DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and NTM

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001338930.1	Gene:	NTM / 50863	HGNCID:	17941	Length:	367	Species:	Homo sapiens

Alignment Length:	394	Identity:	95/394 - (24%)
Similarity:	150/394 - (38%)	Gaps:	84/394 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 TISPVQKNSDS-GVYTCWARNKQGHSAR--------RSGEVTVIVPPKLSPFQTNILQLNMGDRA 630
            ||.|...||.| .::|       |.:|.        |||:.|.       |...:.:.:..|:.|
Human     3 TIQPKMHNSISWAIFT-------GLAALCLFQGVPVRSGDATF-------PKAMDNVTVRQGESA 53

  Fly   631 SLTCSVVKGDLPLT-INW---------RKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNY 685
            :|.|::   |..:| :.|         ..|...:||...:......||:  :.|:|:.....|.|
Human    54 TLRCTI---DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS--IEIQNVDVYDEGPY 113

  Fly   686 SCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWK----KATG 746
            :|.|:.......:...|:|.|.|:.:....|.::....:|.|.|.|.|.|.|::.|:    ||.|
Human   114 TCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG 178

  Fly   747 SKS-GEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSS 810
            ..| .||.|:                |.:..::.|.|.|.|:|.:...:.:.:::.||..||.|.
Human   179 FVSEDEYLEI----------------QGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISE 227

  Fly   811 TSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTV 875
             ::...|..|....|||..|........|.:..|..:..    |..||.|..|  ..::|....|
Human   228 -AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG----KKGVKVENRP--FLSKLIFFNV 285

  Fly   876 DATDSGPYFCRASNLYGNDQQLVQL-QVQEPPL-----------------PPSVLEAAMISSRSV 922
            ...|.|.|.|.|||..|:....:.| ::.||..                 |.:|.|.:..:||..
Human   286 SEHDYGNYTCVASNKLGHTNASIMLFELNEPTSSTLLQEVKTTALTPWKGPGAVSEVSNGTSRRA 350

  Fly   923 NIKW 926
            ...|
Human   351 GCVW 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	13/43 (30%)
		IGc2	533..597	CDD:197706	7/22 (32%)
		Ig	630..699	CDD:143165	17/78 (22%)
		IG_like	714..802	CDD:214653	22/92 (24%)
		Ig	725..802	CDD:299845	21/81 (26%)
		Ig	823..894	CDD:143165	21/70 (30%)
		FN3	906..1006	CDD:238020	6/38 (16%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
NTM	NP_001338930.1	Ig	44..132	CDD:416386	19/92 (21%)
		Ig strand A'	44..49	CDD:409353	0/4 (0%)
		Ig strand B	51..59	CDD:409353	3/7 (43%)
		CDR1	59..63	CDD:409353	1/6 (17%)
		FR2	64..70	CDD:409353	2/5 (40%)
		Ig strand C	64..70	CDD:409353	2/5 (40%)
		CDR2	71..83	CDD:409353	1/11 (9%)
		Ig strand C'	72..76	CDD:409353	0/3 (0%)
		Ig strand C'	80..83	CDD:409353	1/2 (50%)
		FR3	84..118	CDD:409353	9/35 (26%)
		Ig strand D	87..94	CDD:409353	0/6 (0%)
		Ig strand E	97..103	CDD:409353	2/7 (29%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	0/3 (0%)
		Ig strand G	123..132	CDD:409353	1/8 (13%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	136..205	CDD:404760	22/84 (26%)
		Ig strand A'	142..147	CDD:409353	1/4 (25%)
		Ig strand B	153..160	CDD:409353	3/6 (50%)
		Ig strand C	166..171	CDD:409353	1/4 (25%)
		Ig strand D	177..180	CDD:409353	1/2 (50%)
		Ig strand E	184..190	CDD:409353	3/21 (14%)
		Ig strand F	197..204	CDD:409353	3/6 (50%)
		Ig strand G	211..219	CDD:409353	0/7 (0%)
		Ig_3	222..299	CDD:404760	23/83 (28%)
		putative Ig strand A	223..229	CDD:409353	3/6 (50%)
		Ig strand B	239..243	CDD:409353	1/3 (33%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810