DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and hmcn2

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_001920501.5 Gene:hmcn2 / 565032 ZFINID:ZDB-GENE-030131-9765 Length:4212 Species:Danio rerio


Alignment Length:2383 Identity:522/2383 - (21%)
Similarity:802/2383 - (33%) Gaps:759/2383 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDWVHADGSAVTEIH 77
            ||||..|..:|..                         |.|.|.|.|.||:.|. .|...|.|..
Zfish  1347 LLNLTVTLKQPLT-------------------------LGCDAFGIPTPTISWT-KDNRPVLETP 1385

  Fly    78 GVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVG---RIVSRDVQVRAVVAQAYKVDVEV 139
            ||  .|:||..:|..:..    |..|...:.|.|.||.|   |..:.:||...|::....|....
Zfish  1386 GV--YLQNGKRLLKIYRV----QHDHAGRFSCTAQNSAGEAKREYTIEVQAPPVISGTSGVQEVT 1444

  Fly   140 LSAARGCTAILRCVV-----PTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELL-IHNL 198
            :.|  |....::|.|     |:        |.|.|:..:.   |..||.....|..|::| :.::
Zfish  1445 IMA--GQEVDMQCRVSGRPLPS--------VEWTHDGEVL---SPNGDPHVEFLEKGQVLRVKSV 1496

  Fly   199 QESDESQSFRCRSMHRL---TRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEG--AVLL 258
            :..|.. .::|.:.:..   |||.      ||.|.:     :|.:.:.....:|:...|  |||.
Zfish  1497 RPRDRG-LYQCVATNNAGTQTRQF------RLTIQA-----APLIRDSGEDSEVTVVLGFPAVLH 1549

  Fly   259 CVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLL--GPILAIEAVTGEDSGVYKCTAGNVGGEASA 321
            |..:|.|.|..:|...|    .|::|.|::...  |..|.:.|..|||:|.|.|.|.|..|.|..
Zfish  1550 CEVEGIPLPTITWLKDN----QPIVSSPQLTYTQGGQSLRVAAARGEDAGAYTCRATNPAGTAHR 1610

  Fly   322 ELRLTVATPIQVEISPNVLS-------VHMGGTAEFRCL-------------------------- 353
            ...|.:..|.|:|....:||       |.:.||....||                          
Zfish  1611 HYTLRIMVPPQIEGDSTILSFGRREEKVRINGTLTLSCLAKGFPEPVTQWFKDGQLLNGNTHSGL 1675

  Fly   354 ----------------------VTSNG-------------------------------------- 358
                                  |.||.                                      
Zfish  1676 SVNSHMLHVDNAMLSHEGQYTCVVSNSAGEDKRDFHLTIQVPPVFHRVINGAADFTLGEREGDEE 1740

  Fly   359 ---SPVGM-----------------------QNILWYKDGRQLPSSGRV-----EDTLVVPRVSR 392
               ||.||                       ..:.||:.||||.||..|     ...|.:|||..
Zfish  1741 DPDSPDGMVERREVLLGHSISLSCESNAIPPPRLSWYRQGRQLTSSDGVVLAPGGHILQIPRVQL 1805

  Fly   393 ENRGMYQC-VVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQP-----GPAVSLKCSAAGNPT 451
            |:.|.|.| .|.....|......|:.:   ||| :....::.:|.     ...|||:|..:|:|:
Zfish  1806 EDAGKYTCQAVNEAGEDKMHYDLEVLV---PPV-ISGQTDEFMQDVDTVVNSTVSLRCDVSGHPS 1866

  Fly   452 PQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRV------- 509
            |.:||..||.||.|:.|    ..|...|.::..||   |.|.||..|.|:|||:||.|       
Zfish  1867 PSVSWIKDGLPLYSDSR----HNILEDGKLLEIVN---VQVSDGASYQCVAENKAGAVERLYSLS 1924

  Fly   510 ----------------------------------------------------------------- 509
                                                                             
Zfish  1925 IQVPPRIVGRREEEMSVVEGHMISLLCDVQAYPPADIIWTKDGQMLEFTTGIHILPGGQMLQIPR 1989

  Fly   510 --------------------QHAARLNIYGLPYIRLIPKV-------TAVSGETLNLKCPVAGYP 547
                                |.:..|.||.||  .|:|::       |.:.|.||.|:|...|.|
Zfish  1990 AGQQDAGQYVCTATNSAGQDQKSILLTIYALP--ALVPRLESESEVRTPLVGSTLILRCEANGIP 2052

  Fly   548 IEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPP 612
            ..|:.|.|.|.:|......|::.. .|.|..||. :|.|||||...|..| ...|:..|||.|||
Zfish  2053 KPEVTWYRNGLQLAAGNGLRIERQ-QLEIVGVQV-ADGGVYTCKVSNIAG-QVDRTFRVTVHVPP 2114

