DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	2151	Identity:	661/2151 - (30%)
Similarity:	1022/2151 - (47%)	Gaps:	211/2151 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWISSRFFVILLLLNLDNTCSEPFEAHLRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDW 65
            ||:.:   .:|||.:|.....|.....|.   ||.:....|.||:|.|..:.|.|:|||...:.|
  Rat    59 MWLVT---FLLLLDSLHKARPEDVGTSLY---FVNDSLQHVTFSSSVGVVVPCPAAGSPSAALRW 117

  Fly    66 VHADGSAVTEIHGVRRVLRNGTLVLMPFAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVA 130
            ..|.|..:.::..:|.|..||||.|.||:.:|::..:|:..|.|.|.|:.|:|.|.:::::||..
  Rat   118 YLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRIKAVFR 182

  Fly   131 QAYKVDVEVLSAARGCTAILRCVVPTFVKELVRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLI 195
            :.|.|.||...:.||..|:.:|::|:.|:|.|.||||..:..     |:..:.:|.:...|.|.|
  Rat   183 EPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTV-----SITPENRFFITSHGGLYI 242

  Fly   196 HNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCV 260
            .::|:.|...::||.:.|:.:.:...|:..||.:......| |::::.....:|.......|.|.
  Rat   243 SDVQKEDALSTYRCITQHKYSGETRQSNGARLSVTDPAESI-PTILDGFHSQEVWTGHAVELPCA 306

  Fly   261 AQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRL 325
            |.|.|.|...|.  ....|||..|....|:.|  |.|..:..||||.|.|...|..|.|.|...|
  Rat   307 ASGYPIPAIRWL--KDGRPLPADSRWAKRITG--LTISDLRTEDSGTYICEVTNTFGSAEANGVL 367

  Fly   326 TVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKD------GRQLPSSGRVEDT 384
            ||..|:.|.::|..|...:|.|....|.:|  |||  ...|.||::      |..:...|...:|
  Rat   368 TVIDPLHVTLTPKKLKTGIGSTVILSCALT--GSP--EFTIRWYRNTELVLPGEAISIRGLSNET 428

  Fly   385 LVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGN 449
            |::....:.:.|.|||...| :..|.|..|.:.|.|..|.::.||.|:.:.||...||.|:|.|.
  Rat   429 LLISSAQKSHSGAYQCFATR-KAQTAQDFAIIVLEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGA 492

  Fly   450 PTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAAR 514
            |.|.::|.||..|:..:|.....||....|..|||:|::...:.|||.|.|.|.|..|..::.||
  Rat   493 PPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNSVGSAEYQAR 557

  Fly   515 LNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPV 579
            :|:.|.|.||.:..:|||:|....:.|.|.|||...|.|.:....|||:.||.|..:|:|.::.|
  Rat   558 INVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDV 622

  Fly   580 QKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLT 644
            ||..|.|.|.|....:...|..:|..|.|.|||.:.||:  ....::|....:.|.|..||:|:.
  Rat   623 QKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE--FPPASIGQLLYIPCVVSSGDMPIR 685

  Fly   645 INWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPR 709
            |.|||||:.|.....::::. .::.|.|.|.::...|.|||:|:..|:||.|...:.|:|.||||
  Rat   686 ITWRKDGQVIISGSGVTIES-KEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPR 749

  Fly   710 WIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFT---KLLGNGSLLL 771
            ::|:|.:.:....:..:|:|...|.|.|.::||.|.|  ||..::....|.|   ::|.|.|||:
  Rat   750 FVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKG--SGNPQQYHPVPLTGRIQILPNSSLLI 812

  Fly   772 QHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPIN 836
            :||.|:..|:|||||:||:||.|.|.:.|.|......:|...:.:..||....|.|...|::||.
  Rat   813 RHVLEEDIGYYLCQASNGVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPII 877

  Fly   837 IVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQ 901
            |.| ..|...::|....:.::..:...|.|.:.|:::..|..||..:.|.|.|.||.|:.|:||.
  Rat   878 IRW-EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLT 941

  Fly   902 VQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQW---QQIE 963
            |||||.||. ||...:.:||:|::|..:..|...:|.:.:|::...         |.|   |...
  Rat   942 VQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKS---------DSWDFKQSTR 996

