DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and sdk1b

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_017211454.1	Gene:	sdk1b / 555553	ZFINID:	ZDB-GENE-090311-17	Length:	2292	Species:	Danio rerio

Alignment Length:	1800	Identity:	429/1800 - (23%)
Similarity:	682/1800 - (37%)	Gaps:	425/1800 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 VSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIE----QTLQPGPAVSLKCSAAGN- 449
            :.||:.|:|||.||...|...|..|::::     ..:.:|.|    :|:..|.|..|...|..:
Zfish   224 LKREDAGVYQCAVRNRMGALIQTRADVRV-----AYMDNFAELEQRKTVSQGRAAVLNPPAVTSF 283

  Fly   450 PTPQISWTLDGFPLPSNGRFMI----------------GQYITVHGDVISHVNISHVMVEDGGE- 497
            |.||::|..||..:..|.|..|                |:|      .:..||      |..||
Zfish   284 PRPQVTWFRDGVKIIPNHRVAITLDNQLVVLSTAAADAGRY------YVQAVN------ERNGEN 336

  Fly   498 ------YACIAENRAGRVQHAARLNIYGL--PYIRLIPKVTAV--SGETLNLKCPVAGYPIE--E 550
                  |..||.|:..|...|..:....|  |.|.:.||.|:|  ......|:|......::  :
Zfish   337 KTSPSIYLSIAINKRNRGSLADVIAPAELVAPVIVIAPKNTSVVAGASEATLECVANARSLDRLQ 401

  Fly   551 IHWERGGRELP---DDIRQRVQPDGSLTIS-PVQKNSDSGVYTCWA--RNKQGHSARRSGEVTVI 609
            :.|:|.|..|.   |...:|      |.|| |.  ::|.|:|.|.|  ||....|......::|:
Zfish   402 VFWKRNGVRLTAGVDSFGRR------LVISNPT--SADGGLYVCEATLRNSSQKSTEAKAYLSVL 458

  Fly   610 VPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVI 674
            ..|..:......:...:.....|.|. .||.....:.|.||..|:. |.:.|..::...:.:|.:
Zfish   459 ESPHFTSKPKRYMIAEVEKNVELQCH-AKGVPTPKLEWFKDAIPLS-TLNNSRYKLTTSSMVLQV 521

  Fly   675 ENLGSDHTGNYSCVVRNSAAEVE-NSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPS 738
            ..:..|..|.:.|...|:|.|:: ::..::.::.|.:...|.|..|......:..|...|.|.|:
Zfish   522 RRIQPDDAGIFQCFAENTAGEIQAHTNLVITSMSPLFTTPPSDITVTDGTSAVFTCDTSGAPKPA 586

  Fly   739 IVWKKATGSK---SGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQL 800
            |||:|  ||:   ||..:..|   || ||.:|.|.:..:.....|.|.|.|:|..|. :...:.|
Zfish   587 IVWRK--GSQVLASGSVQTPR---FT-LLESGGLQILPIMPSDAGNYTCLASNTEGL-VNATVAL 644

  Fly   801 KVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEATP 863
            .|.|..:.|:......|.||.||:|.||.:.|..:.:  .| :.|...|:.||..::|:|:
Zfish   645 TVLSRTFISTPPEDQRVIKGTTAVLHCAATHDPRVTVRYSW-KKGTKPLSVSTGGRVSMKE---- 704

  Fly   864 DGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAM--ISSRSVNIKW 926
                ..|||....:.|.|.|.||..:..|||.:..:|:|.|.|..|..|:.|:  ..||:|.:.|
Zfish   705 ----GSLQISQTWSGDIGDYTCRVISPAGNDSKSARLEVIELPHSPRNLQVALNETDSRTVLLSW 765

  Fly   927 QPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEG 991
            .....|...:..||:||.|  ::.|..:::|.      ..|...:.::..|.||..|.|||.|..
Zfish   766 VRPFDGNSPLLHYIIEFSE--NNSPWKVYMDD------VSPTLASLLVIGLTPARTYQFRVCAVN 822