  Fly   613 KL-SPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYN-----SI 671
            .: .|....:.| |:|...:|.|......:| .|.|.|||.||:.:.        |:|     :.
Zfish  2115 VMEGPLHETLTQ-NLGSHITLICEASGIPVP-NIAWLKDGSPIESSL--------QWNWSTRANR 2169

  Fly   672 LVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVE---PVDANVERNRHIMLHCQAQG 733
            |.:..|...|.|.|:|:.:|:..:.:...:|.:..||. |::   |.:.:......:.|.|:|.|
Zfish  2170 LELGPLQLSHAGTYTCIAKNTEGQTQKDYSLTIYAPPS-IIDSGHPSEVSAPVGEELALECRAMG 2233

  Fly   734 VPTPSIVW-KKATGSKSGEYEEVRERPFTKLLGNGS-LLLQHVKEDREGFYLCQANNGIG--TGI 794
            .|.|.:.| :......:|..|.:...|      :|| |....||.:..|.|.|.|.:..|  |.|
Zfish  2234 SPAPKVSWLRNGKTLVNGNTEHINISP------DGSTLTFLSVKPEDSGTYTCLAVSSAGQETKI 2292

  Fly   795 GKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQ 859
            ..:..|...|....:|..|.|...:.....|:|...|.....|.|:|.| :.|..|...::    
Zfish  2293 YTLFALVPPSISGETSVPREVHTTQHSVVTLECKAKGTPQPQISWLRDG-HPLLLSPRIRL---- 2352

  Fly   860 EATPDGVSAE--LQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPP----LPPSVLEAAMIS 918
                  :||:  |:|..|..:|||.|.|.|.:..|..:....||||.||    ..|:. :.|::.
Zfish  2353 ------LSADSTLRISPVHLSDSGIYTCVARSRAGLAELNFDLQVQAPPAVERTEPTE-QVAVVQ 2410

  Fly   919 SRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDPP----HFNAMIE---- 975
            ..||.:..                  ||....||.|   .|    :||..    |.|.:::    
Zfish  2411 GSSVTLTC------------------EARGVPPPTL---SW----LKDGQPLSLHRNLLLDGQET 2450

  Fly   976 -----NLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAG---------------------- 1013
                 ::.|:....:..:|...||.|..:..|.| .||.:..|                      
Zfish  2451 RFLLSDVGPSDAGLYSCVASNQAGSSTKTFNLTV-LEPPKITGSLSPEEQLIAVDSLLELECIAT 2514

  Fly  1014 --PPLSLS----ARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDG 1072
              ||.:||    .||:.....:|.....|  ||...:|..:.|.           :|.::....|
Zfish  2515 GLPPPTLSWLKDGRPIQDNMAIIERDGQL--LRINKVQVEDAGL-----------YTCLASSPAG 2566

  Fly  1073 GNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSW 1137
            .:|.          .:.|.||.     |..|......:|: .||::....:.|...|....::.|
Zfish  2567 EDGR----------NHWVRVQL-----PPTLLGSNDIRTV-SVPAKGHLTLECQTDSDPPPEIEW 2615

  Fly  1138 QPPPIYHTN------GLLQGYKLIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTN--YSIQ 1194
                 |..|      |.:|.   |......:||    :|....:...:.|:|.:...|:  ::::
Zfish  2616 -----YKDNVKVQLGGRIQS---IASGQFLEIQ----DVRMHDSGQYSCVVTNIAGSTSLFFTVE 2668

  Fly  1195 VLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVV 1259
            :|....:.:|  |..:..|..:|. ..|.:::...|||    :.|                 |..
Zfish  2669 ILLPPVIREG--SSLIIAHVGQDA-VLPCEVEGAPSSS----VMW-----------------RKD 2709

  Fly  1260 NGREELNNEKRSLPSQQA-------------YY-----EAKGLHPHMEYQFWVTASTRVGEGKSS 1306
            .|...|:|.:.:|.|:.:             ||     :|...|..|:.:.:|..|...|     
Zfish  2710 GGPVPLHNNRFTLLSEGSLRISTVQLSDVGRYYCSVSNQAGSDHRGMDLKVYVGPSISPG----- 2769

  Fly  1307 RVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKREWFK--SDVALRQGGLHNSQLLD 1369
                            .|...||...|:.::...|.:..|:..|.:  |.:::.|...:  :|:.
Zfish  2770 ----------------PFNVTVVTGQRAVLSCESTGIPAPQVSWRRNGSPISVDQSSAY--RLMS 2816

