DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam2 and itgb4

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio


Alignment Length:1060 Identity:228/1060 - (21%)
Similarity:360/1060 - (33%) Gaps:370/1060 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 VAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQ------GHSAR 601
            ||..||:        |::.:|.|.:|      |.|.....         |::|:      |..:.
Zfish  1008 VANIPIK--------RQIIEDGRAQV------TYSTADLT---------AKDKKDYISVDGDLSY 1049

  Fly   602 RSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVD 666
            .:||...|||.||         |.:|::..|                           :..|||.
Zfish  1050 GAGETEKIVPVKL---------LELGEQDGL---------------------------LEDKQVK 1078

  Fly   667 QYNSILVIEN-LGSDHTGNYSCVVRNSAAEVENSQAL-------------LVNVPPRWIVEPVDA 717
            |:  ::.:.| ..|...|.|...|...|.:.|:|...             |..:|          
Zfish  1079 QF--VMDLTNPRQSAKLGRYPRTVITIADKPESSVMAFKKSTQTFSTTDSLYTIP---------- 1131

  Fly   718 NVER--NRHIMLHCQAQGVPTPSIV-WKKATGSK----------SGEYEE-----VRERPFTKLL 764
             |||  ||.           ||:.| |:....|:          .||.|:     .|..|...:.
Zfish  1132 -VERTGNRE-----------TPATVHWRTNKASRFDISSPLKFAPGEAEKNILINPRTHPSPIIP 1184

  Fly   765 GNGSLLLQHVKEDREGFYLCQANNGI-------------GTGIGKVIQLKVNSSPYFSSTSRSVM 816
            ...:|.|           |..:||.|             |.|.||  ........|.:.|:.|..
Zfish  1185 EKFNLEL-----------LDPSNNAIIGKRKTTEVIVTDGRGDGK--NQDFQKMEYVTQTATSPG 1236

  Fly   817 VKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTN---YKISVKQEATPDGVSAELQIRTVDA- 877
            .:....|.::...:|.|.|.:.|        .||.|   ||:.......|:..:..:.::|..| 
Zfish  1237 GRLYSPANIKAVATGPKNIRLNW--------KPSQNANGYKVKYWIYGDPEDKAKFMDVKTPQAE 1293

  Fly   878 -TDSGPY------FCRASNL-YGNDQQLVQLQ-VQEPPLPPSVLEAAMISSRSVNIKWQPKTLGT 933
             |:..||      .|..:.| .||...::|.| :::.|..|..|...:||.....:.|.......
Zfish  1294 LTNLDPYCDYEMRVCGYNALGDGNYSDIIQCQTLEDIPGEPGRLAFNVISPTVTQVSWAEPAEAN 1358

  Fly   934 GDVTKYIVEFREADHSL----PPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAG 994
            |.:|.|.|.:...:...    ||       :::.:.:|.....:||||:|:..|.::|.|....|
Zfish  1359 GIITGYEVIYMPINEDKKPTGPP-------KKVMIDNPKKRMLLIENLQPSQTYCYKVRASNKVG 1416

  Fly   995 RSAPSQELIVR--TEPQRPAGPPL-------------SLSARPLSSTELLISWVAPLPELRH--- 1041
             ..|.:|..:.  ::|.||...|:             ...:..:.|.|:|.|   |...||.   
Zfish  1417 -WGPYREATINLASQPTRPMSIPIIPDIPIVDAEAGEEYDSYLMYSNEVLRS---PTSSLRPSVT 1477

  Fly  1042 --GDIQGYN------------VGYKLS---SSGNTAYNF--------------TSVSGDG----- 1070
              .|.|..|            .|..||   ||.:|.|:.              |.:||.|     
Zfish  1478 DLSDDQFVNGKWEQNFLFPGGGGGSLSRNISSSSTTYSHSTPRTNVTNNSSTTTYISGKGGSTTH 1542

  Fly  1071 -----DGG--NGELLLSGLAKFARYT---------------------VVVQAFNQVGPGPLSEPT 1107
                 |||  ..:::|...::...||                     :.|.:|:|......|..:
Zfish  1543 RYDVRDGGLLKEDVILRKRSENRHYTEGDGVRDSIVMGNLSGGLLDNLGVSSFSQTTSTSYSLSS 1607

  Fly  1108 AAQTM-EDV-----------------PSRP--PEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGY 1152
            .|:|. ||:                 |..|  |..:..:||...:|:||||.|   |....:.||
Zfish  1608 RARTQSEDINDALLNLDSVLQESRFTPGVPATPSRLVFSALGHTALKVSWQEP---HCESDVLGY 1669

  Fly  1153 KLIFEPII-DDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMG-----DGVVS---- 1207
            .::::.|. .|::    .:|.......::::..|....:|..:|.|.:|.|     :||::    
Zfish  1670 CVLYQLINGGDVK----RIEVNNPAQNSVLVQDLLPNQSYIFKVKAQSREGWGPEREGVITIESN 1730

  Fly  1208 ----KPL-------FCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNG 1261
                .||       |..|   .|.||..:...:....:|.:||..|.:|||.|..|.:....::|
Zfish  1731 VDPKSPLSPVPGSPFTLS---TPSAPGPLIFTALRPDTLQLSWEKPRKPNGDILGYVVTCEQLHG 1792

  Fly  1262 REEL------NNEKRSLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPAR 1320
            ..:|      .|...||       ....|..:|.|:|.|.|.|..|.|              |.|
Zfish  1793 GGDLRSFQVNGNAATSL-------TVSDLKENMPYKFKVQAQTTQGFG--------------PER 1836

  Fly  1321 --IISF----GGPVVRPWRSTVTLPCTAVGKPKREWFKSDVALRQGGLHNSQLLDS-------GD 1372
              ||:.    ||.:.:....:||         |||.|.....:    .|.|..:.|       |.
Zfish  1837 EGIITIESQDGGSMSQYSSQSVT---------KREVFNLPTEI----THTSHTMFSEPFVSSDGM 1888

  Fly  1373 LIISSLQLAD-GGNYSCQVD 1391
            :::||.|:.: ||:.:.||:
Zfish  1889 MMMSSRQITESGGSMTRQVE 1908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352
Ig 247..327 CDD:299845
I-set 332..418 CDD:254352
IGc2 344..407 CDD:197706
IG_like 432..517 CDD:214653
IGc2 436..507 CDD:197706
I-set 521..610 CDD:254352 15/72 (21%)
IGc2 533..597 CDD:197706 12/59 (20%)
Ig 630..699 CDD:143165 12/69 (17%)
IG_like 714..802 CDD:214653 25/118 (21%)
Ig 725..802 CDD:299845 20/105 (19%)
Ig 823..894 CDD:143165 19/82 (23%)
FN3 906..1006 CDD:238020 24/105 (23%)
FN3 1013..1111 CDD:238020 33/177 (19%)
FN3 1119..1209 CDD:238020 24/105 (23%)
FN3 1219..1313 CDD:238020 26/99 (26%)
Ig 1336..1402 CDD:143165 17/64 (27%)
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776
EGF_2 <468..490 CDD:285248
EGF_2 545..573 CDD:285248
Integrin_B_tail 625..709 CDD:285239
Calx-beta 991..1064 CDD:295344 20/87 (23%)
FN3 1242..1326 CDD:238020 21/91 (23%)
FN3 1331..1420 CDD:238020 22/96 (23%)
fn3 1640..1720 CDD:278470 21/86 (24%)
fn3 1751..1835 CDD:278470 25/104 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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