  Fly   992 SAGR---SAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYNVGYKL 1053
            ..||   ||.:..|::|.||  |:.||.::.|...::..:::.|..|.....:|.::||.:.|:|
Zfish   823 QVGRGQYSAETNRLMLREEP--PSAPPKNIVASGRTNQSIMVQWQPPPEPQLNGVLRGYVLRYRL 885

  Fly  1054 S---------SSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAA 1109
            :         :..:...|:..:        |||::     :.:|.:.|.|:...|.|..|:....
Zfish   886 AGLPGEFQLKNITSAEINYCLI--------GELII-----WTQYEIQVAAYTGAGLGVYSQSATE 937

  Fly  1110 QTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESRK 1174
            .|::.||:.||:||...||:|.:::.:|.|||....||:.|||||:..|             ...
Zfish   938 YTLQGVPTAPPQDVEAVALNSTTIKFTWTPPPQQFINGINQGYKLLVWP-------------EHC 989

  Fly  1175 TTALTMV--------------LTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADI 1225
            ...:|||              ::.|||:|.|...||..|..|||..|......:..|.|.....:
Zfish   990 PDCITMVTIAPEFHGSRHYGYVSNLRKFTWYETAVLCFTTPGDGPASTSQLIQTHVDKPGPVTQL 1054

  Fly  1226 KVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNE---KRSLPSQQAYYEAKGLHPH 1287
            ........||.|||..|.:.||:||.|     |::.:|...||   .::|.:....|:..||...
Zfish  1055 SFTEILDTSLRISWQEPEDKNGIITGY-----VLSWQEAGQNETLVSQTLSNSTLAYKVTGLTSL 1114

  Fly  1288 MEYQFWVTASTRVGEGKSSRVSSQITTN------RIPARII----------------SFGGPVVR 1330
            ..|...|.|.|:.|.|.|:  ||.|:|.      ..|:.::                |.|...:.
Zfish  1115 TTYALQVAAVTQAGVGAST--SSTISTGLPPELPGAPSNLVISNISPRSVTIQFSPGSDGKTEIS 1177

  Fly  1331 PWRSTVTLPCTAVGKPKR--EWFKSDVALRQGGLHNSQLLDSGDLI--------ISSLQLADGGN 1385
            .|  .|......||:.::  ||   .|...:.....|..|:..:||        :..:.:.....
Zfish  1178 KW--IVEGQVVIVGEEEKEAEW---KVLYERDSPPASDTLEIPNLIPFTQYRFRMKQVNIVGSSP 1237

  Fly  1386 YSCQVDNGIGTDRLTHTLIVQVPPTAPV-LYVTSATSSSILMHW----KCGFTGNAPITGYTLFY 1445
            :|       .:.||..|| ...|..||. |.|.||:.:|:.:.|    :..:.||....||.:..
Zfish  1238 FS-------ESSRLMQTL-QSSPDVAPTELVVFSASETSLRIRWEPLPEAAYNGNPESVGYRVRA 1294

  Fly  1446 RRANG-NTDEMQLSRHASSHE--LKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSP-GHP 1506
            :||:| ....|:......|.|  ::||...:.|::.:.|.|.:|..|.|:.:..:|:...| |.|
Zfish  1295 QRADGFGQPRMETVSDRLSCEVTVEGLEEWTDYELSIQAFNSIGPGPWSSHVLGKTKESVPSGAP 1359

  Fly  1507 ASTALLAPNSTSLLVRLHSWPD---NGCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINN 1568
            .:.:..|.:|||:||...|.|:   ||..|.|.|| ||....|...:..||:.  .....:::.|
Zfish  1360 ENVSAEAMSSTSVLVTWGSVPEHQKNGHILGYKVL-YREKDSDRAPQAHLVNG--NQTHMLLLRN 1421

