DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and dscamb

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	2107	Identity:	638/2107 - (30%)
Similarity:	1002/2107 - (47%)	Gaps:	226/2107 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65
            |||    ...|.|.::.|...|...:.|.   ||......|.||:::|..:.|.|:..|..|:.|
Zfish     1 MWI----LAFLFLQSILNVFGEDLRSSLY---FVNASLQEVVFSSTTGALVPCPAAAVPPATLRW 58

  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130
            ..|.|..:.::.|:|.|..||||.:..|..:::...:::..|.|.|.|..|:|.|:|:.::||..
Zfish    59 YLATGEEIYDVPGIRHVHPNGTLQIYGFLPSSFSNLINDNTYYCTAENPSGKIRSQDLHIKAVFR 123

  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195
            :.|.|.|......||.||:.:|::|..|:|.|.||||..:..     ||....::.:..||.|.|
Zfish   124 EPYTVRVADQRVMRGNTAVFKCIIPASVEEYVSVVSWEKDTV-----SLVSGSRYLITSTGALYI 183

  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCV 260
            .::|..|....:||.:.||.|.:...|:..||.: |.....:|.:::.....:|.......|.|.
Zfish   184 LDVQSEDAVNIYRCTTRHRYTGETRQSNSARLLL-SEPVDSAPVILDGFERKEVMVGHRVELPCK 247

  Fly   261 AQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRL 325
            |.|.|.|.|.|...|.    |:.|..|.......|.|||....|:|.|.|...|..|.|....||
Zfish   248 ASGHPPPRYRWLRDNS----PLESDSRYHQSVSGLLIEATRPSDAGSYVCEVWNSFGNAKVVGRL 308

  Fly   326 TVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKD------GRQLPSSGRVEDT 384
            .|..|::..:||..:...:|......|.||.:..    .:|.||::      |..:..:|...:.
Zfish   309 VVKQPLKAVVSPRKVRGSVGSQVSLFCSVTGSDE----FDITWYRNAEKIYQGINVRITGINNEN 369

  Fly   385 LVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGN 449
            ||:..:::.:.|.|||..|..:..| |...::.|.|..|.:|.:|.|:.:.|...:||.|...|.
Zfish   370 LVMEGMAKSDGGAYQCFARNGKMST-QDLVQVVLEDGTPKILSAFSEKVVSPNEPISLVCHVKGT 433

  Fly   450 PTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAAR 514
            |.|.::||||..|:..:....:.:.||..|.|:|::|:||..|.|||.|.|...|.||.|.:.||
Zfish   434 PLPTVTWTLDDDPVIKDSNHRMDRIITTEGHVLSYLNVSHTQVSDGGVYRCTCNNSAGSVSYQAR 498

  Fly   515 LNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRV-QPDGSLTISP 578
            :|:.|...||.:..|||::|....:.|.:.|||...|.|.:....||.:.|||. :.:|:|.:|.
Zfish   499 INVRGPASIRPMKNVTAIAGRDTYIHCRIIGYPYYSIKWYKDSNLLPFNHRQRAFENNGTLKLSN 563

  Fly   579 VQKNSDSGVYTCWA---RNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGD 640
            || |||.|.|||:.   ..||.|   ||..|||.|||.:.  .::....::|.|..:.|.|:.||
Zfish   564 VQ-NSDEGEYTCYVLVDPEKQIH---RSVHVTVKVPPLIQ--HSDSQSASIGQRVFIPCVVISGD 622

  Fly   641 LPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVN 705
            ||::|.|.||||||:.:..:::..:| :.|.|.|.||...|.|:|:|:.||.||.||:|..|:|.
Zfish   623 LPMSITWHKDGRPINASLGVTIDNID-FTSSLRISNLSEIHNGSYTCIARNEAAAVEHSIQLIVK 686

  Fly   706 VPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEV--RERPFTKLLGNGS 768
            |||.:.|:|.|.:....:.:.|:|.|:|.|.|:|||..:.|:...:::.:  ......:||.|||
Zfish   687 VPPHFEVQPKDQDGIYGKSVTLNCSAKGNPIPTIVWNHSKGAGVPQFQPIALNSGSRVQLLENGS 751

  Fly   769 LLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDK 833
            ||::||.|:..|||||:.:|.:|..|.|.:.|.|......:|...:...::|....:.|...|:|
Zfish   752 LLIKHVLEEDAGFYLCKVSNDVGADISKSMYLTVKIPAMITSYPNTTRAEQGHMTEMSCTAHGEK 816

  Fly   834 PINIVWMRSGKNTLNPS-TNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQL 897
            ||.:.|.:. .:.:||. :.|.::||:  ..|.|.:.|||......|||.:.|.|.|.||.|:.:
Zfish   817 PIKVRWEKE-SHIINPDMSRYVVTVKE--VGDEVISTLQILHTVREDSGFFSCIAINSYGEDKGI 878

