DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and lrit3a

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_001122166.1 Gene:lrit3a / 558559 ZFINID:ZDB-GENE-080723-63 Length:636 Species:Danio rerio


Alignment Length:501 Identity:106/501 - (21%)
Similarity:158/501 - (31%) Gaps:191/501 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   529 VTAVS-GETLNLK----CPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVY 588
            :|:|. |...|||    ..:.|..|....||                  ||...|..|..|.   
Zfish    93 ITSVDPGSFYNLKVLHELRLDGNMIATFPWE------------------SLKEMPSLKTLDL--- 136

  Fly   589 TCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDL-----PLTINWR 648
                     |:.|.:.     ||.:.:|:..||..|   |.:|...:.:..||     |.:    
Zfish   137 ---------HNNRLTS-----VPVEAAPYLINITYL---DISSNKLTTLPSD
LVDIWPPFS---- 180

  Fly   649 KDGRPIDPTQHMSVKQV-------------------------------DQYNSILVIENLGSDHT 682
                .|.|:.:.|.|.|                               ||     |:...|.:|.
Zfish   181 ----GIQPSANTSQKTVLGLQDNPWYCDCRISKLIELSKMAGIPVVLMDQ-----VLTCSGPEHL 236

  Fly   683 GNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGS 747
            ..    |....||::......|......|..|:.:||      :|.|.|.|.|||:::|..|.||
Zfish   237 SG----VLFQRAELDQCVKPTVMTSATKITSPLGSNV------LLRCDANGFPTPTLLWTTADGS 291

  Fly   748 KSGEYEEVRERPFTKLLGNG---SLLLQH--VKEDREGFYLCQANNGIGTGIGKVIQLKVN---- 803
            .... ..|:|.|     |.|   |:|..|  |.:| .|.|.|:|.|..|.. ...|.|.|:    
Zfish   292 VVNN-TVVQESP-----GEGVRWSILSLHSIVFKD-AGDYRCKAKNVAGNA-EAYITLSVDGVQP 348

  Fly   804 ------------------------SSPYFSS------TSRSVMVKKGDTALLQCAV--------- 829
                                    ..|.|:|      |:|.||.........:..:         
Zfish   349 TTPFPPINITKQPEDQPTTTFTPTKMPLFTSLSPITITTRPVMTTMPPLTTRKSPIPGGGVQRSP 413

  Fly   830 -SGDKPINIVWMRSGKNTLNPSTNYKISVKQEAT--------PDGVSAELQIRTV----DATDSG 881
             :||||..:...::||.::..|....|.|.:|.|        .:|:.::..:..|    ||.|  
Zfish   414 PAGDKPAKVQQSKNGKGSIKKSDIRDIEVVEETTETAVLLWSAEGLPSDTPLTVVYFPYDAKD-- 476

  Fly   882 PYFCRASNLYGNDQQLVQLQVQEPPL------PPSVLEAAMISSRS 921
                        |::.|..:|.:..|      |..|....:::..|
Zfish   477 ------------DKETVDTEVGQGKLLLEYLMPNQVYTVCLVTKSS 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352
Ig 247..327 CDD:299845
I-set 332..418 CDD:254352
IGc2 344..407 CDD:197706
IG_like 432..517 CDD:214653
IGc2 436..507 CDD:197706
I-set 521..610 CDD:254352 17/85 (20%)
IGc2 533..597 CDD:197706 13/68 (19%)
Ig 630..699 CDD:143165 17/104 (16%)
IG_like 714..802 CDD:214653 32/92 (35%)
Ig 725..802 CDD:299845 29/81 (36%)
Ig 823..894 CDD:143165 16/92 (17%)
FN3 906..1006 CDD:238020 4/22 (18%)
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
lrit3aNP_001122166.1 LRR_8 81..141 CDD:290566 16/77 (21%)
leucine-rich repeat 83..106 CDD:275378 5/12 (42%)
LRR_4 107..145 CDD:289563 11/72 (15%)
leucine-rich repeat 107..130 CDD:275378 6/40 (15%)
LRR_8 129..>171 CDD:290566 13/61 (21%)
LRR_4 129..170 CDD:289563 13/60 (22%)
leucine-rich repeat 131..154 CDD:275378 7/39 (18%)
leucine-rich repeat 155..168 CDD:275378 4/15 (27%)
TPKR_C2 199..249 CDD:301599 8/58 (14%)
Ig 252..343 CDD:299845 34/104 (33%)
IG_like 261..343 CDD:214653 33/95 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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