DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and il1rapl1a

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_021334418.1	Gene:	il1rapl1a / 568868	ZFINID:	ZDB-GENE-061013-249	Length:	1520	Species:	Danio rerio

Alignment Length:	1530	Identity:	272/1530 - (17%)
Similarity:	424/1530 - (27%)	Gaps:	616/1530 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 NYSCVVRNSAAEVENSQAL-----LVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKK 743
            |.:...|.:...|::||.:     |..||           |..|.|::|:...........:.|.
Zfish    19 NCNSAPRGTKIVVQSSQKVEAFSSLFYVP-----------VRVNGHVILNGMIDSGSMACTISKH 72

  Fly   744 ATG--SKSG---EYEEVRERPFTKLLGNGSLLLQHVKEDREGFY-------------LCQANNG- 789
            |..  |.:|   |.:...|:  ..|:|.|.   |..:.|  |||             .|....|
Zfish    73 AVEKISSAGILPEKKHSEEK--IVLIGCGG---QQTQPD--GFYDLEIQFFDTRCVAPCLVVPGQ 130

  Fly   790 -----IGTGIGK--VIQLKVNSSPYFSSTSR-----------------SVMVKKGDTA------- 823
                 :|:.|.|  :.:|| |::.|:...||                 .|...||||.
Zfish   131 RDDLILGSNIIKHLIHELK-NNNDYWDIASRPDNKFDEDVQQFLSMFTGVERWKGDTVPDKIGTV 194

  Fly   824 -LLQCAVSGDKPINIVWMRSGKN-----------------------------------------T 846
             |.|..|...|..::||.|...|                                         .
Zfish   195 KLTQAVVLLPKHEHLVWGRLPSNVPMSPGSTVIVEPTNSKAMPRDILVGRLVVPLWGDRWVPMTV 259

  Fly   847 LNPSTNYKISVKQ-----EATPDGVSAELQI-----------RTVDATDSGPYFCRASNLYGNDQ 895
            :|| ||..|::|:     :..|...|.:.:|           ::.|:.:|    |.|.::   |:
Zfish   260 MNP-TNKVITLKRNSKMADVFPCIASEDFEIFQGLHITLVENKSDDSCNS----CAADHI---DK 316

  Fly   896 QLVQLQVQEPPLPPSVLEAAMISSRSVNIKW-QPKTLGTGDVTKYIVEFRE--ADHSLPPALFVD 957
            .|:.|.::|                 :::.| |........:|:.:.::::  :.|.|.......
Zfish   317 NLLNLGLEE-----------------IDVNWSQISDDCKSQLTQLLADYQDIFSKHPLDCGEATG 364

  Fly   958 QWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARP 1022
            ...:|.:.|...|......:.||.....|.:.      :...::.|:|......|.|
Zfish   365 YVHRIRLTDNRPFRLPYRRVPPAHYEKLRQVL------TDMEEKGIIRKSSSEYASP-------- 415

  Fly  1023 LSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFAR 1087
                 |::.|                                    ..|||            .|
Zfish   416 -----LVMVW------------------------------------KKDGG------------LR 427

  Fly  1088 YTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGY 1152
            .....:..|            |:||:|....|.:....|||....         .:.|..|..|:
Zfish   428 ICTDFRWLN------------ARTMKDAHPLPHQADCLAALGGNC---------FFSTMDLTSGF 471

  Fly  1153 KLIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKP-------- 1209
            ..|         |..:  |.:|.||.|..| ||.:|          .||..|:.:.|
Zfish   472 YNI---------PMSE--EDKKYTAFTTPL-GLHEY----------NRMPQGLCNSPASFMRMML 514

  Fly  1210 ----------LFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREE 1264
                      |.|:.::.:..||::.:.:|.                         .|.|..|..
Zfish   515 GIFGDLNFSKLLCYLDDLLVFAPSESEALSR-------------------------LRTVFDRLR 554

  Fly  1265 LNNEKRSLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVV 1329
            .||.|              |.|.                |...:.||:   |....||..||..|
Zfish   555 ENNLK--------------LSPK----------------KCHLLQSQV---RFLGHIIDSGGVSV 586

  Fly  1330 RPWRSTVTLPCTAVGKPKREWFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGI 1394
            .|.:..|....||                    |:  |:|:           ||    |
Zfish   587 DPAKVEVITRMTA--------------------HD--LMDN-----------DG----C------ 608

  Fly  1395 GTDRLTHTLIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSR 1459
                           |..|..:.|                   ..|...:|:....|...:
Zfish   609 ---------------TPSVKRIKS-------------------FLGMVFYYQHFIPNCSSI---- 635