  Fly   898 VQLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQI 962
            :||.||:.|.||.| |...:..|::.::|.....|...:|.|.:.::....|         |...
Zfish   879 IQLIVQDRPDPPEV-EIREVKDRTIALRWTMGFDGNSPITGYDINYKNKSAS---------WASS 933

  Fly   963 EV-KD-PPHFN-AMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLS 1024
            :: || .|..| |.|..|.||:.|..|:.|:...|.|.||.||.:.|:...|.|.|..:....:|
Zfish   934 QMTKDVSPQLNQATIIELHPASTYNIRMFAKNQIGESRPSNELTITTDEAPPDGAPQDVQLEAIS 998

  Fly  1025 STELLISWVAPLPELRHGDIQGYNVGYK-LSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARY 1088
            |..:.::|..|...|::|.|:.|.|.|: ..:.|:..||..:|...||  ...|.|..|.|:.:|
Zfish   999 SQGIKVTWKPPHKHLQNGLIRSYQVCYREFGTGGSPQYNTINVDTTGD--IETLTLDNLKKYTQY 1061

  Fly  1089 TVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYK 1153
            .|.|||.|:.|.||.||.....|:|||||||||:|...|.:.:::.:||...|....||:|.||:
Zfish  1062 EVRVQAANRAGMGPTSEEITITTLEDVPSRPPENVVTTATTPETISLSWSALPKEALNGMLLGYR 1126

  Fly  1154 LIFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDV 1218
            :||...:.|  ....|:.:..||..::.|..|.|||||||||||.||.||||.|:.::..::|||
Zfish  1127 VIFWANLPD--GELGEIRNITTTKPSLELERLEKYTNYSIQVLAFTRAGDGVRSEQIYTRTKEDV 1189

  Fly  1219 PEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYY-EAK 1282
            |..||.:|..:|:|..:::|||||::.||:|.||.::..  |....:.:|..:.|  ..|: ...
Zfish  1190 PGPPAGVKAAASTSSVVFVSWLPPHKLNGIIRKYIVFCS--NPYPTVISEFEAAP--DVYFRRLT 1250

  Fly  1283 GLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPK 1347
            .|:.:.:|..||.|.|..|.|.:|.:.:.....:.||||::|.|.|..||...:.|||.|||.|.
Zfish  1251 NLNQNWQYSIWVVAVTAAGRGNTSEIITVEPQAKAPARILTFSGTVTTPWMRDIVLPCKAVGDPP 1315

  Fly  1348 R--EWFKSD------VAL-RQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTL 1403
            .  :|.|.:      |:: .:...||     :|..:|.:::..|.|.|.|...|..|:|.:...|
Zfish  1316 PTIKWLKGNNGTPAPVSIDGRRSAHN-----NGSFVIRTVKAEDSGYYRCVASNNWGSDEIMLNL 1375

  Fly  1404 IVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDE---MQLSRHASSHE 1465
            .|||||..|.|.||..|::||.:.|..|..|.:.|.||.|.|  :..|::|   ..:|....|:.
Zfish  1376 QVQVPPDQPRLTVTKTTTTSITLFWIPGDNGGSSIRGYILQY--SEDNSEEWGSYSISPSERSYR 1438

  Fly  1466 LKGLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLLVRLHSWPDN 1529
            |:.|.||:.|:..|:|||.||....|.|:..:|.|:.|.......|.:. |||.:.:.|..|.:.
Zfish  1439 LENLKCGTWYKFTLTAQNAVGPGRISEIIEAKTHGKEPQFAKDHELFSSINSTRVELNLIGWNNG 1503

  Fly  1530 GCPLLYFVLQYRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNF 1594
            |||:..|.|:||.|   ...:|.:|......:..| :.:||.:|.|:|:|...|.||.::....|
Zfish  1504 GCPIDSFTLEYRPV---DTTKWTMVKRDSLTKSHI-LYDLQEATWYELQMRVGNSAGTAEKRVLF 1564

  Fly  1595 VTLTKDGD---PPPPEI--MHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRH---- 1650
            .||..||.   |.|..:  ....|.|.     ..:.::: ||..:....|.:.::::..|.
Zfish  1565 ATLNMDGSTIAPLPKSVDPSQENRQGN-----EGLKMMV-TIICILVAICMVFIVLLVLRRRRRE 1623

  Fly  1651 ----MLKNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETSEDISPYATF 1711
                .|::|..|||....:.....:..|.: .|..|.:..|.:..:...::  :|.|.|...:|.
Zfish  1624 QRLKRLRDAKSLAEMLMSKNARTPDTVNKQ-QQTLRMHIDIPRAQLLIEER--DTMETIDDRSTV 1685

