEPSDVG-NYTC---------VVTNTVTQNRV--------------------- 209

  Fly   251 QDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNV 315
                       ||.|:|                         .||..:.:.||    |:
Zfish   210 -----------QGPPTP-------------------------LILRSDGIMGE----YE------ 228

  Fly   316 GGEASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSGR 380
                         ..|:|:. |.||:|..|.|
Zfish   229 -------------PKIEVQF-PEVLAVAKGLT--------------------------------- 246

  Fly   381 VEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCS 445
                                                                       |.|:|.
Zfish   247 -----------------------------------------------------------VKLECF 252

  Fly   446 AAGNPTPQISWTL-DGFPLP-------SNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA 502
            |.|||.|.|||.. ||.|.|       |:|                .:.|.:...||.|.|.|:|
Zfish   253 ALGNPVPAISWRRPDGVPFPRKVDVSKSSG----------------VLEIPYFQQEDAGPYECVA 301

  Fly   503 ENRAGRVQHAARLNIYGLPYIRLIPK-VTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQ 566
            ||..|:.....||:.|..|::...|: |.....|:|..:|..:..|.....|.:.|..| :....
Zfish   302 ENSRGKNTGKGRLSFYAPPHLVEKPQDVQRAIDESLLWECKASAKPKPSYRWLKNGEPL-ESFED 365

  Fly   567 RVQP-DGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRA 630
            |:|. :|:|:||.:.. ||:|:|.|.|.|:.|.....:....:.|.|..|
Zfish   366 RIQVINGALSISSLTL-SDTGMYQCIAENRHGRVFANAELRVIAVAPDFS--------------- 414

  Fly   631 SLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENL---GSDHTGNYSCVVRNS 692
                                                  ||:|..:.|   |.|
Zfish   415 --------------------------------------NSVLKAQTLARQGGD------------ 429

  Fly   693 AAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRE 757
                                            :::.|:.:..|...|.|:|..       |.:||
Zfish   430 --------------------------------VLIECRPRMSPRGMISWRKGK-------EALRE 455

  Fly   758 RPFTKLLGNGSLLLQHVKEDREGFYLCQANN--GIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKG 820
            .....:|.||||.:.::.:...|.|.|.|.|  |:.:..|.::   |......:|.:..:.|..|
Zfish   456 SHRVSVLDNGSLRISNITKLDAGLYTCVARNQFGVASSAGTLV---VKEPTIITSKATQLDVTVG 517

  Fly   821 DTALLQCAVSGDKPINI--VWMRSGKNTLNPSTN--YKISVKQEATPDGVSA-ELQIRTVDATDS 880
            ::.::.|.||.|..:::  .|. ..:..:|..::  |...|      .|.|| ::.||.:....:
Zfish   518 ESVVIPCQVSRDPSLDVRFTWF-FNEQLINFGSHGGYFEKV------GGASAGDIMIRNIQLRHA 575

  Fly   881 GPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFR- 944
            |.|.|.......:......:.|:.||.||..:....::..:..:.|.|.......|..|.::.|
Zfish   576 GRYTCAVQTKVDSASIATDVVVRGPPDPPLDIRVDEVTETTSFVSWSPGPDNHSPVFAYNIQIRS 640

  Fly   945 ------EADHSLPPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGR---SAPSQ 1000
                  :|..::|.:|...|           .:|.:..|.|...|.|||:|..|.|.   :.|||
Zfish   641 PFSLGWQAAKTVPESLGGQQ-----------SSARVVELSPWVEYEFRVLATNSIGTGEPTKPSQ 694

  Fly  1001 ELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRH-GDIQGYNVGYK-----------L 1053
            :  :||:...|...|..:|....|.:||:|:| .|:||.:. |...||.|.::           :
Zfish   695 K--IRTKDTMPRITPARVSGGGGSRSELVITW-EPVPEEQQAGPGFGYVVAFRPLGGQNWMQAAV 756

