DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and PTPRQ

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	XP_016874762.1	Gene:	PTPRQ / 374462	HGNCID:	9679	Length:	2536	Species:	Homo sapiens

Alignment Length:	1699	Identity:	351/1699 - (20%)
Similarity:	577/1699 - (33%)	Gaps:	539/1699 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 QPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYI-----------TVHGDVISHVNIS 488
            :|||.|.|.....|:....:||..   |...|||.:  .||           ||:..|.|..:..
Human   277 KPGPPVFLAGERVGSAGILLSWNT---PPNPNGRII--SYIVKYKEVCPWMQTVYTQVRSKPDSL 336

  Fly   489 HVMVED---GGEY--ACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPI 548
            .|::.:   |..|  ...|||.||       :.::..|:  |.....:..|:.:||.........
Human   337 EVLLTNLNPGTTYEIKVAAENSAG-------IGVFSDPF--LFQTAESAPGKVVNLTVEAYNASA 392

  Fly   549 EEIHWERGGRELPDDIRQRVQPDGSLT-----------------------------ISPVQKNSD 584
            .::.|     .||.      ||:|.:|                             :....:||:
Human   393 VKLIW-----YLPR------QPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSE 446

  Fly   585 S------------GVYTCWARNKQGHSARRSGEVTVI-------VPPKLSPFQTNILQLNMGDRA 630
            |            |..|..:|.....|.....|::.:       |...|.|:.|.:.:::
Human   447 SFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVS----- 506

  Fly   631 SLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVR---NS 692
              ..:...|.:..||....:..|..|.|:.....:.. .|..::.:..:..||.:|..|.   .|
Human   507 --AATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITG-KSFSILWDPPTIVTGKFSYRVELYGPS 568

  Fly   693 AAEVENS----QALLVNVPP-----RWIVEPVDANVERNRHIMLHCQAQGVPTP----------- 737
            ...::||    :....|:.|     .:|.....|......:|       .|.||
Human   569 GRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNI-------SVFTPPDVPGAVFDLQ 626

  Fly   738 ---------SIVWKKATGSKSGEYEEVRERPF----------TKLLGNGSLL-------LQHVKE 776
                     .|.|||.. ..:|...:.|.:..          |.|.||...:       :.::.|
Human   627 LAEVESTQVRITWKKPR-QPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVE 690

  Fly   777 DREGFYLCQANNGIGTGIGKVIQLKVNSSP--YFSSTSR-----SVMVKKGDTALLQCAVSGDKP 834
            ...|.|  :.:..:.:.:..:.....||.|  .|.:.:|     |.:|...:..:...|.   :.
Human   691 PMVGLY--EGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAA---EQ 750

  Fly   835 INIVWMRSGKNTLNPSTNYKISVKQ-EATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLV 898
            ::.|..|     |.|.|.:.|||.. ....:|....|.:||
Human   751 LSYVIRR-----LVPFTEHMISVSAFTIMGEGPPTVLSVRT------------------------ 786

  Fly   899 QLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIE 963
               .|:.|....::....|||.|:.:.|.|.....|.:|.|.:...|.|        .::..||.
Human   787 ---RQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELD--------TNRAFQIT 840

  Fly   964 VKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQE--LIVRTEPQRPAGPPLSLSARPLSST 1026
            ..|.   :.:|..||..|:|..||.|....|.|:.|:|  :.|||....|...|..:....:::.
Human   841 TIDN---SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTAD 902

  Fly  1027 ELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVV 1091
            |:.:.| :| ||..:|.|..|.|.||   :.:|.|...:.:.|       ::|..|.....|.:.
Human   903 EIRLKW-SP-PEKPNGIIIAYEVLYK---NIDTLYMKNTSTTD-------IILRNLRPHTLYNIS 955

  Fly  1092 VQAFNQVGPG-PLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLI 1155
            |:::.:.|.| .:|...:.:|.|.||...||::....:||..:::|:.||.  ..||::|.|.:.
Human   956 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPS--SPNGIIQKYTIY 1018

  Fly  1156 FEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPE 1220
            .:      :.:.:|..:..||:||..:..|:|||.|.|:|.|.|..|:||.|.|:...:|||.|:
Human  1019 LK------RSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD 1077

