DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	1638	Identity:	345/1638 - (21%)
Similarity:	574/1638 - (35%)	Gaps:	472/1638 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 PNVLSVHMGGTAEFRC----LVTSNGSPVGMQNILWYKDGRQLP---------------SSGRV- 381
            |..::...|.....||    .||....|..::   |:|.|..:|               .:||.
  Rat    30 PEFVTARAGEGVVLRCDVIHPVTGQPPPYVVE---WFKFGVPIPIFIKFGYYPPHVDPEYAGRAS 91

  Fly   382 ---EDTLVVPRVSRENRGMYQCVVRR--PEGDTFQATAELQLG-DAPPVLLYS---FIEQTLQPG 437
               :.:|.:.:|..|::|.|:|.|..  .:.|||...:.:.|. :|||....:   :||  .:.|
  Rat    92 LHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIE--AKEG 154

  Fly   438 PAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIA 502
            .::::.|:|.|||.|.::|..:|..|.::|::.:..         ..:.::.|..||.|.|.|.|
  Rat   155 GSITMTCTAFGNPKPIVTWLKEGTLLSASGKYQVSD---------GSLTVTSVSREDRGAYTCRA 210

  Fly   503 ENRAGRVQHAARLNIYGLPYIRLIPK-VTAVSGETLNLKCPVAGYP---IEEIHWERGGRELPDD 563
            .:..|...|...|.:.|.|:|...|: :|....:...|.|....||   ....:|:.......:|
  Rat   211 YSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND 275

  Fly   564 IRQRVQ--PDGSLTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPK---LSPFQTNILQ 623
            ::.||:  .||:|.|..| |..|:|.|||...|..|.|...|..:||..|.:   :.|    ::.
  Rat   276 LKLRVRILIDGTLIIFRV-KPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP----VIY 335

  Fly   624 LNMGDRASLTCSVVKGDLPLT-INWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSC 687
            :.:|....:.|. |..:.|.| :.|.|||||:...:::....::  :..:.||....:..|.|:|
  Rat   336 VPVGIHGYIRCP-VDAEPPATVVKWNKDGRPLQVEKNLGWTLME--DGSIRIEEATEEALGTYTC 397

  Fly   688 VVRNSAAEVENS--QALLVNVPPRWIVEP-VDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKS 749
            |..|:...:..|  ..|::..||.:.|.| .:...|..|.:::.|.|.|.|.|.|.|:| .|..|
  Rat   398 VPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRK-VGKPS 461

  Fly   750 GEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKV-NSSP------- 806
                    |.....|.:|||..:.:.::..|.:.|.|.| :.|.|.....|.| .:||
  Rat   462 --------RSKHNALPSGSLQFRALSKEDHGEWECVATN-VVTSITASTHLTVIGTSPHAPGSVR 517

  Fly   807 -YFSSTSRSVMVKKGDTA------------LLQCAVSG-------DKPINIVWMRSGKNTLNPST 851
             :.|.|:.:|..:.|...            |::.|..|       ..|:...|:.  .::|.|.|
  Rat   518 VHVSMTTANVSWEPGYDGGYEQTFSVWYGPLMKRAQFGPHDWLSLSVPLGPSWLL--VDSLEPET 580

  Fly   852 NYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEP-PL----PPSV 911
            .|:.||..: ...|.||..::.||:.                    :...|..| ||    ||..
  Rat   581 AYQFSVLAQ-NRLGTSAFSEVVTVNT--------------------LAFPVTTPEPLVLVTPPRC 624

  Fly   912 LEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDP---PHFNAM 973
            |.|.. :.:.|.:.|.|....:..:.:||:|||..          ::|:.::...|   ..|.|
  Rat   625 LTANR-TQQGVLLSWLPPANHSFPIDRYIMEFRVG----------ERWEMLDDAIPGTDGEFFA- 677

  Fly   974 IENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPE 1038
             ::|...|.|.|||:        |..|:||  :||...||         :|||::.     |.|:
  Rat   678 -KDLSQDTWYEFRVL--------AVMQDLI--SEPSNIAG---------VSSTDIF-----PQPD 717

  Fly  1039 LRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVG---- 1099
            |.                              |.|....:|:|:.....:......|:.:.
  Rat   718 LT------------------------------DDGLARPVLAGIVATICFLAAAILFSTLAACFV 752

  Fly  1100 ------------PGPLSEPTAAQTMEDVPSR---PPEDVRCAALSSQSLQVSWQP------PPIY 1143
                        ..|||.....:::|...|.   .||.:|.....|:|.....||      .|..
  Rat   753 NKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTR 817

  Fly  1144 HTNGLLQGYKLIFEPIID-DIQPSKDEVESRKTTALTMVLTGL-RKYTNYSIQVLAHTRMGDGVV 1206
            ...  |..||.....|.. ....:|.|.|:..||.:.::..|. .::      |:..:.|...|.
  Rat   818 EKE--LSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISRGPDGRF------VMGPSEMEPSVK 874