  Fly  1460 HASSHELKGLMCGSTYQIHLSAQNKV-GTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRL 1523
               |..|.||..|...:..||.:.|. ||....|.....|:.|.......||||     ..::..
Zfish   636 ---SKPLFGLTAGQKRRGKLSKERKFQGTYRKLTPADWTTECQVAFDKLKTALL-----ECVMLA 692

  Fly  1524 HSWPDNGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGIS 1588
            |  ||...|   |:|...|..|...|....|.......|.|...:...|| .|.|..||.:
Zfish   693 H--PDFNEP---FILSVDASLDGLGAVLSQVPKGELQARPIAFASKTLST-SQRRYPAHRL---- 747

  Fly  1589 QAEF-----------------NFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSG 1636
              ||                 :..|:..|.:|             .|.|.....|....:..||.
Zfish   748 --EFMALKWSVCEKFSHWLKGHKFTIWTDNNP-------------LTYILTKPKLDAYELRWVSK 797

  Fly  1637 MFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESLENRANSEAAQR----ERYYATIHKVSMQNNDK 1697
                    :..|...||:.|   .::.:..::|......|...|    |.|...:.:.|....|.
Zfish   798 --------LAAYTFDLKHLP---GKANVVADTLSRDPFVEPIGRRLLNEPYSYLMQEASGIGEDS 851

  Fly  1698 IPET------------SEDISPYATFQLSEAGGNMSQPH---HGGPANTLLHSFMYHERALAEGC 1747
            :.:.            .|.:|....:.:.|... :.|.|   ..|..:..||  :.|...:..||
Zfish   852 VHDVFRVSSHIQPNQPMECLSQSVDYNVDEVKA-LCQSHCSWTDGAESRALH--LVHHVQMISGC 913

  Fly  1748 SSPPPAASKNRRRHSRKTEPESEESESDQDQLTSS---------RTESSNQHEG----------- 1792
            ....|..|            ..|..:|.|:.||.|         |..|..:..|
Zfish   914 QETLPVLS------------AQELKDSQQEDLTISKVLSFLIRQRRPSRRERHGASAQVIRLLKQ 966

  Fly  1793 ----KIKHSIIYHGAQSSTSSDLSPMSEQK--------SLPRRGRSRYH----HQQYQFSTNTTP 1841
                :::..::|...:       .|::::|        ||..:..|..|    ||....:.:...
Zfish   967 WSKLEVRDDVLYRVTK-------DPLTKRKRLQYVLPDSLRNKALSGIHDLAGHQGQDRTISLAR 1024

  Fly  1842 RHHNSNKMNNNTTSNTNTTATNTTA-TPSTSSNSNKILSPRGGNLKSISST----------FKSQ 1895
            :......|..|.............| :|..::.:         .|::|.||          :.::
Zfish  1025 QRFYWPDMEKNIREYVQCCRRCVLAKSPEPAARA---------PLENIKSTAPMELVCIDFWSAE 1080

  Fly  1896 DSIQCHIPTLVKSPSI---------STQQQKQFHKQQLQN----SSTNNSQHSSSNPNSSSLKQQ 1947
            :|.||.:..||.:...         :.|..||..|:...|    .......||....|..|
Zfish  1081 NSKQCSVDVLVVTDHFTKLAHAFPCANQTAKQVAKKLWDNVFCIYGFPERIHSDQGTNFES---- 1141

  Fly  1948 QPLLITPKLHQLEANGQELLGLDGIGNSPLVACMP 1982
                      .|.|   |||.|.|:..|...|..|
Zfish  1142 ----------NLIA---ELLRLAGVAKSHTTAYHP 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352
		IGc2	533..597	CDD:197706
		Ig	630..699	CDD:143165	3/14 (21%)
		IG_like	714..802	CDD:214653	24/113 (21%)
		Ig	725..802	CDD:299845	21/102 (21%)
		Ig	823..894	CDD:143165	21/135 (16%)
		FN3	906..1006	CDD:238020	12/102 (12%)
		FN3	1013..1111	CDD:238020	9/97 (9%)
		FN3	1119..1209	CDD:238020	21/89 (24%)
		FN3	1219..1313	CDD:238020	14/93 (15%)
		Ig	1336..1402	CDD:143165	9/65 (14%)
		FN3	1409..1498	CDD:238020	17/89 (19%)
		FN3	1515..1588	CDD:238020	18/72 (25%)
il1rapl1a	XP_021334418.1	retropepsin_like	46..137	CDD:133136	22/108 (20%)
		RT_LTR	403..579	CDD:238825	54/337 (16%)
		RNase_HI_RT_Ty3	701..823	CDD:260006	28/152 (18%)
		rve	1068..1176	CDD:307008	24/113 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910