  Fly  1221 A-PADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGL 1284
            : |.|..|...|..::.:||.||.||||:|..|::|....:..:.:|..:.||       |...|
Human  1078 SPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSL-------ELSDL 1135

  Fly  1285 HPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKRE 1349
            ..::||..:||||||.|:||:.            :.||||
Human  1136 DYNVEYSAYVTASTRFGDGKTR------------SNIISF------------------------- 1163

  Fly  1350 WFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPVL 1414
                                                   |...|..:|          ||..  :
Human  1164 ---------------------------------------QTPEGAPSD----------PPKD--V 1177

  Fly  1415 YVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCG------- 1472
            |..:.:||||::.|......|..|..|:::||..:| |.....:.|..:::...:...
Human  1178 YYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSG-TFMQNFTLHEVTNDFDNMTVSTIIDKLT 1241

  Fly  1473 --STYQIHLSAQNKVGT-SPTSTILHVRTQGQSP-GHPASTALLAPNSTSLLVRLHSW----PDN 1529
              |.|...|:|...||. :.:|.|:.|.|....| |...:....:.:||::.|   ||    ..|
Human  1242 IFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINV---SWVPPAQPN 1303

  Fly  1530 GCPLLY--FVLQYRAVTDDPDAEWVLVSNALKP-----QRRIVINNLQPSTLYQLRMEAHNVAGI 1587
            |....|  .:||.             ....::|     :|.|..:||:..|.|.|::......|.
Human  1304 GLVFYYVSLILQQ-------------TPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGF 1355

  Fly  1588 SQAEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHML 1652
            |......:.:..:.|.|           :|:          |.|.....:..|.:        :|
Human  1356 SDTYTAQLYIKTEEDVP-----------ETS----------PIINTFKNLSSTSV--------LL 1391

  Fly  1653 KNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETS------EDISPYATF 1711
            ...||:.....|....|..:..:|      .|:.|             ||      |::||:..:
Human  1392 SWDPPVKPNGAIISYDLTLQGPNE------NYSFI-------------TSDNYIILEELSPFTLY 1437

  Fly  1712 QLSEAGGNMSQPHHG-GPANTLLHSFMYHERA--LAE-------GCS--------SPPPAASKNR 1758
            ....|    ::...| ||::.|   |.|.:.:  ||.       .|:        ||.|......
Human  1438 SFFAA----ARTRKGLGPSSIL---FFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIV 1495

  Fly  1759 RRHSRKTEPESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHGAQSSTSSD-----LSPMSEQK 1818
            :.:|.|.    .|.|:|                      .||:...|...::     |.|:|
Human  1496 KVYSFKI----HEHETD----------------------TIYYKNISGFKTEAKLVGLEPVS--- 1531

  Fly  1819 SLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNN-----------NTTSNTNTTATN--------- 1863
                         .|....:...:..|.|:.:|           :...|....||:
Human  1532 -------------TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWD 1583

  Fly  1864 ---------TTATPSTSSNSNKILSPRGGN------LKSISSTFKSQ--------DSIQCHIPTL 1905
                     |....:...||.|: ||:...      |.:.|..||.:        |...||:.||
Human  1584 PPKKANGIITQYMVTVERNSTKV-SPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTL 1647

  Fly  1906 VKS-PSIST 1913
            .:: ||:.|
Human  1648 PETVPSVPT 1656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	26/97 (27%)
		IGc2	436..507	CDD:197706	24/86 (28%)
		I-set	521..610	CDD:254352	20/136 (15%)
		IGc2	533..597	CDD:197706	16/104 (15%)
		Ig	630..699	CDD:143165	12/71 (17%)
		IG_like	714..802	CDD:214653	18/124 (15%)
		Ig	725..802	CDD:299845	17/113 (15%)
		Ig	823..894	CDD:143165	13/71 (18%)
		FN3	906..1006	CDD:238020	28/101 (28%)
		FN3	1013..1111	CDD:238020	22/98 (22%)
		FN3	1119..1209	CDD:238020	29/89 (33%)
		FN3	1219..1313	CDD:238020	32/94 (34%)
		Ig	1336..1402	CDD:143165	3/65 (5%)
		FN3	1409..1498	CDD:238020	24/98 (24%)
		FN3	1515..1588	CDD:238020	19/83 (23%)
PTPRQ	XP_016874762.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910