DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam2 and IGLON5

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_001094842.1 Gene:IGLON5 / 402665 HGNCID:34550 Length:336 Species:Homo sapiens


Alignment Length:312 Identity:77/312 - (24%)
Similarity:127/312 - (40%) Gaps:49/312 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   627 GDRASLTCSVVKGDLPLT-INW---------RKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDH 681
            ||.|:|:|.:   |..:| :.|         ..|....||...:.:...::: |||:.| :|...
Human    47 GDNATLSCFI---DEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEF-SILITE-VGLGD 106

  Fly   682 TGNYSCVVRNSAAEVENSQALLVNVPPRW--IVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKA 744
            .|.|:|..:...........|:|:||.|.  |..||..|...|  :.|.|.|.|.|.|::.|::.
Human   107 EGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGN--VNLLCLAVGRPEPTVTWRQL 169

  Fly   745 TGSKSGEYEEVRERPFTKLLGNGSLL-LQHVKEDREGFYLCQANNGIGTG-IGKVIQLKVNSSPY 807
            ....:.|               |.:| :..::..:.|.|.|..:||:.:. ..:.:.:.||..|.
Human   170 RDGFTSE---------------GEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPT 219

  Fly   808 FSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQI 872
            .:..: |.....|..|||:|......|.:..|.:..: .|:..|...:.|:.|.|    .:.|..
Human   220 ITDVT-SARTALGRAALLRCEAMAVPPADFQWYKDDR-LLSSGTAEGLKVQTERT----RSMLLF 278

  Fly   873 RTVDATDSGPYFCRASNLYGNDQQLVQL-----QVQEPPLPPSVLEAAMISS 919
            ..|.|...|.|.|||:|..|.....::|     .....|.||.:|  |::|:
Human   279 ANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLL--ALLSA 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352
Ig 247..327 CDD:299845
I-set 332..418 CDD:254352
IGc2 344..407 CDD:197706
IG_like 432..517 CDD:214653
IGc2 436..507 CDD:197706
I-set 521..610 CDD:254352
IGc2 533..597 CDD:197706
Ig 630..699 CDD:143165 17/78 (22%)
IG_like 714..802 CDD:214653 19/89 (21%)
Ig 725..802 CDD:299845 15/78 (19%)
Ig 823..894 CDD:143165 21/70 (30%)
FN3 906..1006 CDD:238020 6/14 (43%)
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
IGLON5NP_001094842.1 Ig 41..129 CDD:416386 20/86 (23%)
Ig strand A' 41..46 CDD:409353
Ig strand B 48..56 CDD:409353 4/7 (57%)
CDR1 56..60 CDD:409353 1/6 (17%)
FR2 61..68 CDD:409353 2/6 (33%)
Ig strand C 61..67 CDD:409353 2/5 (40%)
CDR2 69..79 CDD:409353 1/9 (11%)
Ig strand C' 71..74 CDD:409353 0/2 (0%)
Ig strand C' 76..79 CDD:409353 1/2 (50%)
FR3 80..115 CDD:409353 10/36 (28%)
Ig strand D 84..91 CDD:409353 0/6 (0%)
Ig strand E 94..100 CDD:409353 3/6 (50%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 0/3 (0%)
Ig strand G 120..129 CDD:409353 1/8 (13%)
FR4 122..129 CDD:409353 1/6 (17%)
Ig_3 134..199 CDD:404760 19/81 (23%)
Ig strand B 148..157 CDD:409353 3/10 (30%)
Ig strand C 162..170 CDD:409353 2/7 (29%)
Ig strand F 191..199 CDD:409353 3/7 (43%)
Ig strand G 202..212 CDD:409353 0/9 (0%)
Ig_3 217..295 CDD:404760 22/83 (27%)
putative Ig strand A 218..224 CDD:409353 1/5 (20%)
Ig strand B 234..238 CDD:409353 3/3 (100%)
Ig strand C 247..251 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 1/3 (33%)
Ig strand F 288..293 CDD:409353 2/4 (50%)
Ig strand G 301..304 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.