DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and LRIT3

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	625	Identity:	131/625 - (20%)
Similarity:	216/625 - (34%)	Gaps:	179/625 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCV 260
            |...:...|:...|..|.      :...||.|.:::.:..|..:|:.     ::|.:....|:
Human    30 HGRNDGSGSRLVLCNDMD------MNELPTNLPVDTVKLRIEKTVIR-----RISAEAFYYLV-- 81

  Fly   261 AQGCPSPEYSWFTHNGAGPLPV-------------LSG------PRVRLLG-PIL--------AI 297
                 ..:|.|.|:|....:..             |.|      |...||. |:|        .|
Human    82 -----ELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKI 141

  Fly   298 EAVTGEDSGVYKCTAGNVGGEASAELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSP-- 360
            .:|..|.....|    |:.....:..|||...|..:|...:::|...|         ..:.||
Human   142 TSVPNEALRYLK----NLAYLDLSSNRLTTLPPDFLESWTHLVSTPSG---------VLDLSPSR 193

  Fly   361 --VGMQNILWYKD---GRQLPSSGRVEDTLVV--PRVSRENRGMYQCVVRRPE---GDTFQATAE 415
              :|:|:..|:.|   .:.:..|..|:..:|:  |        :..|  ..||   |..|| .||
Human   194 IILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDP--------LMTC--SEPERLTGILFQ-RAE 247

  Fly   416 LQLGDAPPVLLYSF-IEQTLQPGPAVSLKCSAAGNPTPQISWT-LDGFPLPSNGRFMIGQYITVH 478
            |:....|.|:..:. |...|  |..|.|:|.|.|.|||||:|| .|..|:    .:.:.|.....
Human   248 LEHCLKPSVMTSATKIMSAL--GSNVLLRCDATGFPTPQITWTRSDSSPV----NYTVIQESPEE 306

  Fly   479 GDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPV 543
            |...|.::::.:..:|.|:|.|.|:|.||..:....:.:.|:....:.|..:..:|:
Human   307 GVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGD-------- 363

  Fly   544 AGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTV 608
              :|    .|:             |||....:.|.    |.:..| .|:   ...|...|...:.
Human   364 --HP----EWD-------------VQPGSGRSTSV----SSASSY-LWS---SSFSPTSSFSAST 401

  Fly   609 IVPP-----KLSPFQTNIL----------------------QLNMGDRASLTCSVVKGDLPLTIN 646
            :.||     .||||.::.:                      ||:.|.:.:|..:.....||
Human   402 LSPPSTASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLP---- 462

  Fly   647 WRKDGRPIDPTQHMSVKQVDQ---YNSILVIENL--------GSDHTGNYSCVVRNSAAEVENSQ 700
                  |...::...:..:||   ..:...||||        ....|.|......|||..|..|:
Human   463 ------PASTSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSK 521

  Fly   701 -----ALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVP 735
                 .||:|.........:|......:::...| .:|||
Human   522 YGGKDLLLLNADSSKNQVTIDGLEPGGQYMACVC-PKGVP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845	1/6 (17%)
		I-set	238..327	CDD:254352	21/116 (18%)
		Ig	247..327	CDD:299845	20/107 (19%)
		I-set	332..418	CDD:254352	22/97 (23%)
		IGc2	344..407	CDD:197706	14/74 (19%)
		IG_like	432..517	CDD:214653	27/85 (32%)
		IGc2	436..507	CDD:197706	24/71 (34%)
		I-set	521..610	CDD:254352	13/88 (15%)
		IGc2	533..597	CDD:197706	10/63 (16%)
		Ig	630..699	CDD:143165	16/79 (20%)
		IG_like	714..802	CDD:214653	5/22 (23%)
		Ig	725..802	CDD:299845	4/11 (36%)
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
LRIT3	NP_940908.3	LRR 1	56..79		3/27 (11%)
		leucine-rich repeat	59..82	CDD:275378	4/34 (12%)
		LRR_8	61..117	CDD:290566	10/67 (15%)
		LRR 2	80..103		5/29 (17%)
		leucine-rich repeat	83..106	CDD:275378	4/22 (18%)
		LRR 3	104..128		5/23 (22%)
		LRR_8	105..165	CDD:290566	12/63 (19%)
		LRR_4	105..146	CDD:289563	9/40 (23%)
		leucine-rich repeat	107..130	CDD:275378	5/22 (23%)
		LRR 4	129..151		5/21 (24%)
		LRR_4	131..170	CDD:289563	9/42 (21%)
		leucine-rich repeat	131..154	CDD:275378	5/26 (19%)
		LRR 5	152..175		6/26 (23%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		Ig	267..345	CDD:299845	27/83 (33%)
		IG_like	267..345	CDD:214653	27/83 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		7/50 (14%)
		FN3	486..550	CDD:214495	15/63 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900