DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and Cntn6

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_059079.2 Gene:Cntn6 / 53870 MGIID:1858223 Length:1028 Species:Mus musculus


Alignment Length:1234 Identity:297/1234 - (24%)
Similarity:458/1234 - (37%) Gaps:332/1234 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 CRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWFT 273
            |....|.:|.:.:..|        :.:|.|        :.:|:.| .:|.|.|.|.|||.|.| .
Mouse    17 CAGEGRFSRPIFIQEP--------QDVIFP--------LDLSRSE-IILTCTANGYPSPHYRW-K 63

  Fly   274 HNGAGPLPVLSGPRVRLLGPILAIEAV-TGEDSGVYKCTAGN-VGGEASAELRLTVA-------- 328
            .||. .:........||.|..|||.:. |.:|.|:|:|.|.| ||...|.:.:|..|        
Mouse    64 QNGT-DIDFGMTYHYRLDGGSLAISSPRTDQDIGIYQCLATNPVGTILSRKAKLQFAYIEDFETK 127

  Fly   329 --TPIQVEISPNVLSV-----HMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSGRVEDT-- 384
              :.:.|.....|:.:     |.|   |.....|.|.||:.:|     :|.|:..|    :||  
Mouse   128 TRSTVSVREGQGVVLLCGPPPHFG---ELSYAWTFNDSPLYVQ-----EDKRRFVS----QDTGN 180

  Fly   385 LVVPRVSRENRGMYQCVVRRPEGDTFQATAELQ-------------LGDAPPVLLYSFIEQTLQP 436
            |...:|...:.|.|.|.|...|     |...:|             :|:..|.:...|.| |:|.
Mouse   181 LYFAKVEPSDVGNYTCFVTNKE-----AHRSVQGPPTPLVLRTDGVMGEYEPKIEVRFPE-TIQA 239

  Fly   437 G--PAVSLKCSAAGNPTPQISW-TLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEY 498
            .  .::.|:|.|.|||.|.||| .|||.|:|...::...|.|         :.|.....||.|.|
Mouse   240 AKDSSIKLECFALGNPVPDISWKRLDGSPMPGKIKYSKSQAI---------LEIPKFQQEDEGFY 295

  Fly   499 ACIAENRAGRVQHAARLNIYGLP---------YIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWE 554
            .|||.|..||.....:|..|..|         |:.:.        ::|..:|..:|.|.....|.
Mouse   296 ECIAGNLRGRNLAKGQLIFYAPPEWEQKIQNTYLSIY--------DSLFWECKASGNPNPSYTWL 352

  Fly   555 RGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIV-PPKLSPFQ 618
            :.|:.|  :..:|:|.:....|..:...||||:|.|.|.||. .:...:.|:.|:. .|..|.  
Mouse   353 KNGQRL--NTEERIQIENGTLIITMLNISDSGIYQCAAENKY-QTIYANAELRVLASAPDFSK-- 412

  Fly   619 TNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTG 683
                                                :|.:.:||.||            |.|   
Mouse   413 ------------------------------------NPIKKISVVQV------------GGD--- 426

  Fly   684 NYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSK 748
                                                     |.:.|:....|..||.||:.|   
Mouse   427 -----------------------------------------ISIECKPNAFPKASISWKRGT--- 447

  Fly   749 SGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSR 813
                |.:::......|.:|||.:.:|.....|.|.|.|.|..|.|         .||.......|
Mouse   448 ----ENLKQSKRVLFLEDGSLKICNVTRADAGSYTCVATNQFGNG---------KSSGGLVVKER 499

  Fly   814 SVM--------VKKGDTALLQCAVSGDKPINI--VWMRSGKNTLNPSTNYKISVKQEATPDGVS- 867
            :::        |..|::.:|.|.||.|..:.:  ||..:|     ...:.|..|.......|.| 
Mouse   500 TIITVPPSKMDVTVGESIVLPCQVSHDPTMEVLFVWYFNG-----DIIDLKKGVAHFERIGGESV 559

