DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam2 and lrit1a

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	601	Identity:	126/601 - (20%)
Similarity:	203/601 - (33%)	Gaps:	172/601 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 ARLNIYGLPYIRLIPKVTAVSGETLNL---KCPVAGYPIE--------EIHWERGGRELPDDIRQ 566
            ||..|...|.|.|:|  .:..|:|..|   |..:...|.|        |..|....
Zfish    40 ARSVICNDPEISLVP--ASFPGDTSKLRIEKTAIKRIPSEAFSYLSNLEFLWMSFN--------- 93

  Fly   567 RVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSAR------------------RSGEVTVIVPPK 613
                    .:|.:..:|..|:|:.......|:|..                  .:.:::.: |.:
Zfish    94 --------VLSSLNSDSFRGLYSLEELRLDGNSLSSFPWESLMDMPSLRLLDIHNNQLSSL-PSE 149

  Fly   614 LSPFQTNILQLNMGDRASLTCSVVKGDLPLTIN------------------WRKDGRPIDPTQ-- 658
            .:.:..||..|::.....||......:..|||.                  |..|.|..|..|
Zfish   150 AALYMKNITYLDLSSNNLLTVPAEVLNTWLTIKPTLGAESSKLILGLHDNPWLCDCRLYDLVQFQ 214

  Fly   659 ---HMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVE 720
               .:||..:|........|:|..         |..|.||:...|.      ||     |...|.
Zfish   215 KSPSLSVAFIDTRLRCADPESLSG---------VLFSDAELRRCQG------PR-----VHTAVA 259

  Fly   721 RNR-----HIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKED--- 777
            |.|     :::|.|...|||.|.:.|::|.|           :|.     ||::||::.||.
Zfish   260 RVRSAVGNNVLLRCGTVGVPIPELAWRRADG-----------KPL-----NGTVLLENSKEGIVW 308

  Fly   778 ----------RE-GFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTS---RSVMVKKGDTALLQCA 828
                      |: |.|:|:|.|..|:. ..||.|.:|.:|...:.:   :..:..|....:::.|
Zfish   309 SILSVPAVSYRDTGKYICKATNYAGSA-EAVISLIINDAPKMENPTLDPKPKLKSKKPNTMVKAA 372

  Fly   829 VSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGN 893
            .. :|.|......:.||.|..|.....:..........:|..::.|..|:..|......|||..|
Zfish   373 YQ-EKHIATYVSPTPKNGLPLSGTVSYTGPYPGMESDNAANSRMNTQTASPDGFLETNLSNLAAN 436

  Fly   894 DQQLVQLQVQEPPLPPSVLEAAMI---SSRSVNIKWQ-PKTLGTGDVTKYIVEFREADHSLPPAL 954
            ...|.|       .|..|:.:..:   :..:|.:.|: |....|...:.....|.|.|
Zfish   437 TSSLQQ-------DPDRVVRSVKVIGDTDYTVCLNWRAPTAKNTTAFSVLYAVFGERD------- 487

  Fly   955 FVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQE--LIVRTEPQRPAGPPLS 1017
                .::|.| .|.:...:||.|.|.|:|...|..:|    ..|.:|  :|..|:
Zfish   488 ----MRRINV-SPGNNRIVIEGLVPKTKYIACVCVKG----LIPKKEQCVIFSTD---------- 533

  Fly  1018 LSARPLSSTELLISWV 1033
             :|...:.|:.||:.|
Zfish   534 -AAASANGTQKLINVV 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	2/3 (67%)
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	18/117 (15%)
		IGc2	533..597	CDD:197706	12/74 (16%)
		Ig	630..699	CDD:143165	19/91 (21%)
		IG_like	714..802	CDD:214653	30/106 (28%)
		Ig	725..802	CDD:299845	26/90 (29%)
		Ig	823..894	CDD:143165	14/70 (20%)
		FN3	906..1006	CDD:238020	23/105 (22%)
		FN3	1013..1111	CDD:238020	5/21 (24%)
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378	5/22 (23%)
		LRR_8	63..119	CDD:290566	11/72 (15%)
		LRR_RI	<77..175	CDD:238064	15/115 (13%)
		leucine-rich repeat	85..108	CDD:275378	5/39 (13%)
		LRR_8	108..167	CDD:290566	6/59 (10%)
		leucine-rich repeat	109..132	CDD:275378	2/22 (9%)
		leucine-rich repeat	133..156	CDD:275378	1/23 (4%)
		leucine-rich repeat	157..170	CDD:275378	3/12 (25%)
		LRRCT	199..243	CDD:214507	11/52 (21%)
		I-set	252..343	CDD:254352	32/112 (29%)
		Ig	259..333	CDD:299845	24/89 (27%)
		fn3	448..515	CDD:278470	16/78 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900