DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and DIP-eta

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	344	Identity:	85/344 - (24%)
Similarity:	137/344 - (39%)	Gaps:	51/344 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 NKQGHSARRSGEVTVIVPPKLSPFQTNILQLN--MGDRASLTCSVVKGDLPLTINWRK------- 649
            ::|.:..|......|||.||   |.:.|:.:.  :|..|.||| ||:...|..:.|.:
  Fly    25 SQQCYPQRVEVPAEVIVDPK---FSSPIVNMTAPVGRDAFLTC-VVQDLGPYKVAWLRVDTQTIL 85

  Fly   650 --DGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIV 712
              ....|...|.:.:...:.....:.|:::.....|.|.|.:.....:.:... |.|.|||..:.
  Fly    86 TIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGY-LDVVVPPDILD 149

  Fly   713 EP--VDANVERNRHIMLHCQAQGVPTPSIVWKK--------ATGSKSGEYEEVRERPFTKLLGNG 767
            .|  .|..|....::.|.|.|.|.|.|:|.|::        |||      |||..      :...
  Fly   150 YPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATG------EEVMS------IEGT 202

  Fly   768 SLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQC-AVSG 831
            .|::.:|:....|.|||.|:||:...:.|.|.|.|:..|..:..::.:...:|....|.| :.:.
  Fly   203 DLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAY 267

  Fly   832 DKPINIVWMRSGKNTLNPSTNYKISVKQEATPDG---VSAELQIRTVDATDSGPYFCRASNLYGN 893
            .|.|| .|.|.....:.|...|..:|    |..|   .|..|.|..:...:.|.|.|.|.|..|:
  Fly   268 PKSIN-YWTRERGEIVPPGGKYSANV----TEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGD 327

  Fly   894 DQQLVQLQVQEPPLPPSVL 912
            ....::|.    .:||:.:
  Fly   328 TDGTIKLY----RIPPNAV 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	3/15 (20%)
		IGc2	533..597	CDD:197706	0/2 (0%)
		Ig	630..699	CDD:143165	14/77 (18%)
		IG_like	714..802	CDD:214653	29/97 (30%)
		Ig	725..802	CDD:299845	26/84 (31%)
		Ig	823..894	CDD:143165	21/74 (28%)
		FN3	906..1006	CDD:238020	2/7 (29%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	16/91 (18%)
		IG_like	51..137	CDD:214653	15/86 (17%)
		IG_like	153..237	CDD:214653	28/95 (29%)
		Ig	161..224	CDD:299845	21/74 (28%)
		IG_like	252..335	CDD:214653	22/87 (25%)
		Ig	258..333	CDD:143165	21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810