  Fly   868 AELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLG 932
            .:|.||.:....||.|.|...........:..:.|:.||.||..::...|||.:..:.|:|    
Mouse   560 GDLMIRNIQLGHSGKYLCTVQTTLERLSAVADIIVRGPPGPPEDVKVEHISSTTSQLSWRP---- 620

  Fly   933 TGDVTKYIVEFREADHSLPPALFVDQ--------WQQI----EVKDPPHFNAMIENLKPATRYAF 985
                        ..|::.|..:|..|        ||.:    |:.:...:||.:..|.|...|.|
Mouse   621 ------------GPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGQTYNATVVGLSPWVEYEF 673

  Fly   986 RVIAEGSAGRSAPSQ--ELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGDIQGYN 1048
            ||:|..:.|...||:  ||: ||:...|...|.:::....|.:||:|:|.|...||::|:..||.
Mouse   674 RVVAGNNIGIGEPSKPSELL-RTKASVPNVAPGNINGGGGSRSELVITWEAIPEELQNGEGFGYI 737

  Fly  1049 VGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKF----------ARYTVVVQAFNQVGPGPL 1103
            |.::  ..|.||:....|:           |...:||          :.:.|.|..:|..|.|.|
Mouse   738 VMFR--PVGTTAWMKERVA-----------LVESSKFIYRNESIMPLSPFEVKVGVYNNEGEGSL 789

  Fly  1104 SEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIF------EPIIDD 1162
            |..|...:.||.|...|......:.|:..::|||.........|.:.||::::      |.:|..
Mouse   790 STVTIVYSGEDEPQLAPRGTSVQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDNSKESMIGK 854

  Fly  1163 IQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVP-EAPADIK 1226
            |:.|.:        ..|..:||||..|.|...|.|:...|.|..|.|:...:::..| :.||:|.
Mouse   855 IRVSGN--------VTTKNITGLRANTIYFASVRAYNTAGTGPSSLPVNVTTKKSPPSQPPANIA 911

  Fly  1227 VVSSSSQSLYISW--LPPNEPNGVITKYSLYTRVVNGRE------ELNNEKRSL--PSQQAYYEA 1281
            ...|:|: |.::|  :...|....:..|.:..|  ..|:      |.||....|  |.::     
Mouse   912 WKLSNSK-LCLNWEHVKTMENESEVLGYKILYR--QNRQSKTHILETNNTSAELLVPFEE----- 968

