DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and IL1R1

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_000868.1 Gene:IL1R1 / 3554 HGNCID:5993 Length:569 Species:Homo sapiens


Alignment Length:749 Identity:143/749 - (19%)
Similarity:237/749 - (31%) Gaps:277/749 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 LLIHNLQESDESQSFRCRSMHRLTRQVVVSS-------PTRLRINSHRGIISPSVVEHTAHVQVS 250
            |||.:| |:|     :|:  .|..:.::|||       |..|..|.|:|.|              
Human    13 LLISSL-EAD-----KCK--EREEKIILVSSANEIDVRPCPLNPNEHKGTI-------------- 55

  Fly   251 QDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNV 315
                               :|:..:...|:......|:......|.......||||.|.|...| 
Human    56 -------------------TWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRN- 100

  Fly   316 GGEASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPV------------GMQNILW 368
               :|..||:.::... ||..|| |..:.....:.:..|..:|..|            .:..:.|
Human   101 ---SSYCLRIKISAKF-VENEPN-LCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQW 160

  Fly   369 YKDGRQL-----PSSGRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYS 428
            |||.:.|     ..|| |:|.|:|..|:.::||.|.|                            
Human   161 YKDCKPLLLDNIHFSG-VKDRLIVMNVAEKHRGNYTC---------------------------- 196

  Fly   429 FIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVE 493
                                    ..|:|..|...|                      |:.|:  
Human   197 ------------------------HASYTYLGKQYP----------------------ITRVI-- 213

  Fly   494 DGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGET--------LNLKCPVAGYPIEE 550
               |:..:.||:..|                  |.:.:.:.||        :.|.|.|.|...:.
Human   214 ---EFITLEENKPTR------------------PVIVSPANETMEVDLGSQIQLICNVTGQLSDI 257

  Fly   551 IHWERGGRELPDD---------------IRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSA 600
            .:|:..|..:.:|               .::|......|.||.::.......:||:|:|..|..|
Human   258 AYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDA 322

  Fly   601 RRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSV-----VKGDLPLTINWRKDG-RPIDPTQH 659
               ..:.:|.|  ::.||.:::.:.:.....:.|||     .|.|:.|   |.:|. ....|.:.
Human   323 ---AYIQLIYP--VTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVL---WYRDSCYDFLPIKA 379

  Fly   660 MSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQA---LLV----NVPPRWIVEPVDA 717
            ...|..|.|  ||..:.:|...|.:....|.....||...|.   |.:    :.....|||.::.
Human   380 SDGKTYDAY--ILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINE 442

  Fly   718 NVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFY 782
            ||:::|.:::..                         |||......||..|       |::...|
Human   443 NVKKSRRLIIIL-------------------------VRETSGFSWLGGSS-------EEQIAMY 475

  Fly   783 LCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSV-MVKKGDTALLQCAVSGD-------------- 832
            .....:||     ||:.|::.....:.....|: .:|:...|:   ..|||              
Human   476 NALVQDGI-----KVVLLELEKIQDYEKMPESIKFIKQKHGAI---RWSGDFTQGPQSAKTRFWK 532

  Fly   833 -----KPINIVWMRSGKNTLNPSTNYKISVKQEA 861
                 .|:......|....|:|:|..|:  ::||
Human   533 NVRYHMPVQRRSPSSKHQLLSPATKEKL--QREA 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845 5/9 (56%)
I-set 238..327 CDD:254352 14/88 (16%)
Ig 247..327 CDD:299845 14/79 (18%)
I-set 332..418 CDD:254352 24/102 (24%)
IGc2 344..407 CDD:197706 19/79 (24%)
IG_like 432..517 CDD:214653 10/84 (12%)
IGc2 436..507 CDD:197706 9/70 (13%)
I-set 521..610 CDD:254352 20/111 (18%)
IGc2 533..597 CDD:197706 17/86 (20%)
Ig 630..699 CDD:143165 19/74 (26%)
IG_like 714..802 CDD:214653 16/87 (18%)
Ig 725..802 CDD:299845 13/76 (17%)
Ig 823..894 CDD:143165 12/58 (21%)
FN3 906..1006 CDD:238020
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
IL1R1NP_000868.1 Ig1_IL1R_like 24..113 CDD:319308 24/127 (19%)
Ig2_IL1R_like 128..219 CDD:319309 26/170 (15%)
IG 234..328 CDD:214652 19/96 (20%)
TIR 384..540 CDD:214587 36/197 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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