DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and LSAMP

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_001305844.1 Gene:LSAMP / 4045 HGNCID:6705 Length:361 Species:Homo sapiens


Alignment Length:390 Identity:93/390 - (23%)
Similarity:149/390 - (38%) Gaps:105/390 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 PTRLRINS---HRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSG 285
            ||.|.:.|   :||         |.::.|.|.:.|:|.||.:. .:.:.:|...:|.    :.:|
Human    24 PTGLPVRSVDFNRG---------TDNITVRQGDTAILRCVVED-KNSKVAWLNRSGI----IFAG 74

  Fly   286 -------PRVRL-----LGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRLTVATPIQVEISPN 338
                   |||.|     |...|.|:.|...|.|.|.|:........::::.|.|..|.::....:
Human    75 HDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISS 139

  Fly   339 VLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSGR----VEDTLVVPRVSRENRGMYQ 399
            .::|:.|......|:......||    |.|    |.|..:||    .|:.|.:..::||..|.|:
Human   140 DVTVNEGSNVTLVCMANGRPEPV----ITW----RHLTPTGREFEGEEEYLEILGITREQSGKYE 196

  Fly   400 CVVRRPEGDTFQATAELQLGDA---------PPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQIS 455
            |          :|..|:...|.         ||.:..|...:. ..|...||||.|:..|.|...
Human   197 C----------KAANEVSSADVKQVKVTVNYPPTITESKSNEA-TTGRQASLKCEASAVPAPDFE 250

  Fly   456 WTLDGFPLPS-NG---RFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLN 516
            |..|...:.| ||   :...||         |.:.:::|..|..|.|.|:|.|:.|         
Human   251 WYRDDTRINSANGLEIKSTEGQ---------SSLTVTNVTEEHYGNYTCVAANKLG--------- 297

  Fly   517 IYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEI----HWERGGRELPDDIRQRVQPDGSLTIS 577
                        ||..|........|...:||:||    |:::.|   |..:|   ..:||::::
Human   298 ------------VTNASLVLFKRVLPTIPHPIQEIGTTVHFKQKG---PGSVR---GINGSISLA 344

  Fly   578  577
            Human   345  344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352 23/100 (23%)
Ig 247..327 CDD:299845 22/91 (24%)
I-set 332..418 CDD:254352 20/89 (22%)
IGc2 344..407 CDD:197706 17/66 (26%)
IG_like 432..517 CDD:214653 24/88 (27%)
IGc2 436..507 CDD:197706 23/74 (31%)
I-set 521..610 CDD:254352 14/61 (23%)
IGc2 533..597 CDD:197706 12/49 (24%)
Ig 630..699 CDD:143165
IG_like 714..802 CDD:214653
Ig 725..802 CDD:299845
Ig 823..894 CDD:143165
FN3 906..1006 CDD:238020
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
LSAMPNP_001305844.1 Ig 38..128 CDD:386229 23/94 (24%)
Ig 132..215 CDD:386229 21/100 (21%)
Ig_3 219..294 CDD:372822 24/84 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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