DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and Il1rapl1

DIOPT Version :9

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_808796.1 Gene:Il1rapl1 / 317553 RGDID:727891 Length:696 Species:Rattus norvegicus


Alignment Length:550 Identity:125/550 - (22%)
Similarity:194/550 - (35%) Gaps:163/550 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 QVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPL-- 280
            ||:|..|.|::.....|.|       ..:..::|..|..|:            |:..:|.|..  
  Rat    42 QVLVGEPVRIKCALFYGYI-------RTNYTLAQSAGLSLM------------WYKSSGPGDFEE 87

  Fly   281 PV-LSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRLTVA---TPI---------- 331
            |: ..|.|:......:.......:|||:|.|...|........:.|||.   |.:          
  Rat    88 PIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFE 152

  Fly   332 QVEISPNVLSVHMGGTAEFRCL-VTSNGSPVGMQNILWYKDGRQ---LPSSGRVEDTLVVPRVSR 392
            :.|:|.         :.|..|. :.....|.....|||||:.|.   .||.....|||::..|..
  Rat   153 KAELSK---------SKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIKEVKE 208

  Fly   393 ENRGMYQC-------VVRRPEGDTFQATAELQLGDAPPVLLYSF-----IEQTLQPGPAVSLKCS 445
            ::.|.|.|       ||||    |.:.|....|.|.||.|||..     |::| |.|.:.:|.|.
  Rat   209 DDIGNYTCELKYGGFVVRR----TTELTVTAPLTDKPPKLLYPMESKLTIQET-QLGGSANLTCR 268

  Fly   446 A----AGNPTPQISW--------TLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVM--VEDG- 495
            |    :|:.:|.|.|        .||...:..:...::.:::   |:  ..|:||.::  ||:| 
  Rat   269 AFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHL---GE--QEVSISLIVDSVEEGD 328

  Fly   496 -GEYACIAENRAGRVQHAARLNIYGLPY-IRLIPKVTAVSGETLNLKCPVA---GYPIEEIHWER 555
             |.|:|..||..||...:..|:...|.| :.|...:.|:   .|.|.|.|.   .|.||.:.:.|
  Rat   329 LGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAI---LLLLVCSVTIYKCYKIEIMLFYR 390

  Fly   556 ---GGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPF 617
               |..||..|                  |.|...|..:.                    |:.|.
  Rat   391 NHFGAEELDGD------------------NKDYDAYLSYT--------------------KVDPD 417

  Fly   618 QTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHT 682
            |.|   ...|:.......::...|               .:|...|        |.|.:.....|
  Rat   418 QWN---QETGEEERFALEILPDML---------------EKHYGYK--------LFIPDRDLIPT 456

  Fly   683 GNYSCVVRNSAAEVENSQALLVNVPPRWIV 712
            |.|   :.:.|..|:.|:.|::.:.|.::|
  Rat   457 GTY---IEDVARCVDQSKRLIIVMTPNYVV 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 51..127 CDD:299845
Ig 138..>203 CDD:299845
I-set 238..327 CDD:254352 16/91 (18%)
Ig 247..327 CDD:299845 16/82 (20%)
I-set 332..418 CDD:254352 26/96 (27%)
IGc2 344..407 CDD:197706 22/73 (30%)
IG_like 432..517 CDD:214653 27/100 (27%)
IGc2 436..507 CDD:197706 22/86 (26%)
I-set 521..610 CDD:254352 18/95 (19%)
IGc2 533..597 CDD:197706 15/69 (22%)
Ig 630..699 CDD:143165 10/68 (15%)
IG_like 714..802 CDD:214653
Ig 725..802 CDD:299845
Ig 823..894 CDD:143165
FN3 906..1006 CDD:238020
FN3 1013..1111 CDD:238020
FN3 1119..1209 CDD:238020
FN3 1219..1313 CDD:238020
Ig 1336..1402 CDD:143165
FN3 1409..1498 CDD:238020
FN3 1515..1588 CDD:238020
Il1rapl1NP_808796.1 PHA02785 9..334 CDD:165149 81/329 (25%)
Ig1_IL1RAPL-1_like 32..135 CDD:143304 23/111 (21%)
Ig 148..234 CDD:299845 26/98 (27%)
IGc2 260..341 CDD:197706 22/85 (26%)
TIR 405..559 CDD:279864 19/127 (15%)
Interaction with NCS1. /evidence=ECO:0000250 549..644
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 659..680
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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