  Fly  1282 KGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIP--ARIISFGGPVVRPWRSTVTLPCTAV 1343
                   :|...:...:..|:|.|   |.:|   |||  :.:.|.|..:.:|  ||.:|....|
Mouse   969 -------DYLIEIRTVSDGGDGSS---SEEI---RIPKMSSLSSTGVQISKP--STQSLSMVGV 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352 31/90 (34%)
Ig 247..327 CDD:299845 30/81 (37%)
I-set 332..418 CDD:254352 24/105 (23%)
IGc2 344..407 CDD:197706 18/64 (28%)
IG_like 432..517 CDD:214653 31/87 (36%)
IGc2 436..507 CDD:197706 26/73 (36%)
I-set 521..610 CDD:254352 23/97 (24%)
IGc2 533..597 CDD:197706 19/63 (30%)
Ig 630..699 CDD:143165 7/68 (10%)
IG_like 714..802 CDD:214653 21/87 (24%)
Ig 725..802 CDD:299845 21/76 (28%)
Ig 823..894 CDD:143165 19/73 (26%)
FN3 906..1006 CDD:238020 29/113 (26%)
FN3 1013..1111 CDD:238020 28/107 (26%)
FN3 1119..1209 CDD:238020 24/95 (25%)
FN3 1219..1313 CDD:238020 22/104 (21%)
Ig 1336..1402 CDD:143165 2/8 (25%)
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
Cntn6NP_059079.2 Ig 26..120 CDD:416386 33/112 (29%)
Ig strand A 27..31 CDD:409353 0/3 (0%)
Ig strand A' 34..39 CDD:409353 2/12 (17%)
Ig strand B 45..53 CDD:409353 3/8 (38%)
Ig strand C 58..64 CDD:409353 3/6 (50%)
Ig strand C' 66..69 CDD:409353 1/3 (33%)
Ig strand D 76..80 CDD:409353 1/3 (33%)
Ig strand E 82..88 CDD:409353 3/5 (60%)
Ig strand F 95..104 CDD:409353 4/8 (50%)
Ig strand G 107..120 CDD:409353 3/12 (25%)
Ig 129..214 CDD:416386 24/101 (24%)
Ig strand A 130..135 CDD:409353 0/4 (0%)
Ig strand B 139..145 CDD:409353 1/5 (20%)
Ig strand C 153..159 CDD:409353 0/5 (0%)
Ig strand C' 164..166 CDD:409353 0/1 (0%)
Ig strand D 171..176 CDD:409353 2/8 (25%)
Ig strand E 179..183 CDD:409353 1/3 (33%)
Ig strand F 193..201 CDD:409353 3/7 (43%)
Ig strand G 203..214 CDD:409353 2/10 (20%)
Ig 227..315 CDD:416386 34/97 (35%)
Ig strand A 227..232 CDD:409353 1/4 (25%)
Ig strand A' 235..240 CDD:409353 3/5 (60%)
Ig strand B 243..252 CDD:409353 2/8 (25%)
Ig strand C 258..262 CDD:409353 2/3 (67%)
Ig strand C' 265..267 CDD:409353 1/1 (100%)
Ig strand D 276..279 CDD:409353 0/2 (0%)
Ig strand E 280..285 CDD:409353 1/13 (8%)
Ig strand F 293..301 CDD:409353 5/7 (71%)
Ig strand G 304..315 CDD:409353 3/10 (30%)
Ig 319..403 CDD:416386 21/94 (22%)
Ig strand A 319..322 CDD:409353 0/2 (0%)
Ig strand A' 326..330 CDD:409353 1/3 (33%)
Ig strand B 334..342 CDD:409353 2/7 (29%)
Ig strand C 348..353 CDD:409353 1/4 (25%)
Ig strand C' 355..358 CDD:409353 1/2 (50%)
Ig strand D 363..367 CDD:409353 2/3 (67%)
Ig strand E 369..374 CDD:409353 1/4 (25%)
Ig strand F 383..390 CDD:409353 3/6 (50%)
Ig strand G 394..403 CDD:409353 1/8 (13%)
Ig5_Contactin 408..496 CDD:409358 32/197 (16%)
Ig strand B 427..431 CDD:409358 1/3 (33%)
Ig strand C 440..444 CDD:409358 2/3 (67%)
Ig strand E 462..466 CDD:409358 3/3 (100%)
Ig strand F 476..481 CDD:409358 2/4 (50%)
Ig strand G 489..492 CDD:409358 1/2 (50%)
Ig 500..598 CDD:416386 22/102 (22%)
Ig strand A' 507..512 CDD:409353 0/4 (0%)
Ig strand B 515..523 CDD:409353 2/7 (29%)
Ig strand C 532..536 CDD:409353 1/3 (33%)
Ig strand E 560..564 CDD:409353 1/3 (33%)
Ig strand F 573..580 CDD:409353 3/6 (50%)
Ig strand G 587..591 CDD:409353 0/3 (0%)
FN3 598..691 CDD:238020 27/108 (25%)
FN3 703..796 CDD:238020 28/105 (27%)
FN3 805..898 CDD:238020 25/100 (25%)
FN3 903..983 CDD:214495 19/94 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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