  Fly   964 VKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTEL 1028
            ...|....|.|.:|.||:.|:.|:.:....|||.||:||.:.||...|.|||:.::.:|::|..:
  Rat   997 NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSI 1061

  Fly  1029 LISWVAPLPELRHGDIQGYNVGYKLSSSG-NTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVV 1092
            .::|.||..||::|.|:||.:||:.:|.| |..|:...:...||  :....|..|.|||:|.|||
  Rat  1062 QVTWKAPKKELQNGIIRGYQIGYRENSPGSNGQYSIVEMKATGD--SEVYTLDNLKKFAQYGVVV 1124

  Fly  1093 QAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLIFE 1157
            ||||:.|.||.|....|.|:|||||:|||:||..:::|....:||..||....||:|:||::||.
  Rat  1125 QAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW 1189

  Fly  1158 PIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAP 1222
            .:.  :.....|:::..||...:.|.|:.|:||||:||||:|:.||||.|..|:..::||||..|
  Rat  1190 SLY--VDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPP 1252

  Fly  1223 ADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPH 1287
            |.||.|.||:.|:.:|||||.:|||||.||:::.......:...:|..:.| :|.:|....|:..
  Rat  1253 AGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSP-EQLFYRIAHLNRG 1316

  Fly  1288 MEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKR--EW 1350
            .:|..||.|.|..|.|.||...:.....:.||:||||||.|..||...|.|||.:||.|..  :|
  Rat  1317 QQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWLKDVRLPCNSVGDPAPAVKW 1381

  Fly  1351 FK-SDVALRQGGLHNSQLL-DSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPV 1413
            .| |:.:.....|...:|: .:|.|::.:::..|.|.|:|...|..|.|.:...|:|||||..|.
  Rat  1382 TKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR 1446

  Fly  1414 LYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQ---LSRHASSHELKGLMCGSTY 1475
            |.|:..::|||.:.|..|..|.:.|.|:.|.|  :..|::|.:   :|....|.:|..|.||:.|
  Rat  1447 LTVSKTSASSITLTWIPGDNGGSSIRGFVLQY--SVDNSEEWKDVFISSSERSFKLDSLKCGTWY 1509

  Fly  1476 QIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAP-NSTSLLVRLHSWPDNGCPLLYFVLQ 1539
            ::.|:|:|.||:...|.|:..:|.|:.|.......|... |||...:.|..|.:.|||:...||:
  Rat  1510 KVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLE 1574

  Fly  1540 YRAVTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDPP 1604
            ||     |...|............:.:..|:.:|.|:|||.|.|.||.......|.||..||...
  Rat  1575 YR-----PKGTWAWQGVRANSSTEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTI 1634

  Fly  1605 PPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYR-----HMLKNAPPLAEQSQI 1664
            ||....:|.......:|   .:..|.|.|..|:  .::.::...|     ..|::|..|||. .|
  Rat  1635 PPIKSAQGEGDDVKKLF---TIGCPVILATLGV--ALLFVVRKKRKEKRLKRLRDAKSLAEM-LI 1693

  Fly  1665 QKESLENRANSEAA----QRERYYATIHKVSMQNNDK------------IPETSEDISPYATFQL 1713
            .|   .||:.....    |..|.:..|.:|.:...||            ||.|..:.|.....|.
  Rat  1694 SK---NNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKATIPVTDAEFSQAVNPQS 1755

  Fly  1714 SEAGGNMSQPHHGGPANTLLHSF--MYHERALAEGCSSPPPAASKN-RRRHSRKTEPESE----- 1770
            ...|.::   ||  ||  |:.|.  :.....:..|.:   |.:.|| :..||.:....|:
  Rat  1756 FCTGVSL---HH--PA--LIQSTGPLIDMSDIRPGTN---PVSRKNVKSAHSTRNRYSSQWTLTK 1810

  Fly  1771 -ESESDQDQLTS-----------------SRTESSNQHEGKIKHSIIYHGAQSSTSSDLSPMSEQ 1817
             ::.:....|||                 |.:.|.:|...|.::|::...:.|||..:|:...|.
  Rat  1811 CQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYEH 1875

  Fly  1818 KSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTATNTTATPSTSSNSNKILSP-- 1880
            ..|    ..:..|.:::. |.......:|::|...|  |.|..:..:.:|||.........||
  Rat  1876 AKL----EEQLQHAKFEI-TECFISDSSSDQMTTGT--NENADSMTSMSTPSEPGICRFTASPPK 1933

