DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam2 and negr1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	333	Identity:	83/333 - (24%)
Similarity:	131/333 - (39%)	Gaps:	54/333 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 VTAVSGETLNLKCPVAGYPIEEIH---W-------ERGGRELPDDIRQRV------QPDGSLTIS 577
            |.:..|:|..|:|    |.::.|.   |       ..|..:...|.|..:      :.:.||.|.
Zfish    47 VVSRQGDTALLRC----YLLDGISKGAWLNRSSIIYAGNDKWSGDPRVSIVSNVGDKHEYSLQIQ 107

  Fly   578 PVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLP 642
            .|.. :|.|||||..::::....:.. ::.|.||||:....::| .:|.|...||.|: ..|...
Zfish   108 KVDV-TDEGVYTCSIQSERNLHPKLI-QLIVKVPPKIYDISSDI-TVNEGSNVSLICA-ASGKPE 168

  Fly   643 LTINWRKDGRPIDPTQHMSVKQVDQYNS--ILVIENLGSDHTGNYSCVVRNSAAEVENSQA-LLV 704
            ..|:||          |:| ....:|.|  .|.|..:..|..|:|.|...|..|..:.... :.|
Zfish   169 PKISWR----------HIS-PSARKYESGEYLNITGISRDQAGDYECGAENDIASPDTKTVRVTV 222

  Fly   705 NVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSK---SGEYEEVRERPFTKLLGN 766
            |.||. |.|.....|...:..:|.|:|..||:|...|.|  |.|   .|:...:     ..|...
Zfish   223 NFPPA-IHEMKSHGVRPGQVALLRCEAAAVPSPVFEWYK--GEKRINMGQGIVI-----NNLSSR 279

  Fly   767 GSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSG 831
            ..|.::::.:||.|.|.|.|.|.:||.     ...|..:|....|:.|.:........:..:..|
Zfish   280 SVLTVKNMTQDRYGNYTCVAVNRLGTA-----NASVPLNPIIEPTTTSAVSSPASNPAMYGSTGG 339

  Fly   832 DKPINIVW 839
            .:.:...|
Zfish   340 AEVLLACW 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	22/96 (23%)
		IGc2	533..597	CDD:197706	20/79 (25%)
		Ig	630..699	CDD:143165	19/70 (27%)
		IG_like	714..802	CDD:214653	23/90 (26%)
		Ig	725..802	CDD:299845	22/79 (28%)
		Ig	823..894	CDD:143165	2/17 (12%)
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
negr1	XP_009300786.1	Ig	42..121	CDD:299845	21/78 (27%)
		IG_like	44..136	CDD:214653	21/94 (22%)
		I-set	140..222	CDD:254352	24/94 (26%)
		IGc2	153..208	CDD:197706	18/66 (27%)
		IG_like	236..312	CDD:214653	24/87 (28%)
		IGc2	238..304	CDD:197706	20/72 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900