  Fly  1370 SGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTA--PVLYVTSATSSSILMHWKCGF 1432
            ||.|:|:|....|.|.:.|.|.|.:|.:|....:|:||||..  .|..||:...|.:::  .|..
Zfish  2817 SGSLVITSPTAEDEGYFECTVTNEVGEERRVIEVILQVPPVIKDDVSSVTAVKMSPVVL--PCHA 2879

  Fly  1433 TGN-APITGYTLFYRRANGNTDEMQLSRHASSH--------ELKGLMCGSTYQIHLSAQNKVGTS 1488
            ||. .|:..:         |.:.|||.....|:        |:.........:...||:|.||.:
Zfish  2880 TGRPEPVISW---------NKNWMQLGARGGSYRVLPTGALEILAATPSHAGKYTCSARNPVGVA 2935

  Fly  1489 PTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLH-----------------SWPDNGCPLLYF 1536
                ..||....|.|..      :.|.:..:.|.||                 :|...|.|:   
Zfish  2936 ----YKHVTLTVQEPPE------IRPMAEEVQVVLHHSVVLPCEVQGFPRPTITWQREGVPV--- 2987

  Fly  1537 VLQYRAVTDDPDAEWVLVSNALKPQR---------RIVINNLQPSTL--YQLRMEAHNVAGISQA 1590
            ...:|..        ||.:.|||..|         :.:..|...:.|  .||.::...|..:.:.
Zfish  2988 ATGHRLA--------VLSNGALKFSRVTLGDAGTYQCLAQNEAGTALAQTQLILQVPPVLSVPRL 3044

  Fly  1591 EFNFV-------TLTKDGDPPPPEIMHRGR----SGQTTVIFANINL-LIPTIAAVSGMF-CTII 1642
            |:..|       ....||.|.|....||.|    ......:|:|.:| :..|....:|:: |:..
Zfish  3045 EYVVVLGQPVSLDCVADGQPKPEVTWHRDRRPVVDSSHLRLFSNGSLHITATQRGDAGIYTCSAR 3109

  Fly  1643 MIIVCYRH---MLKNAPP-----LAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIP 1699
            ..:....|   ::.:.||     .:|.|.:|...:.....::.....|.......||:.|   :|
Zfish  3110 NSVGRASHDVRLILHTPPQIFVGQSEISVMQGLRVMLPCAAQGVPEPRMSWEKKGVSVSN---MP 3171

  Fly  1700 ETSEDISPYATFQLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPPPAASKNRRRHSRK 1764
                     ..|.|.|:||.:.:....|.|....             |.:...|.|  .|...|.
Zfish  3172 ---------GKFTLRESGGLIIERAEAGDAGLFT-------------CVATNTAGS--ARWDIRL 3212

  Fly  1765 T---EPESEESESDQDQLTSSRTES---SNQHEGKIKHSII-------YHGAQSSTSSDLSPMSE 1816
            |   .|..:|...|   :|.::.:|   |...||....:|.       |.||             
Zfish  3213 TVNMRPAFKELPGD---VTLNKGQSLSLSCHAEGTPTPTITWTANNRPYTGA------------- 3261

  Fly  1817 QKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNT---TATNTTATPSTSSNSNKIL 1878
              |:...|||                   |...:|.|.|:..|   .|.||.             
Zfish  3262 --SVDETGRS-------------------SVIFDNVTVSDGGTYACIAENTV------------- 3292

  Fly  1879 SPRGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQKQFHKQQLQNSSTNNSQHSSSNPNSSS 1943
                |.::::|       .::...|.:::..:.::|       ..:|..|.......|.:|..|.
Zfish  3293 ----GLIRALS-------FVRVREPPVLRGEAHTSQ-------TVIQGKSAMLDCAVSGDPVPSL 3339