  Fly  1569 LQPSTLYQLRMEAHNVAGIS------QAEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLL 1627
            |...|:|::::.|....|..      .||     .|||..|.||                 :.|:
Zfish  1422 LSKFTVYEIQVLAFTRVGDGPPSLPPTAE-----RTKDDVPGPP-----------------VRLM 1464

  Fly  1628 IPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSM 1692
            .|.:...|        :.|.::      ||......|....:..|.
Zfish  1465 FPEVRLSS--------VRVVWQ------PPSEPNGIIMGYQISYRL------------------- 1496

  Fly  1693 QNNDKIPETSEDISPYATFQLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPPPAASKN 1757
                       ||:....|...|.|.|..|....|......:.|....|.| :|......|....
Zfish  1497 -----------DINDPNKFTTVEVGSNARQFTVTGLMPESAYVFQITARTL-QGWGPADEAIVIT 1549

  Fly  1758 RRRHSRKTEPESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHGAQSSTSSDLSPMSEQKSLPR 1822
            ..:..|...|.         :||..:       :|...:.:..|.......|  ||:
Zfish  1550 TEKRERPQAPR---------RLTVPQ-------KGVESYKLRLHWMAGGDGS--SPV-------- 1588

  Fly  1823 RGRSRYHHQQ--------YQFSTNTTPRHHNS----NKMNNNTTSNTNTTATN------------ 1863
                ||...|        ::..|::.| |:||    :::...|:......|||
Zfish  1589 ----RYFTLQTLELPDGDWKTHTSSIP-HNNSSWEVDRLKPYTSYKFRMMATNDVGDSAFSKETE 1648

  Fly  1864 --TT-------------ATPSTSSN------------SNKIL---------SPRGGNLKSISSTF 1892
              ||             ..|||:::            .|.||         .|...|.|.:.||.
Zfish  1649 PVTTLQDVPGEAPVILLVKPSTTTSVIVQWQPPAEGTVNGILVGYRVYYRELPSESNPKVVQSTN 1713

  Fly  1893 KSQDSIQCHIPT---LVKSPSISTQQQKQFHK----------------------------QQLQN 1926
            :|..|::....:   .|.|||::..:..|..|                            :...:
Zfish  1714 QSTISLEFRAKSTFKTVSSPSLTEFELTQLSKYRRYAIVMTAFNVVGESPSSAPVEVFVGEAAPS 1778

  Fly  1927 SSTNNSQHSSSNPNSSSLKQQQPLLITP-------KLHQLEANGQ 1964
            .:..|.|..|.:.|...::.|.|.:.|.       |:|..|.:.|
Zfish  1779 VAPQNIQVKSVSSNQLDVEWQPPPVETQNGNIQGYKIHYWEKDRQ 1823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	11/27 (41%)
		IGc2	344..407	CDD:197706	8/16 (50%)
		IG_like	432..517	CDD:214653	27/108 (25%)
		IGc2	436..507	CDD:197706	24/94 (26%)
		I-set	521..610	CDD:254352	27/98 (28%)
		IGc2	533..597	CDD:197706	19/71 (27%)
		Ig	630..699	CDD:143165	17/69 (25%)
		IG_like	714..802	CDD:214653	29/90 (32%)
		Ig	725..802	CDD:299845	26/79 (33%)
		Ig	823..894	CDD:143165	21/72 (29%)
		FN3	906..1006	CDD:238020	30/104 (29%)
		FN3	1013..1111	CDD:238020	20/106 (19%)
		FN3	1119..1209	CDD:238020	34/103 (33%)
		FN3	1219..1313	CDD:238020	29/96 (30%)
		Ig	1336..1402	CDD:143165	13/75 (17%)
		FN3	1409..1498	CDD:238020	26/96 (27%)
		FN3	1515..1588	CDD:238020	24/75 (32%)
sdk1b	XP_017211454.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910