DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	699	Identity:	170/699 - (24%)
Similarity:	254/699 - (36%)	Gaps:	158/699 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 DTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSN------ 466
            |||....:.:....|       .:||:..|....|.|... |.:..:.||.||..|...
Human    13 DTFSQGTQTRFSQEP-------ADQTVVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAW 69

  Fly   467 ------GRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRL 525
                  |....|||         ::.|:...:.|...|.|.|...|.| ...|:|.:...|....
Human    70 PRYRVVGSADAGQY---------NLEITDAELSDDASYECQATEAALR-SRRAKLTVLIPPEDTR 124

  Fly   526 I---PKVTAVSGETLNLKC-PVAGYPIEEIHWERGGRE----------LPDDIRQRVQPDGSLTI 576
            |   |.:...:|...||.| .....|...|.|.|.|.:          |.|..|:...  ..|.|
Human   125 IDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV--SQLLI 187

  Fly   577 SPVQKNSDSG-VYTCWARNKQGHSARRSG-EVTVIVPP----KLSPFQTNILQLNMGDRASLTCS 635
            :|.  :.|.| |:||.:.|:...|.:.:. |:.|..||    .:.| ||    :..|:|...||.
Human   188 NPT--DLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEP-QT----VQEGERVVFTCQ 245

  Fly   636 VVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQ 700
            .......|...|.|.|..|:.......:....|          |..|...||.|.|.......|.
Human   246 ATANPEILGYRWAKGGFLIEDAHESRYETNVDY----------SFFTEPVSCEVHNKVGSTNVST 300

  Fly   701 ALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERP------ 759
            .:.|:..||.:|:|.....:....:.|.|...|.|..::.|.|...:       :..||
Human   301 LVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSN-------MGPRPPGSPPE 358

  Fly   760 ---FTKLLGNGS-LLLQHVKEDREGFYLCQANNGIGTGIG---KVIQLKVNSSPYFSSTSRSVMV 817
               ..::|.|.: |||:.|.:...|.|.|:|   |...||   :.:.|.||..|..||.:....|
Human   359 AALSAQVLSNSNQLLLKSVTQADAGTYTCRA---IVPRIGVAEREVPLYVNGPPIISSEAVQYAV 420

  Fly   818 KKGDTALLQCAV-SGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTV-DATDS 880
             :||...::|.: |...|..|.|... :|.|...|..:.:|::..:..||.:.|.|..| :|...
Human   421 -RGDGGKVECFIGSTPPPDRIAWAWK-ENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQ 483

  Fly   881 GPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISS-------------------------- 919
            ..|.|.|.|.:|....::||:.:| .||..::..|.|.:
Human   484 THYNCTAWNSFGPGTAIIQLEERE-VLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDV 547

  Fly   920 --RSVNIK-----WQPKTL------GTGDVT------KYIVEFREADHSLPPAL---FVDQWQQI 962
              |.::||     .:|.|:      .|..|:      |.|....:.|..|...|   .:|..::.
Human   548 TLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEY 612

  Fly   963 EVKDPP--HFNAMIENLKPATR---YA-FRVIAEGSA---GRSAPSQEL 1002
            |:|||.  ::|......:|::|   || :|  |.|.|   ||  ||..|
Human   613 EMKDPTNGYYNVRAHEDRPSSRAVLYADYR--APGPARFDGR--PSSRL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	3/9 (33%)
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	24/96 (25%)
		IGc2	436..507	CDD:197706	18/82 (22%)
		I-set	521..610	CDD:254352	27/104 (26%)
		IGc2	533..597	CDD:197706	21/75 (28%)
		Ig	630..699	CDD:143165	14/68 (21%)
		IG_like	714..802	CDD:214653	23/100 (23%)
		Ig	725..802	CDD:299845	22/89 (25%)
		Ig	823..894	CDD:143165	20/72 (28%)
		FN3	906..1006	CDD:238020	35/154 (23%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	25/111 (23%)
		Ig	25..116	CDD:299845	25/108 (23%)
		Ig2_KIRREL3-like	138..219	CDD:143236	22/84 (26%)
		I-set	223..304	CDD:254352	21/95 (22%)
		Ig_2	227..305	CDD:290606	20/92 (22%)
		Ig_2	311..405	CDD:290606	24/103 (23%)
		IG_like	314..405	CDD:214653	23/100 (23%)
		Ig5_KIRREL3	407..504	CDD:143306	27/98 (28%)
		IG_like	416..504	CDD:214653	24/89 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810