  Fly  1881 -----RGGNLKSISSTFKSQDSIQCHIPTLVKSPSISTQQQ----------KQFHKQQLQNSSTN 1930
                 ||.|: ::....::..|..|::|...||.:...:..          ::...:.|..:...
  Rat  1934 PQDADRGKNV-AVPIPHRANKSDYCNLPLYTKSEAFFRKADGREPCPVVPPREASMRNLTRAYHT 1997

  Fly  1931 NSQHSSSNPNSSSLKQQQPLLITPKLHQLEANGQELLGLDGIGNSPLVACMPPSSQFRPIPHKSI 1995
            .::|.:.:|.|..|....|                     |...:...|.:|..:...|.|....
  Rat  1998 QARHLTLDPASKPLGLPHP---------------------GATAATATATLPQRTLAMPAPPAGT 2041

  Fly  1996 MPAHEPPHHHNHSQQSHPHQQQQQQQHPGTLLNPSTAMLSSKFFTAPTLPKXDTANGGSEY--VG 2058
            .|....|   ..|:.|.|               ||         .||..|..:....|..:  :|
  Rat  2042 APPAPGP---TPSEPSAP---------------PS---------AAPPAPSTEPPRAGGPHTKMG 2079

  Fly  2059 GAMEAM 2064
            |:.:::
  Rat  2080 GSRDSL 2085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	26/75 (35%)
		Ig	138..>203	CDD:299845	19/64 (30%)
		I-set	238..327	CDD:254352	28/88 (32%)
		Ig	247..327	CDD:299845	27/79 (34%)
		I-set	332..418	CDD:254352	25/91 (27%)
		IGc2	344..407	CDD:197706	19/68 (28%)
		IG_like	432..517	CDD:214653	31/84 (37%)
		IGc2	436..507	CDD:197706	28/70 (40%)
		I-set	521..610	CDD:254352	33/88 (38%)
		IGc2	533..597	CDD:197706	23/63 (37%)
		Ig	630..699	CDD:143165	24/68 (35%)
		IG_like	714..802	CDD:214653	35/90 (39%)
		Ig	725..802	CDD:299845	34/79 (43%)
		Ig	823..894	CDD:143165	20/70 (29%)
		FN3	906..1006	CDD:238020	30/102 (29%)
		FN3	1013..1111	CDD:238020	40/98 (41%)
		FN3	1119..1209	CDD:238020	37/89 (42%)
		FN3	1219..1313	CDD:238020	35/93 (38%)
		Ig	1336..1402	CDD:143165	21/69 (30%)
		FN3	1409..1498	CDD:238020	30/91 (33%)
		FN3	1515..1588	CDD:238020	24/72 (33%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652	25/71 (35%)
		IGc2	101..168	CDD:197706	23/66 (35%)
		Ig	183..276	CDD:299845	29/97 (30%)
		IG_like	195..276	CDD:214653	25/85 (29%)
		I-set	291..369	CDD:254352	27/81 (33%)
		IGc2	298..359	CDD:197706	22/64 (34%)
		IGc2	386..447	CDD:197706	18/64 (28%)
		I-set	466..560	CDD:254352	35/93 (38%)
		Ig	466..556	CDD:299845	33/89 (37%)
		IGc2	577..635	CDD:197706	23/57 (40%)
		IG_like	665..744	CDD:214653	26/79 (33%)
		Ig	673..739	CDD:143165	24/66 (36%)
		I-set	748..843	CDD:254352	38/96 (40%)
		Ig7_DSCAM	765..843	CDD:143211	34/79 (43%)
		I-set	849..942	CDD:254352	27/93 (29%)
		Ig	861..949	CDD:299845	30/88 (34%)
		FN3	945..1039	CDD:238020	31/103 (30%)
		FN3	1046..1143	CDD:238020	40/98 (41%)
		fn3	1151..1237	CDD:278470	36/87 (41%)
		FN3	1249..1340	CDD:238020	35/91 (38%)
		IGc2	1364..1428	CDD:197706	19/63 (30%)
		FN3	1442..1532	CDD:238020	30/91 (33%)
		FN3	1546..1618	CDD:238020	24/76 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4784
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	968	1.000	Inparanoid score	I306
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9015
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840