  Fly  1054 SSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSR 1118
            :|...:.|.|.:.|              :..|:.:.|.|..:|..|.||....|...:.|:.|||
Zfish   757 TSPDASRYIFKNDS--------------IPPFSPFHVKVGVYNNKGEGPFGPVTTIYSAEEEPSR 807

  Fly  1119 PPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESRKTTALTMVLT 1183
            .|..:|..:||:..::|||:|.|...:...:.||:|.:....|  :|....|........:.|:.
Zfish   808 APSRIRAKSLSASEVEVSWKPLPWSTSRTRIMGYELRYWSTKD--RPDTASVMRTVGNRTSAVIR 870

  Fly  1184 GLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSSQS-LYISWLPPNEPNG 1247
            ||...:.|:|::.|:...|.|..|..:...::.. |.:.:.:||:.:::.| |.:.|
Zfish   871 GLDPSSTYNIKLKAYNSAGVGPDSAVVNVTTKRP-PPSQSPVKVMWNTTDSKLILKW-------- 926

  Fly  1248 VITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHM----------------EYQFWVTA 1296
                        :..:.|.||...:..:..|.:::...|.:                :|...:..
Zfish   927 ------------DHVKALENESEVMGYKVMYKQSRQTRPSVVETNSTSLELSLPVDEDYIIQIKP 979

  Fly  1297 STRVGEGKSSRVSSQITTNRIP-ARIISFGGPVVRPWRS------TVTLPCT 1341
            .:..|||.||:   |||..||. |..|.|.     |.|.      |:.|.||
Zfish   980 VSEGGEGSSSK---QITIPRIAVAHAIGFA-----PERKALPVFVTLVLHCT 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	23/75 (31%)
		Ig	138..>203	CDD:299845	18/66 (27%)
		I-set	238..327	CDD:254352	9/88 (10%)
		Ig	247..327	CDD:299845	9/79 (11%)
		I-set	332..418	CDD:254352	7/85 (8%)
		IGc2	344..407	CDD:197706	2/62 (3%)
		IG_like	432..517	CDD:214653	29/92 (32%)
		IGc2	436..507	CDD:197706	26/78 (33%)
		I-set	521..610	CDD:254352	24/90 (27%)
		IGc2	533..597	CDD:197706	20/64 (31%)
		Ig	630..699	CDD:143165	6/71 (8%)
		IG_like	714..802	CDD:214653	20/89 (22%)
		Ig	725..802	CDD:299845	20/78 (26%)
		Ig	823..894	CDD:143165	16/75 (21%)
		FN3	906..1006	CDD:238020	25/109 (23%)
		FN3	1013..1111	CDD:238020	26/109 (24%)
		FN3	1119..1209	CDD:238020	24/89 (27%)
		FN3	1219..1313	CDD:238020	18/110 (16%)
		Ig	1336..1402	CDD:143165	3/6 (50%)
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
cntn3a.1	XP_697914.4	I-set	26..120	CDD:254352	30/107 (28%)
		Ig	26..117	CDD:299845	30/104 (29%)
		Ig	122..217	CDD:299845	29/167 (17%)
		IG_like	132..206	CDD:214653	22/89 (25%)
		Ig	229..317	CDD:299845	37/196 (19%)
		I-set	229..309	CDD:254352	35/188 (19%)
		I-set	320..406	CDD:254352	24/87 (28%)
		Ig	323..406	CDD:299845	23/84 (27%)
		IG_like	421..499	CDD:214653	23/131 (18%)
		Ig	427..499	CDD:299845	22/125 (18%)
		IG_like	514..597	CDD:214653	18/89 (20%)
		Ig	518..601	CDD:299845	17/89 (19%)
		FN3	601..698	CDD:238020	25/109 (23%)
		FN3	707..799	CDD:238020	26/106 (25%)
		FN3	808..901	CDD:238020	24/94 (26%)
		FN3	916..994	CDD:238020	16/100 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010