DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam2 and Fas2

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	183/767 - (23%)
Similarity:	298/767 - (38%)	Gaps:	149/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 ELQLGDAPPVLLYSFIEQTLQP-GPAVSLKCSAAGNPT-PQISWTLD----------GFPLPSNG 467
            ||....:|.:.:|...|...:| |..:.|.|    .|| |:.|...|          ..|.| ||
  Fly    24 ELTRAQSPILEIYPKQEVQRKPVGKPLILTC----RPTVPEPSLVADLQWKDNRNNTILPKP-NG 83

  Fly   468 RFMIGQYI-TVHGDVISHVNISHVMVEDGGEYACIAENRAGRV-QHAARLNIY-GLPYIRLIPKV 529
            |.....|. |:.|:.:: :.|:.:.||.||:|.|.|......: :....:..| .:.:.......
  Fly    84 RNQPPMYTETLPGESLA-LMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQ 147

  Fly   530 TAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQR-----VQPDGSLTISPVQKNSDSGVYT 589
            ....|:...:.|.|...|...|.|.|.|    |.||..     ||.:| |.|..||: ||.|:||
  Fly   148 YPTLGQDYVVMCEVKADPNPTIDWLRNG----DPIRTTNDKYVVQTNG-LLIRNVQE-SDEGIYT 206

  Fly   590 CWAR-NKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRP 653
            |.|. .:.|....|:..|.|.:.|::....||:             ..|:|. |...|....|:|
  Fly   207 CRAAVIETGELLERTIRVEVFIQPEIISLPTNL-------------EAVEGK-PFAANCTARGKP 257

  Fly   654 I-------DPTQHMSVKQVDQY-----NSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNV 706
            :       |.|| ::|...|::     ..::.|.::..|..|.|:|:.:|.|..|:....|.|.|
  Fly   258 VPEISWIRDATQ-LNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLV 321

  Fly   707 PPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKK-------ATGSKSGEYEEVRERPFTKLL 764
            .|: |.|..:....|.:.|.:.|:|:|.|.|:|.:::       ..|.:..:...:.|..|.:..
  Fly   322 RPQ-IYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEER 385

  Fly   765 G--NGSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSR--SVMVKKGDTALL 825
            |  .|:|.:.:.:...:|.|.|.|.|. |....|...:.|..:|.||....  .|...:...|.|
  Fly   386 GESTGTLRISNAERSDDGLYQCIARNK-GADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANL 449

  Fly   826 QCAVSGDKPINIVWMRSGKNTLN-PSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASN 889
            .|...|.....|.|..:|:...: ..||.||      ...|..::|.:..|.......|.|.|:|
  Fly   450 SCLAMGIPNATIEWHWNGRKIKDLYDTNLKI------VGTGPRSDLIVHPVTRQYYSGYKCIATN 508

  Fly   890 LYGNDQQLVQLQVQEPPLPPSVLEA----AMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSL 950
            ::|..:.  .:|::|..:|..|.||    ...::.:.:|:.....||. .:..|.|:::||.:..
  Fly   509 IHGTAEH--DMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGL-PILAYSVQYKEALNPD 570

  Fly   951 PPALFVDQWQQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAG--------------RSAPSQE 1001
            ....:...|.    .|.|:   ::|.|:|.|.|:||..|....|              ||||.:.
  Fly   571 WSTAYNRSWS----PDSPY---IVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEP 628

  Fly  1002 LIVRTEPQRPAGPPLSLSARPLSSTELLISWVAPLPELRHGD-IQGYNVGY-----------KLS 1054
            ..:....|.....|:.:|  |.|. ...:.|..|..   :|: |..|.:.|           :|.
  Fly   629 KPLHNPVQHDKEEPVVVS--PYSD-HFELRWGVPAD---NGEPIDRYQIKYCPGVKISGTWTELE 687

  Fly  1055 SSGN-------TAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVG 1099
            :|.|       |::..|.:.|:                ..|.:.::|.|.:|
  Fly   688 NSCNTVEVMETTSFEMTQLVGN----------------TYYRIELKAHNAIG 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	2/2 (100%)
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653	25/98 (26%)
		IGc2	436..507	CDD:197706	25/83 (30%)
		I-set	521..610	CDD:254352	29/94 (31%)
		IGc2	533..597	CDD:197706	25/69 (36%)
		Ig	630..699	CDD:143165	19/80 (24%)
		IG_like	714..802	CDD:214653	21/96 (22%)
		Ig	725..802	CDD:299845	20/85 (24%)
		Ig	823..894	CDD:143165	19/71 (27%)
		FN3	906..1006	CDD:238020	27/117 (23%)
		FN3	1013..1111	CDD:238020	20/106 (19%)
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	26/99 (26%)
		IG_like	144..226	CDD:214653	28/87 (32%)
		IGc2	152..209	CDD:197706	24/62 (39%)
		I-set	230..319	CDD:254352	23/103 (22%)
		IGc2	243..309	CDD:197706	16/67 (24%)
		IG_like	330..424	CDD:214653	21/94 (22%)
		IGc2	339..412	CDD:197706	17/72 (24%)
		Ig	447..518	CDD:143165	19/78 (24%)
		fn3	534..611	CDD:278470	19/84 (23%)
		FN3	640..735	CDD:238020	20/106 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000