  Fly  1944 L--KQQQPLLITPKLHQLEANGQELLGLDGIGNSPLVACMPPS 1984
            .  |..||||.:.:.|.|. ||...|....||:|....|:..|
Zfish  3340 RWHKDGQPLLGSLRFHPLR-NGSLALYSAIIGDSGEYRCVAES 3381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 27/78 (35%)
Ig 138..>203 CDD:299845 14/70 (20%)
I-set 238..327 CDD:254352 29/92 (32%)
Ig 247..327 CDD:299845 28/83 (34%)
I-set 332..418 CDD:254352 36/210 (17%)
IGc2 344..407 CDD:197706 29/180 (16%)
IG_like 432..517 CDD:214653 34/181 (19%)
IGc2 436..507 CDD:197706 28/75 (37%)
I-set 521..610 CDD:254352 33/95 (35%)
IGc2 533..597 CDD:197706 24/63 (38%)
Ig 630..699 CDD:143165 19/73 (26%)
IG_like 714..802 CDD:214653 24/91 (26%)
Ig 725..802 CDD:299845 23/80 (29%)
Ig 823..894 CDD:143165 21/72 (29%)
FN3 906..1006 CDD:238020 22/116 (19%)
FN3 1013..1111 CDD:238020 21/125 (17%)
FN3 1119..1209 CDD:238020 17/97 (18%)
FN3 1219..1313 CDD:238020 19/111 (17%)
Ig 1336..1402 CDD:143165 18/67 (27%)
FN3 1409..1498 CDD:238020 22/99 (22%)
FN3 1515..1588 CDD:238020 18/100 (18%)
hmcn2XP_001920501.5 VWA_2 38..208 CDD:290253
IG 441..512 CDD:214652
Ig 441..502 CDD:299845
I-set 516..603 CDD:254352
Ig 533..600 CDD:143165
IG 613..691 CDD:214652
Ig 624..690 CDD:143165
IG 710..784 CDD:214652
Ig 714..781 CDD:143165
IG 794..879 CDD:214652
Ig 794..879 CDD:299845
I-set 885..972 CDD:254352
Ig 904..972 CDD:299845
IG_like 982..1063 CDD:214653
IGc2 989..1053 CDD:197706
IG_like 1083..1159 CDD:214653
Ig 1089..1156 CDD:143165
I-set 1163..1241 CDD:254352
IGc2 1176..1231 CDD:197706
Ig 1244..1327 CDD:299845
IG_like 1258..1335 CDD:214653
Ig 1338..1430 CDD:299845 32/114 (28%)
I-set 1344..1428 CDD:254352 31/112 (28%)
IG_like 1441..1523 CDD:214653 21/101 (21%)
IGc2 1448..1513 CDD:197706 15/76 (20%)
IG_like 1536..1616 CDD:214653 28/83 (34%)
IGc2 1545..1606 CDD:197706 23/64 (36%)
IG_like 1638..1714 CDD:214653 8/75 (11%)
Ig 1644..1711 CDD:143165 5/66 (8%)
IG_like 1753..1830 CDD:214653 19/76 (25%)
Ig 1760..1822 CDD:143165 18/61 (30%)
I-set 1834..1918 CDD:254352 33/91 (36%)
Ig 1851..1925 CDD:299845 31/80 (39%)
IG_like 1937..2017 CDD:214653 2/79 (3%)
IGc2 1943..2007 CDD:197706 0/63 (0%)
IG_like 2031..2110 CDD:214653 28/81 (35%)
IGc2 2039..2100 CDD:197706 24/62 (39%)
I-set 2114..2202 CDD:254352 25/97 (26%)
IGc2 2129..2192 CDD:197706 20/71 (28%)
IG 2214..2295 CDD:214652 23/86 (27%)
IGc2 2222..2287 CDD:197706 19/70 (27%)
I-set 2307..2391 CDD:254352 25/94 (27%)
IGc2 2321..2381 CDD:197706 20/70 (29%)
I-set 2400..2484 CDD:254352 20/109 (18%)
IGc2 2410..2474 CDD:197706 14/88 (16%)
IG_like 2496..2576 CDD:214653 16/102 (16%)
IGc2 2507..2566 CDD:197706 13/71 (18%)
IG 2589..2669 CDD:214652 17/92 (18%)
IGc2 2597..2659 CDD:197706 13/73 (18%)
IG 2679..2760 CDD:214652 19/102 (19%)
IGc2 2687..2750 CDD:197706 14/84 (17%)
I-set 2764..2851 CDD:254352 24/109 (22%)
Ig 2770..2845 CDD:299845 21/76 (28%)
IG 2863..2943 CDD:214652 20/94 (21%)
Ig 2873..2942 CDD:299845 17/83 (20%)
IG_like 2954..3032 CDD:214653 16/88 (18%)
IGc2 2963..3023 CDD:197706 11/70 (16%)
IG_like 3046..3122 CDD:214653 15/75 (20%)
IGc2 3051..3113 CDD:197706 13/61 (21%)
IG_like 3133..3214 CDD:214653 20/107 (19%)
Ig 3144..3213 CDD:299845 17/95 (18%)
IG 3224..3303 CDD:214652 24/139 (17%)
IGc2 3232..3293 CDD:197706 20/111 (18%)
IG_like 3316..3394 CDD:214653 21/74 (28%)
IGc2 3321..3384 CDD:197706 20/62 (32%)
TSP1 3401..3452 CDD:214559
G2F 3455..3636 CDD:284812
EGF_CA 3691..3721 CDD:214542
Furin-like 3728..3857 CDD:279142
EGF_CA 3731..3774 CDD:284955
EGF_CA 3776..3814 CDD:214542
EGF_CA 3816..3849 CDD:238011
EGF_CA 3858..3899 CDD:284955
EGF_CA 3901..3940 CDD:214542
EGF_CA 4005..4044 CDD:214542
EGF_CA 4045..4085 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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