  Fly  1207 SK--------------PLFCHSEED-----VPEAPADIK---VVSSSSQSLYI---SWLPPNEPN 1246
            .:              |.|..|:|:     ||.:.|.:|   ...||||..|:   ::.|..:|.
  Rat   875 GRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKPQLTPMSSSQDSYLPPPAYSPRFQPR 939

  Fly  1247 GVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGLHPHMEYQFWVTAST------------R 1299
            |:.....|     .||.:...:.|. |:.:.:       .|.:|..::::|:            .
  Rat   940 GLEGPSGL-----GGRLQATGQARP-PAPRPF-------QHGQYYGYLSSSSPGEVEPPPFYMPE 991

  Fly  1300 VGEGKSSRVSSQITTNRIPARIISFGGPVVRPWR----STVTLPCTAV---GKPKREWFKSDVAL 1357
            ||...||.:||.......|     ||.|.:....    |..|||.|..   |:....|.:.:...
  Rat   992 VGSPLSSVMSSPPLHTEGP-----FGHPTIPEENGENASNSTLPLTQTPTGGRSPEPWGRPEFPF 1051

  Fly  1358 RQGGLHNSQLLDSGDL----IISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPVLYVTS 1418
              |||....::....|    :..|||     ...| :..|:              |.|| |.|.:
  Rat  1052 --GGLETPAMMFPHQLHPCDVAESLQ-----PKPC-LPRGL--------------PPAP-LQVPA 1093

  Fly  1419 ATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCGSTYQIHLSAQN 1483
            |....:.:....|:.|.:|..|                                   .|......
  Rat  1094 AYPGMLSLEAPKGWVGKSPGRG-----------------------------------PIPAPPAT 1123

  Fly  1484 KVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPD------NGCPLLYFVLQYRA 1542
            |....|...::   :|||          |...|..:.:.:..:|:      :|.|..:.:
  Rat  1124 KWQERPMQPLV---SQGQ----------LRHTSQGMGIPVLPYPEPAEPGGHGGPSTFGL----- 1170

  Fly  1543 VTDDPDAEWVLVSNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDP---- 1603
                 |..|.......:|..| .....:|| |:|:.::...::.::|:..:    ::.|.|
  Rat  1171 -----DTRWYEPQPRPRPSPR-QARRAEPS-LHQVVLQPSRLSPLTQSPLS----SRTGSPELAA 1224

  Fly  1604 ---PPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHMLKNAPPLAEQSQIQ 1665
               |.|.::.:....:.|        |.|. ||||              ...|:.|     |...
  Rat  1225 RARPRPGLLQQAEMSEIT--------LQPP-AAVS--------------FSRKSTP-----SSTG 1261

  Fly  1666 KESLENRANSEAAQRERYYATI------------HKVSMQNNDKIPET-------SEDISPYATF 1711
            ..|..:|:.|.:.:....:.|:            ......|.|...:|       .|.:.|....
  Rat  1262 SPSQSSRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDNLDVFGQTPSPRRMGEEPLRPEPPT 1326

  Fly  1712 QLSEAG------GNMSQPHHGGPANTLLHSFMYHERALAEGCSSPPPAASKNRRRHSRKTEPESE 1770
            .|..:|      ||.:.|..       |.:..|..       ...|..:||.    |.|::..|:
  Rat  1327 TLPTSGILPPAPGNAAVPER-------LEALRYQR-------IKKPKKSSKG----SSKSKKRSD 1373

  Fly  1771 ESESDQDQLTSSR 1783
            .|.|...||.:|:
  Rat  1374 GSASQDQQLPNSQ 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	23/105 (22%)
		IGc2	344..407	CDD:197706	19/87 (22%)
		IG_like	432..517	CDD:214653	21/84 (25%)
		IGc2	436..507	CDD:197706	18/70 (26%)
		I-set	521..610	CDD:254352	29/94 (31%)
		IGc2	533..597	CDD:197706	20/68 (29%)
		Ig	630..699	CDD:143165	17/69 (25%)
		IG_like	714..802	CDD:214653	25/88 (28%)
		Ig	725..802	CDD:299845	22/76 (29%)
		Ig	823..894	CDD:143165	16/89 (18%)
		FN3	906..1006	CDD:238020	28/106 (26%)
		FN3	1013..1111	CDD:238020	15/113 (13%)
		FN3	1119..1209	CDD:238020	21/111 (19%)
		FN3	1219..1313	CDD:238020	25/111 (23%)
		Ig	1336..1402	CDD:143165	15/72 (21%)
		FN3	1409..1498	CDD:238020	13/88 (15%)
		FN3	1515..1588	CDD:238020	12/78 (15%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021	83/460 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044		32/143 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332		46/312 (15%)
		Ig	41..115	CDD:319273	17/76 (22%)
		I-set	139..225	CDD:369462	24/96 (25%)
		Ig	229..321	CDD:386229	27/92 (29%)
		Ig	<353..414	CDD:386229	16/62 (26%)
		Ig	438..502	CDD:319273	21/73 (29%)
		FN3	510..605	CDD:238020	21/97 (22%)
		FN3	621..703	CDD:238020	28/104 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821		13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810