  Fly  1712 QLSEAG-GNMSQPHHGGPANTLLHSFMYHERALAEG----CSSPPPAASKNRRRHSRKTEPESEE 1771
            .|::.. |..|:.    .::|:.|:..|...:.|.|    .|...|..:...|| :.|..|.:..
Zfish  1686 LLTDNDFGETSKQ----KSSTVTHTVHYQSLSQATGPLVDVSDARPGTNPTARR-TAKAGPATRS 1745

  Fly  1772 SESDQ------------------------------DQLTSSRTESSNQHEGKIKHSIIYHGAQSS 1806
            ..:.|                              |:.:.|.:.|.:|...:.:.|::...:.||
Zfish  1746 RYASQWTLNRPHPPVSSHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASS 1810

  Fly  1807 TSSDLSPMSEQKSLPRRGRSRYHHQQYQ----FSTNTTPRHHNSNKMNNNTTSNTNTTATNT--- 1864
            |..:|:...|...:..:.|    |.::.    |.::|:.....:. .|:.|.|.|::|.:.:
Zfish  1811 TYEELARAYEHAKMEEQLR----HAKFTITECFISDTSSEQMTAG-TNDYTDSLTSSTPSESGIC 1870

  Fly  1865 --TATPSTSSNSNKILS---PR----GGNL--------------KSISSTFKSQDSIQCHIP--- 1903
              ||:|....:::::::   |:    .|.|              :..:|:.:......|..|
Zfish  1871 RFTASPPKPQDASRVMNMAVPKAHRPAGELVHLPPYLRMDFLLNRGAASSGREATGQTCMDPQKS 1935

  Fly  1904 TLVKSPSISTQQQKQFHKQQLQNSSTNNSQHSSSNPNS------------SSLKQQQP--LLITP 1954
            .:.|.|::.....          |.|.:|..|||.|.|            |:|.|::|  |....
Zfish  1936 RITKRPALLAPTP----------SETPSSALSSSGPPSREAVQQWQPGTASTLPQREPGDLAQAA 1990

  Fly  1955 KLHQLEANGQELLGLDGIG-----NSP 1976
            ||    ::.||.| ||..|     |:|
Zfish  1991 KL----SSSQESL-LDSRGHLKQSNNP 2012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	23/75 (31%)
		Ig	138..>203	CDD:299845	20/64 (31%)
		I-set	238..327	CDD:254352	27/88 (31%)
		Ig	247..327	CDD:299845	26/79 (33%)
		I-set	332..418	CDD:254352	20/91 (22%)
		IGc2	344..407	CDD:197706	16/68 (24%)
		IG_like	432..517	CDD:214653	32/84 (38%)
		IGc2	436..507	CDD:197706	27/70 (39%)
		I-set	521..610	CDD:254352	37/92 (40%)
		IGc2	533..597	CDD:197706	25/67 (37%)
		Ig	630..699	CDD:143165	30/68 (44%)
		IG_like	714..802	CDD:214653	32/89 (36%)
		Ig	725..802	CDD:299845	30/78 (38%)
		Ig	823..894	CDD:143165	24/71 (34%)
		FN3	906..1006	CDD:238020	30/102 (29%)
		FN3	1013..1111	CDD:238020	33/98 (34%)
		FN3	1119..1209	CDD:238020	39/89 (44%)
		FN3	1219..1313	CDD:238020	29/94 (31%)
		Ig	1336..1402	CDD:143165	21/74 (28%)
		FN3	1409..1498	CDD:238020	33/91 (36%)
		FN3	1515..1588	CDD:238020	25/72 (35%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352	22/70 (31%)
		I-set	225..310	CDD:254352	27/88 (31%)
		IGc2	239..300	CDD:197706	21/64 (33%)
		IG_like	320..400	CDD:214653	19/84 (23%)
		IGc2	328..391	CDD:197706	16/66 (24%)
		IG_like	417..501	CDD:214653	32/83 (39%)
		Ig	424..498	CDD:143165	29/73 (40%)
		IG_like	511..592	CDD:214653	33/84 (39%)
		IGc2	518..576	CDD:197706	24/58 (41%)
		I-set	595..685	CDD:254352	36/92 (39%)
		Ig	612..682	CDD:143165	31/70 (44%)
		I-set	689..785	CDD:254352	34/95 (36%)
		Ig7_DSCAM	706..785	CDD:143211	30/78 (38%)
		IG_like	795..883	CDD:214653	28/90 (31%)
		Ig	803..890	CDD:299845	31/89 (35%)
		FN3	887..980	CDD:238020	30/102 (29%)
		FN3	987..1084	CDD:238020	33/98 (34%)
		FN3	1092..1185	CDD:238020	39/94 (41%)
		FN3	1190..1279	CDD:238020	29/92 (32%)
		IGc2	1302..1367	CDD:197706	19/69 (28%)
		FN3	1398..1471	CDD:238020	25/74 (34%)
		FN3	1485..1557	CDD:238020	24/75 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4915
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	917	1.000	Inparanoid score	I353
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6394
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840